DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and Zfp40

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_001344626.1	Gene:	Zfp40 / 22700	MGIID:	99185	Length:	796	Species:	Mus musculus

Alignment Length:	584	Identity:	215/584 - (36%)
Similarity:	295/584 - (50%)	Gaps:	48/584 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   223 CDICGKMFQFRYQLIVHRRYHSERKPFMCQVCGQGFTTSQDLTRHGKIHIGGPMFTCIVCFNVFA 287
            |..|||.|:....|..|||.|...||:....|.:..........|..||.|...:.||.|...:
Mouse   227 CRKCGKCFRTYSSLYRHRRTHPGEKPYKLTECNKSILYLSHHKVHYNIHYGEKPYKCIECGKCY- 290

  Fly   288 NNTSLERHMKRHSTDKPFACTICQKTFARKEHLDNHFRSHTGETPFRCQYCAKTFTRKEHMVNHV 352
            .::|.|:|.:.||.::.:.|..|:|:|.....|..|.:.|.||.|:.|:.|:|:|....|:.||.
Mouse   291 YHSSFEKHYRIHSEEESYKCNDCRKSFICCLGLKRHHKIHGGERPYECKQCSKSFYTSSHLENHY 355

  Fly   353 RK---------------------------HTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQ 390
            |.                           |.||..:.|..|.|.|.:|.....|...|||:..::
Mouse   356 RTHRRKLHRCNECGKSLSSSSGLQRHQRIHRGEKAYICAECNKCFIQKSQLKTHQRIHTGEKSYK 420

  Fly   391 CDVCGKKYTRKEHLANHMRSHTNETPFRCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFT 455
            |..|.|.:|....|..|.|.||.|.|::|..|.|.|.::.|...|...||||.|::|..|.|:||
Mouse   421 CSECEKSFTVGSSLRIHQRIHTGEKPYKCSECHKCFIQQAHLRRHQKIHTGEKPYKCSECEKSFT 485

  Fly   456 RKEHLLNHVRQHTGESPHRCSYCMKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHV 520
            ....|..|.:.||||.|::||.|.|.|.:|..|..|.|.||||.|:||:.|.|.||....:..|.
Mouse   486 VGSDLRMHQKIHTGEKPYKCSDCDKCFIQKAKLKKHQRIHTGEKPYKCSECEKCFTVVSDLRTHQ 550

  Fly   521 RQHTGESPHKCTYCTKTFTRKEHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPH 585
            :.||||.|:||:.|.|.|.||.:|..|.|.|||:.|::||.|.|.|.:|.:|..|.|:|||:.|:
Mouse   551 KIHTGEKPYKCSECDKCFIRKANLRRHHRIHTGEKPYKCSDCGKCFIQKANLRTHERIHTGEKPY 615

  Fly   586 KCEYCQKTFTRKEHLNNHMRQHSSDNPHCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGKS 650
            ||| |.|:||....|..|.:.|:.:.|:.|:.|||.|.||.||..| .|.|||::|:.|..|||.
Mouse   616 KCE-CGKSFTVGSDLRKHQKCHTGEKPYKCSECNKCFIRKAHLRRH-QRIHTGEKPYKCSDCGKC 678

  Fly   651 FPLKGNLLFHQRSHTKGQEMERPFACEKCPKNFICKGHLVSHMRSHSGEKPHACTLCSKAFVERG 715
            |..|.||..||:.||.    |:|:.|.:|.|.||.|.||.:|.|.|:||||:.|:.|.|:|....
Mouse   679 FIQKANLRTHQKIHTG----EKPYKCSECDKCFIQKDHLRTHQRLHTGEKPYKCSECEKSFTGGS 739

  Fly   716 NLKRHMKMNH----PDAMMPPPPVHPHPQIPAGVLTQVKQEVKPIIIPHHSATTTMHTIQQITA 775
            .|::|.|::.    .:||....|:...|     .|..:|:     .|...|....|:..|.:.|
Mouse   740 VLRKHQKIHTARSLTNAMNLTNPLSKKP-----TLELIKE-----FIQESSLLNAMYIAQSLPA 793

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	9/19 (47%)
		C2H2 Zn finger	251..271	CDD:275368	2/19 (11%)
		C2H2 Zn finger	279..299	CDD:275368	6/19 (32%)
		COG5048	300..723	CDD:227381	179/449 (40%)
		C2H2 Zn finger	307..327	CDD:275368	6/19 (32%)
		C2H2 Zn finger	335..355	CDD:275368	8/46 (17%)
		C2H2 Zn finger	363..383	CDD:275368	6/19 (32%)
		C2H2 Zn finger	391..411	CDD:275368	7/19 (37%)
		C2H2 Zn finger	419..439	CDD:275368	6/19 (32%)
		C2H2 Zn finger	447..467	CDD:275368	7/19 (37%)
		C2H2 Zn finger	475..495	CDD:275368	9/19 (47%)
		C2H2 Zn finger	503..523	CDD:275368	6/19 (32%)
		C2H2 Zn finger	531..551	CDD:275368	9/19 (47%)
		C2H2 Zn finger	559..579	CDD:275368	9/19 (47%)
		C2H2 Zn finger	587..607	CDD:275368	8/19 (42%)
		C2H2 Zn finger	615..636	CDD:275368	11/20 (55%)
		C2H2 Zn finger	644..664	CDD:275368	10/19 (53%)
		C2H2 Zn finger	676..696	CDD:275368	10/19 (53%)
		C2H2 Zn finger	704..722	CDD:275368	6/17 (35%)
Zfp40	NP_001344626.1	KRAB	42..82	CDD:307490
		C2H2 Zn finger	227..247	CDD:275368	9/19 (47%)
		C2H2 Zn finger	255..275	CDD:275368	2/19 (11%)
		COG5048	279..677	CDD:227381	153/400 (38%)
		C2H2 Zn finger	283..302	CDD:275368	6/19 (32%)
		C2H2 Zn finger	310..330	CDD:275368	6/19 (32%)
		C2H2 Zn finger	338..358	CDD:275368	8/19 (42%)
		C2H2 Zn finger	365..385	CDD:275368	0/19 (0%)
		C2H2 Zn finger	393..413	CDD:275368	6/19 (32%)
		C2H2 Zn finger	421..441	CDD:275368	7/19 (37%)
		C2H2 Zn finger	449..469	CDD:275368	6/19 (32%)
		C2H2 Zn finger	477..497	CDD:275368	7/19 (37%)
		C2H2 Zn finger	505..525	CDD:275368	9/19 (47%)
		C2H2 Zn finger	533..553	CDD:275368	6/19 (32%)
		C2H2 Zn finger	561..581	CDD:275368	9/19 (47%)
		C2H2 Zn finger	589..609	CDD:275368	9/19 (47%)
		C2H2 Zn finger	618..636	CDD:275368	7/18 (39%)
		C2H2 Zn finger	644..664	CDD:275368	11/20 (55%)
		C2H2 Zn finger	672..692	CDD:275368	10/19 (53%)
		zf-H2C2_2	684..709	CDD:316026	12/28 (43%)
		C2H2 Zn finger	700..720	CDD:275368	10/19 (53%)
		C2H2 Zn finger	728..748	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	505	1.000	Inparanoid score	I1328
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.860