DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and Zfp458

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	XP_017170999.1	Gene:	Zfp458 / 238690	MGIID:	3040691	Length:	790	Species:	Mus musculus

Alignment Length:	568	Identity:	197/568 - (34%)
Similarity:	267/568 - (47%)	Gaps:	41/568 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   221 HVCDICGKMFQFRYQLIVHRRYHSERKPFMCQVCGQGFTTSQDLTRHGKIHIGGPMFTCIVCFNV 285
            :.|..|||.|:.:.....|||.|...|.:.|:.||:.|.....|:.|.:.|.|...:.|.:|...
Mouse   119 YTCKECGKGFEHKKVYQNHRRIHLRVKSYKCEECGKSFRFPSLLSAHKRNHTGQKPYNCEICSKA 183

  Fly   286 FANNTSLERHMKRHSTDKPFACTICQKTFARKEHLDNHFRSHTGETPFRCQYCAKTFTRKEHMVN 350
            |...:.|..|.:.|...||:......||......|..|...||||.|::|:...|.|.....:.|
Mouse   184 FHVPSLLSVHKRIHRVQKPYKSEDYGKTLHCPSLLSQHKIVHTGEKPYQCEDLGKAFRYPSRLSN 248

  Fly   351 HVRKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYTRKEHLANHMRSHTNET 415
            |.:.||||.||:|::|.|:|.......||...|||:.|::|:||||.:.....|:.|...||.|.
Mouse   249 HKKIHTGEKPHKCEVCGKAFDYPSRLSNHKRIHTGEKPYKCEVCGKAFHDPSKLSQHKIIHTGEK 313

  Fly   416 PFRCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRCSYCMK 480
            |::||:|||:|......:.|.:.||.|...:||.|.|.|.....|..|...||||.|::|..|.|
Mouse   314 PYKCEVCGKTFHYPSILSKHKIIHTKENLCKCDICGKAFHYPLLLSQHKIVHTGEKPYKCEDCGK 378

  Fly   481 TFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTGESPHKCTYCTKTFTRKEHLT 545
            .|.....|..|.:.||||.|:||..|.|||.....:..|:..||.|:|:||..|.|.|.....|:
Mouse   379 AFYYPSRLSRHKKIHTGEKPYKCEVCGKAFYYLSILSKHMIVHTEENPYKCEVCGKAFDYPSRLS 443

  Fly   546 NHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTFTRKEHLNNHMRQHSSD 610
            ||.:.||.|.||:|..|...|.....|..|..:|||:.|:||:.|.|.|.....|:.|.:.|:.|
Mouse   444 NHKKIHTEDKPHKCEVCGNAFCFSSSLRKHKIIHTGEKPYKCDICGKAFGSPSRLSKHNKIHTED 508

  Fly   611 NPHCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGKSFPLKGNLLFHQRSHT---------- 665
            .|:.|.||.|.|.....|:.| .|.|||::|:.||.|||:|.....|..|:|.||
Mouse   509 KPYKCEVCGKAFHFPSLLLVH-KRIHTGEKPYKCEVCGKAFYCLSTLSVHKRIHTGEYAYKCEVC 572

  Fly   666 --------------KGQEMERPFACEKCPKNFICKGHLVSHMRSHSGEKPHACTLCSKAFVERGN 716
                          :....|:|:.||.|.:.|.....|..|.|.|||||||.|.:|.|:|.....
Mouse   573 GKAFHCLSTLSVHKRIHTQEKPYKCEVCGQAFHASSKLSHHKRIHSGEKPHKCEICGKSFYYPSR 637

  Fly   717 LKRHM------KMNHPDA---MMPPPPVHPHPQIPAGVLTQVKQEVKP 755
            |.:|.      |..|..|   .:..|..|..|:       .:|...||
Mouse   638 LSKHKVIHTGEKPYHSQASGKTLDYPSRHSKPK-------TIKTGEKP 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	8/19 (42%)
		C2H2 Zn finger	251..271	CDD:275368	6/19 (32%)
		C2H2 Zn finger	279..299	CDD:275368	5/19 (26%)
		COG5048	300..723	CDD:227381	164/452 (36%)
		C2H2 Zn finger	307..327	CDD:275368	4/19 (21%)
		C2H2 Zn finger	335..355	CDD:275368	5/19 (26%)
		C2H2 Zn finger	363..383	CDD:275368	6/19 (32%)
		C2H2 Zn finger	391..411	CDD:275368	7/19 (37%)
		C2H2 Zn finger	419..439	CDD:275368	7/19 (37%)
		C2H2 Zn finger	447..467	CDD:275368	7/19 (37%)
		C2H2 Zn finger	475..495	CDD:275368	6/19 (32%)
		C2H2 Zn finger	503..523	CDD:275368	6/19 (32%)
		C2H2 Zn finger	531..551	CDD:275368	7/19 (37%)
		C2H2 Zn finger	559..579	CDD:275368	5/19 (26%)
		C2H2 Zn finger	587..607	CDD:275368	6/19 (32%)
		C2H2 Zn finger	615..636	CDD:275368	8/20 (40%)
		C2H2 Zn finger	644..664	CDD:275368	9/19 (47%)
		C2H2 Zn finger	676..696	CDD:275368	7/19 (37%)
		C2H2 Zn finger	704..722	CDD:275368	6/23 (26%)
Zfp458	XP_017170999.1	KRAB	43..101	CDD:214630
		transpos_ISL3	110..>157	CDD:411183	13/37 (35%)
		C2H2 Zn finger	121..141	CDD:275368	8/19 (42%)
		C2H2 Zn finger	149..169	CDD:275368	6/19 (32%)
		C2H2 Zn finger	177..197	CDD:275368	5/19 (26%)
		C2H2 Zn finger	209..225	CDD:275368	4/15 (27%)
		C2H2 Zn finger	233..253	CDD:275368	5/19 (26%)
		COG5048	257..727	CDD:227381	153/430 (36%)
		C2H2 Zn finger	261..281	CDD:275368	6/19 (32%)
		C2H2 Zn finger	289..309	CDD:275368	7/19 (37%)
		C2H2 Zn finger	317..337	CDD:275368	7/19 (37%)
		C2H2 Zn finger	345..365	CDD:275368	7/19 (37%)
		C2H2 Zn finger	373..393	CDD:275368	6/19 (32%)
		C2H2 Zn finger	401..421	CDD:275368	6/19 (32%)
		C2H2 Zn finger	429..449	CDD:275368	7/19 (37%)
		C2H2 Zn finger	457..477	CDD:275368	5/19 (26%)
		C2H2 Zn finger	485..505	CDD:275368	6/19 (32%)
		C2H2 Zn finger	513..533	CDD:275368	8/20 (40%)
		C2H2 Zn finger	541..561	CDD:275368	9/19 (47%)
		C2H2 Zn finger	569..589	CDD:275368	0/19 (0%)
		C2H2 Zn finger	597..617	CDD:275368	7/19 (37%)
		C2H2 Zn finger	625..645	CDD:275368	6/19 (32%)
		C2H2 Zn finger	681..701	CDD:275368
		C2H2 Zn finger	709..729	CDD:275368
		zf-H2C2_2	721..746	CDD:404364
		C2H2 Zn finger	737..757	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	505	1.000	Inparanoid score	I1328
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.950