DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment crol and Zfp52

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_653098.2	Gene:	Zfp52 / 22710	MGIID:	99199	Length:	724	Species:	Mus musculus

Alignment Length:	530	Identity:	186/530 - (35%)
Similarity:	270/530 - (50%)	Gaps:	33/530 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   223 CDICGKMFQFRYQLIVHRRYHSERKPFMCQVCGQGF----TTSQDLTRH-----------GKI-- 270
            |..|.|.|.....|.:|:|.|:..||:.|.:||:.|    :...|.|.|           ||:
Mouse   188 CGHCRKYFSTTSSLSIHQRIHTGEKPYKCNICGKSFNQWSSLKTDQTLHTAKKPYKCKEGGKLLV 252

  Fly   271 -----------HIGGPMFTCIVCFNVFANNTSLERHMKRHSTDKPFACTICQKTFARKEHLDNHF 324
                       |.|...:.|..|...||:..||..|.|.||.:..:.|..|.|:.....||..|.
Mouse   253 QLSALKSHQRRHTGEKPYKCQQCDRSFAHCASLRWHQKIHSPEIHYECKECGKSCFELSHLKRHC 317

  Fly   325 RSHTGETPFRCQYCAKTFTRKEHMVNHVRKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPH 389
            |.||.|.|:|.:.|..:.|....:..|.:.||.|.|:|...|.||.|:..:...:...|||:.|:
Mouse   318 RIHTAEKPYRYEVCDTSITVNSTLKTHHKIHTREKPYRYRECDKSITKCSYLRTYQRVHTGKRPY 382

  Fly   390 QCDVCGKKYTRKEHLANHMRSHTNETPFRCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTF 454
            :|..|.|.:|:..:|..|.:.||.|.|.:|:.|.|||.|..........|.||..:||..|.::|
Mouse   383 RCTECDKFFTKHSNLRQHQKIHTGEKPPKCKDCDKSFLRISSVRIRQKIHAGERRYRCKECGRSF 447

  Fly   455 TRKEHLLNHVRQHTGESPHRCSYCMKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNH 519
            |...:|..|.|.||||.|:||..|.|:||...:|..|.:.||||.|:||..|..:|....::..|
Mouse   448 TWFSNLRVHQRVHTGERPYRCKECGKSFTTGSNLRVHQKIHTGEKPYKCKDCDISFLWISNLRTH 512

  Fly   520 VRQHTGESPHKCTYCTKTFTRKEHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSP 584
            .:.||||.|:||..|.|:|||..:|.:|.:.|||:..::|..|..:|.....|..|.::|||:.|
Mouse   513 QKIHTGEKPYKCQECNKSFTRCSYLRDHQKIHTGEKLYKCKDCDISFMWISSLRRHQKIHTGEKP 577

  Fly   585 HKCEYCQKTFTRKEHLNNHMRQHSSDNPHCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGK 649
            :||..|:|:||:...|.:|.:.|:.:.|:.|..|...|.....|..| .:.|||::|:.|:.|..
Mouse   578 YKCRGCEKSFTQCSTLRDHQKIHTGEKPYKCKDCGISFLWISSLRRH-QKIHTGEKPYKCKDCDI 641

  Fly   650 SFPLKGNLLFHQRSHTKGQEMERPFACEKCPKNFICKGHLVSHMRSHSGEKPHACTLCSKAFVER 714
            ||....||..||:.||.    |:|:.|::|.|:|....:|..|.|:|||||.:.|..|..:|:..
Mouse   642 SFLWISNLRTHQKIHTG----EKPYKCQECNKSFTRCSYLRVHQRTHSGEKLYKCENCDVSFMWI 702

  Fly   715 GNLKRHMKMN 724
            .||:||.|::
Mouse   703 SNLRRHQKIH 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	7/19 (37%)
		C2H2 Zn finger	251..271	CDD:275368	9/47 (19%)
		C2H2 Zn finger	279..299	CDD:275368	8/19 (42%)
		COG5048	300..723	CDD:227381	155/422 (37%)
		C2H2 Zn finger	307..327	CDD:275368	7/19 (37%)
		C2H2 Zn finger	335..355	CDD:275368	3/19 (16%)
		C2H2 Zn finger	363..383	CDD:275368	4/19 (21%)
		C2H2 Zn finger	391..411	CDD:275368	6/19 (32%)
		C2H2 Zn finger	419..439	CDD:275368	6/19 (32%)
		C2H2 Zn finger	447..467	CDD:275368	7/19 (37%)
		C2H2 Zn finger	475..495	CDD:275368	7/19 (37%)
		C2H2 Zn finger	503..523	CDD:275368	4/19 (21%)
		C2H2 Zn finger	531..551	CDD:275368	8/19 (42%)
		C2H2 Zn finger	559..579	CDD:275368	5/19 (26%)
		C2H2 Zn finger	587..607	CDD:275368	7/19 (37%)
		C2H2 Zn finger	615..636	CDD:275368	5/20 (25%)
		C2H2 Zn finger	644..664	CDD:275368	8/19 (42%)
		C2H2 Zn finger	676..696	CDD:275368	7/19 (37%)
		C2H2 Zn finger	704..722	CDD:275368	7/17 (41%)
Zfp52	NP_653098.2	KRAB	12..52	CDD:366587
		C2H2 Zn finger	134..153	CDD:275368
		COG5048	184..615	CDD:227381	147/426 (35%)
		C2H2 Zn finger	188..208	CDD:275368	7/19 (37%)
		C2H2 Zn finger	216..264	CDD:275368	9/47 (19%)
		C2H2 Zn finger	244..259	CDD:275368	2/14 (14%)
		C2H2 Zn finger	272..292	CDD:275368	8/19 (42%)
		C2H2 Zn finger	300..320	CDD:275368	7/19 (37%)
		C2H2 Zn finger	329..348	CDD:275368	3/18 (17%)
		C2H2 Zn finger	357..376	CDD:275368	4/18 (22%)
		C2H2 Zn finger	384..404	CDD:275368	6/19 (32%)
		C2H2 Zn finger	412..432	CDD:275368	6/19 (32%)
		C2H2 Zn finger	440..460	CDD:275368	7/19 (37%)
		C2H2 Zn finger	468..488	CDD:275368	7/19 (37%)
		C2H2 Zn finger	496..516	CDD:275368	4/19 (21%)
		C2H2 Zn finger	524..544	CDD:275368	8/19 (42%)
		C2H2 Zn finger	552..572	CDD:275368	5/19 (26%)
		C2H2 Zn finger	580..600	CDD:275368	7/19 (37%)
		C2H2 Zn finger	608..628	CDD:275368	5/20 (25%)
		zf-H2C2_2	620..643	CDD:372612	8/23 (35%)
		C2H2 Zn finger	636..656	CDD:275368	8/19 (42%)
		zf-H2C2_2	648..673	CDD:372612	12/28 (43%)
		C2H2 Zn finger	664..684	CDD:275368	7/19 (37%)
		zf-H2C2_5	690..714	CDD:372805	8/23 (35%)
		C2H2 Zn finger	692..712	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	505	1.000	Inparanoid score	I1328
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.950