DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and Zfp709

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_663599.3	Gene:	Zfp709 / 236193	MGIID:	2384299	Length:	727	Species:	Mus musculus

Alignment Length:	535	Identity:	189/535 - (35%)
Similarity:	267/535 - (49%)	Gaps:	36/535 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   218 TGTHVCDICGKMFQFRYQ--LIVHRRYHSERKPFMCQVCGQGFTTSQDLTRHGKIHIGGPMFTCI 280
            |...:| |..:.:.|.|.  |....:.|:.:||:.|:.||:.|:...::.||.:||.|...:.|.
Mouse   193 TREEIC-IDKQHYAFNYPDFLQYVEKVHTGKKPYACKQCGKTFSFLSNIKRHERIHSGEKPYRCN 256

  Fly   281 VCFNVFANNTSLERHMKRHSTDKPFACTICQKTFARKEHLDNHFRSHTGETPFRCQYCAKTFTRK 345
            :|...|..:|:.:.|.:.|:.:||:.||.|.|:|:...::..|.|:||||.|:||..|.|.|:..
Mouse   257 ICDKAFTCSTNFQEHERTHTGEKPYLCTQCGKSFSFLSNIRRHERTHTGEKPYRCNACGKAFSYL 321

  Fly   346 EHMVNHVRKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYTRKEHLANHMRS 410
            .:..:|.|.||||.|:.|..|.|:||....:..|...|||:.|:.|..|||.::....:..|.|.
Mouse   322 TNFQDHERTHTGEKPYVCTQCGKAFTYYYSFQTHKRCHTGEKPYVCKQCGKAFSYYNSIQTHKRC 386

  Fly   411 HTNETPFRCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRC 475
            ||.|.|:.|::|.|:|:.......|...|:||.||.|..|.|.|.....|..|.|.||||.|::|
Mouse   387 HTGEKPYVCKLCAKAFTTLSSLRYHERIHSGEKPHVCLQCGKGFNSSSTLRIHERTHTGEKPYKC 451

  Fly   476 SYCMKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTGESPH----------- 529
            ..|.|.|:....|..|.|.|:||.|:.|..|.|||||...:..|.|.|.||.|:
Mouse   452 KKCGKVFSVDSSLRCHERIHSGEKPYVCKQCGKAFTRHTSLRCHERIHCGEKPYICKQCGKGFIS 516

  Fly   530 -----------------KCTYCTKTFTRKEHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVR 577
                             .|..|.|.||....|..|.|.|:|:.|:.|.:|.|.|:.......|.:
Mouse   517 SSNFRKHEWTHSGEKLCVCKLCGKAFTGHSSLQRHERIHSGEKPYVCKHCGKDFSSLSGCQRHEQ 581

  Fly   578 LHTGDSPHKCEYCQKTFTRKEHLNNHMRQHSSDNPHCCNVCNKPFTRKEHLINHMSRCHTGDRPF 642
            :|||:.|:.|:.|.|.||....|.||.|.||.:.|:.|..|.|.|........| .|.|||::|:
Mouse   582 IHTGEKPYVCKNCGKAFTNPSALRNHERIHSGEKPYVCGQCGKGFISFSKFRIH-ERIHTGEKPY 645

  Fly   643 TCETCGKSFPLKGNLLFHQRSHTKGQEMERPFACEKCPKNFICKGHLVSHMRSHSGEKPHACTLC 707
            .|:.|||:|....:|..|:|.|:.    |:||.|:.|.|:|........|.:.|:||||..|..|
Mouse   646 KCKQCGKAFTGHSSLRRHERIHSG----EKPFVCKHCGKSFYTLSDCQRHEQIHTGEKPFICKQC 706

  Fly   708 SKAFVERGNLKRHMK 722
            .|||....:||.|.|
Mouse   707 GKAFTRSSSLKIHDK 721

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	5/21 (24%)
		C2H2 Zn finger	251..271	CDD:275368	6/19 (32%)
		C2H2 Zn finger	279..299	CDD:275368	5/19 (26%)
		COG5048	300..723	CDD:227381	165/451 (37%)
		C2H2 Zn finger	307..327	CDD:275368	7/19 (37%)
		C2H2 Zn finger	335..355	CDD:275368	6/19 (32%)
		C2H2 Zn finger	363..383	CDD:275368	6/19 (32%)
		C2H2 Zn finger	391..411	CDD:275368	6/19 (32%)
		C2H2 Zn finger	419..439	CDD:275368	5/19 (26%)
		C2H2 Zn finger	447..467	CDD:275368	7/19 (37%)
		C2H2 Zn finger	475..495	CDD:275368	7/19 (37%)
		C2H2 Zn finger	503..523	CDD:275368	9/19 (47%)
		C2H2 Zn finger	531..551	CDD:275368	8/19 (42%)
		C2H2 Zn finger	559..579	CDD:275368	5/19 (26%)
		C2H2 Zn finger	587..607	CDD:275368	9/19 (47%)
		C2H2 Zn finger	615..636	CDD:275368	6/20 (30%)
		C2H2 Zn finger	644..664	CDD:275368	8/19 (42%)
		C2H2 Zn finger	676..696	CDD:275368	5/19 (26%)
		C2H2 Zn finger	704..722	CDD:275368	8/17 (47%)
Zfp709	NP_663599.3	KRAB	4..>44	CDD:214630
		KRAB	4..43	CDD:279668
		C2H2 Zn finger	227..247	CDD:275368	6/19 (32%)
		zf-H2C2_2	239..264	CDD:290200	8/24 (33%)
		COG5048	251..693	CDD:227381	157/446 (35%)
		C2H2 Zn finger	255..275	CDD:275368	5/19 (26%)
		zf-H2C2_2	267..291	CDD:290200	8/23 (35%)
		C2H2 Zn finger	283..303	CDD:275368	7/19 (37%)
		zf-H2C2_2	295..320	CDD:290200	12/24 (50%)
		C2H2 Zn finger	311..331	CDD:275368	6/19 (32%)
		zf-H2C2_2	323..348	CDD:290200	11/24 (46%)
		C2H2 Zn finger	339..359	CDD:275368	6/19 (32%)
		zf-H2C2_2	351..376	CDD:290200	9/24 (38%)
		C2H2 Zn finger	367..387	CDD:275368	6/19 (32%)
		C2H2 Zn finger	395..415	CDD:275368	5/19 (26%)
		C2H2 Zn finger	423..443	CDD:275368	7/19 (37%)
		zf-H2C2_2	436..459	CDD:290200	11/22 (50%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		zf-H2C2_2	463..488	CDD:290200	12/24 (50%)
		C2H2 Zn finger	479..499	CDD:275368	9/19 (47%)
		C2H2 Zn finger	507..527	CDD:275368	0/19 (0%)
		C2H2 Zn finger	535..555	CDD:275368	8/19 (42%)
		zf-H2C2_2	547..572	CDD:290200	10/24 (42%)
		C2H2 Zn finger	563..583	CDD:275368	5/19 (26%)
		zf-H2C2_2	577..600	CDD:290200	9/22 (41%)
		C2H2 Zn finger	591..611	CDD:275368	9/19 (47%)
		C2H2 Zn finger	619..639	CDD:275368	6/20 (30%)
		zf-H2C2_2	632..655	CDD:290200	10/23 (43%)
		C2H2 Zn finger	647..667	CDD:275368	8/19 (42%)
		zf-H2C2_2	659..684	CDD:290200	11/28 (39%)
		C2H2 Zn finger	675..695	CDD:275368	5/19 (26%)
		zf-H2C2_2	687..712	CDD:290200	11/24 (46%)
		C2H2 Zn finger	703..723	CDD:275368	9/19 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	48	1.000	Domainoid score	I11836
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	505	1.000	Inparanoid score	I1328
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.950