DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment crol and Zfp51

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_001295252.1	Gene:	Zfp51 / 22709	MGIID:	99198	Length:	781	Species:	Mus musculus

Alignment Length:	533	Identity:	198/533 - (37%)
Similarity:	277/533 - (51%)	Gaps:	34/533 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   221 HVCDICGKMFQFRYQLIVHRRYHSERKPFMCQVCGQGFTTSQDLTRHGKIHIGGPMFTCIVCFNV 285
            |.|..|||.|.....|.||.|.|::.||:.|.||.:.||....|..|.:.|.|...:.|..|...
Mouse   214 HQCGKCGKCFNTSSSLTVHHRIHTKEKPYKCSVCDKSFTQCTHLKIHQRRHTGEKPYKCKECEKS 278

  Fly   286 FANNTSLERHMKRHSTDKPFACTICQKTFA----------------------------RKEHLDN 322
            |...::|:.|.|.|:.:||:.|..|.|:||                            :..||..
Mouse   279 FVQLSALKSHQKLHTGEKPYKCKECDKSFAHYPNFRTHQKIHTSEEHCSCPECGREFHQLSHLRK 343

  Fly   323 HFRSHTGETPFRCQYCAKTFTRKEHMVNHVRKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQT 387
            |:|.||||.|::|..|.::||....:..|.:.||.|..:.|..|.|||....|...||..|||:.
Mouse   344 HYRLHTGEKPYKCNECDRSFTHYASLRWHQKTHTPEIHYECKECGKSFIELSHLKRHYRIHTGEK 408

  Fly   388 PHQCDVCGKKYTRKEHLANHMRSHTNETPFRCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSK 452
            |::|::|.|.:|....|..|.:.||.|.|::|..|.|||....|...|...||||.|:||..|.|
Mouse   409 PYKCEICDKSFTTTTTLKTHQKIHTGEKPYKCRECDKSFIHSSHLRRHQNVHTGERPYRCKECDK 473

  Fly   453 TFTRKEHLLNHVRQHTGESPHRCSYCMKTFTRKEHLVN-HIRQHTGETPFKCTYCTKAFTRKDHM 516
            :|.....|..|.:.||||..::|..|.|:||::.:|.| |.|.||||.|::|..|.|:||....:
Mouse   474 SFHESATLREHEKSHTGEKTYKCRECDKSFTQRAYLRNHHNRVHTGERPYECKECGKSFTTCSTL 538

  Fly   517 VNHVRQHTGESPHKCTYCTKTFTRKEHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTG 581
            ..|...|||:.|:||..|.|:||...:|..|.:.|:|:.|:||..|.|:||....|..|..:|||
Mouse   539 RIHQTIHTGKKPYKCIECGKSFTNNSYLRTHQKVHSGEKPYRCKECDKSFTSCSTLKAHQNIHTG 603

  Fly   582 DSPHKCEYCQKTFTRKEHLNNHMRQHSSDNPHCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCET 646
            :.|:||..|.|:||:..||..|.|.|:.:.|..|..|:|.|.|..||..| .:.|:|::|:.|..
Mouse   604 EKPYKCIECDKSFTQVSHLRTHQRVHTGERPFRCTECDKSFIRSSHLREH-QKIHSGEKPYKCRD 667

  Fly   647 CGKSFPLKGNLLFHQRSHTKGQEMERPFACEKCPKNFICKGHLVSHMRSHSGEKPHACTLCSKAF 711
            |..||....||..||:.||.    |:|:.|.:|.|:|....:..:|.|.|:||||:.|..|.|:|
Mouse   668 CDISFSQISNLRRHQKLHTG----EKPYKCMECDKSFTHNSNFRTHQRVHTGEKPYRCAECDKSF 728

  Fly   712 VERGNLKRHMKMN 724
            .....|:.|.|::
Mouse   729 TRCSYLRAHQKIH 741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	9/19 (47%)
		C2H2 Zn finger	251..271	CDD:275368	7/19 (37%)
		C2H2 Zn finger	279..299	CDD:275368	6/19 (32%)
		COG5048	300..723	CDD:227381	168/451 (37%)
		C2H2 Zn finger	307..327	CDD:275368	9/47 (19%)
		C2H2 Zn finger	335..355	CDD:275368	5/19 (26%)
		C2H2 Zn finger	363..383	CDD:275368	8/19 (42%)
		C2H2 Zn finger	391..411	CDD:275368	6/19 (32%)
		C2H2 Zn finger	419..439	CDD:275368	7/19 (37%)
		C2H2 Zn finger	447..467	CDD:275368	6/19 (32%)
		C2H2 Zn finger	475..495	CDD:275368	9/20 (45%)
		C2H2 Zn finger	503..523	CDD:275368	6/19 (32%)
		C2H2 Zn finger	531..551	CDD:275368	7/19 (37%)
		C2H2 Zn finger	559..579	CDD:275368	7/19 (37%)
		C2H2 Zn finger	587..607	CDD:275368	9/19 (47%)
		C2H2 Zn finger	615..636	CDD:275368	8/20 (40%)
		C2H2 Zn finger	644..664	CDD:275368	8/19 (42%)
		C2H2 Zn finger	676..696	CDD:275368	6/19 (32%)
		C2H2 Zn finger	704..722	CDD:275368	6/17 (35%)
Zfp51	NP_001295252.1	KRAB	42..82	CDD:366587
		C2H2 Zn finger	216..236	CDD:275368	9/19 (47%)
		SFP1	<239..318	CDD:227516	25/78 (32%)
		C2H2 Zn finger	244..264	CDD:275368	7/19 (37%)
		C2H2 Zn finger	272..292	CDD:275368	6/19 (32%)
		C2H2 Zn finger	300..320	CDD:275368	5/19 (26%)
		COG5048	327..749	CDD:227381	162/420 (39%)
		C2H2 Zn finger	356..376	CDD:275368	5/19 (26%)
		C2H2 Zn finger	384..404	CDD:275368	8/19 (42%)
		C2H2 Zn finger	412..432	CDD:275368	6/19 (32%)
		C2H2 Zn finger	440..460	CDD:275368	7/19 (37%)
		C2H2 Zn finger	468..488	CDD:275368	6/19 (32%)
		C2H2 Zn finger	496..517	CDD:275368	9/20 (45%)
		C2H2 Zn finger	525..545	CDD:275368	6/19 (32%)
		C2H2 Zn finger	553..573	CDD:275368	7/19 (37%)
		C2H2 Zn finger	581..601	CDD:275368	7/19 (37%)
		C2H2 Zn finger	609..629	CDD:275368	9/19 (47%)
		C2H2 Zn finger	637..657	CDD:275368	8/20 (40%)
		C2H2 Zn finger	665..685	CDD:275368	8/19 (42%)
		C2H2 Zn finger	693..713	CDD:275368	6/19 (32%)
		C2H2 Zn finger	721..741	CDD:275368	7/19 (37%)
		C2H2 Zn finger	749..769	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	505	1.000	Inparanoid score	I1328
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.950