DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment crol and Zfp729a

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_898969.2	Gene:	Zfp729a / 212281	MGIID:	3036250	Length:	973	Species:	Mus musculus

Alignment Length:	558	Identity:	194/558 - (34%)
Similarity:	271/558 - (48%)	Gaps:	60/558 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   223 CDICGKMFQFRYQLIVHRRYHSERKPFMCQVCGQGFTTSQDLTRHGKIHIGGPMFTCIVCFNVFA 287
            |::|||.|.|...|:||:|.|:..||:.|::|.:.|.....|::|.:||.|...:.|..|...|.
Mouse   205 CEVCGKAFHFPSLLLVHKRVHTGEKPYKCEICDKAFHYPSILSKHKRIHTGEKPYKCEECGKAFH 269

  Fly   288 NNTSLERHMKRHSTDKPFACTICQKTFARKEHLDNHFRSHTGETPFRCQYCAKTFTRKEHMVNHV 352
            .::.|.:|...|..:||:.|.:|.|.|.....|.||.:.|:||.||:|:.|.|.|.....:..|.
Mouse   270 ISSFLSKHKIIHRGEKPYKCEVCGKAFHYPSRLSNHKKIHSGEKPFKCEVCGKAFRILSLLSKHK 334

  Fly   353 RKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYTRKEHLANHMRSHT----- 412
            ..||.|.|::|::|.|:|........|...|||:.|::|:||.|.:.....|:.|.|.||
Mouse   335 IIHTEENPYKCEVCGKAFDYPSRLSTHAKMHTGEKPYKCEVCQKAFRSLSSLSKHKRIHTEDNYY 399

  Fly   413 -----------------------NETPFRCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTF 454
                                   .|.|::||:|||:|......:.|...||||..::|:.|.|.|
Mouse   400 NNELCGKAFIYPSRLSKHKRICAGEKPYKCEVCGKAFHVSSLLSKHRTIHTGEKLYKCEVCGKAF 464

  Fly   455 TRKEHLLNHVRQHTGESPHRCSYCMKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNH 519
            .....|.||.:.||||.|.:|..|.|.|.....|..|.|.||||.|:||..|.|||.....:..|
Mouse   465 YYPSRLSNHKKIHTGEKPFQCEVCGKAFCFPSSLSKHKRIHTGEKPYKCKECGKAFRSLSSLSKH 529

  Fly   520 VRQHTGESPHKCTYCTKTFTRKEHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSP 584
            .|.||||.|:||..|.|.|.....|:.|...||.:.|::|..|.:.|.....|::|..:|||:.|
Mouse   530 KRIHTGEKPYKCEECGKAFHYPSLLSKHKIIHTEEKPYKCDVCGQAFHVPSKLSHHKIIHTGEKP 594

  Fly   585 HKCEYCQKTFTRKEHLNNHMRQHSSDNPHCCNVCNKPFTRKEHLINHMS--------RC------ 635
            :|||.|.|.|.....|:.|.|.|:.:||:...||:|.|.....|..|..        :|
Mouse   595 YKCEVCGKAFCIPLLLSKHKRVHTGENPYNSQVCSKAFVYPSKLSKHKKVRTKEKPYKCEVCGKA 659

  Fly   636 -------------HTGDRPFTCETCGKSFPLKGNLLFHQRSHTKGQEMERPFACEKCPKNFICKG 687
                         |||::|:.||.|||:|.....|..|:|.||.    |:|:.||.|.|:|....
Mouse   660 FRFPSLLLIHKGMHTGEKPYKCEDCGKAFHYPSLLSKHKRIHTG----EKPYQCEVCGKDFHVSS 720

  Fly   688 HLVSHMRSHSGEKPHACTLCSKAFVERGNLKRHMKMNH 725
            .|..|...|:||||:.|.:|.|.|....:|.:| |.||
Mouse   721 SLSKHRIIHTGEKPYKCEICGKTFRFSSSLSKH-KRNH 757

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	10/19 (53%)
		C2H2 Zn finger	251..271	CDD:275368	5/19 (26%)
		C2H2 Zn finger	279..299	CDD:275368	5/19 (26%)
		COG5048	300..723	CDD:227381	164/477 (34%)
		C2H2 Zn finger	307..327	CDD:275368	7/19 (37%)
		C2H2 Zn finger	335..355	CDD:275368	5/19 (26%)
		C2H2 Zn finger	363..383	CDD:275368	5/19 (26%)
		C2H2 Zn finger	391..411	CDD:275368	7/19 (37%)
		C2H2 Zn finger	419..439	CDD:275368	7/19 (37%)
		C2H2 Zn finger	447..467	CDD:275368	7/19 (37%)
		C2H2 Zn finger	475..495	CDD:275368	7/19 (37%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
		C2H2 Zn finger	531..551	CDD:275368	6/19 (32%)
		C2H2 Zn finger	559..579	CDD:275368	5/19 (26%)
		C2H2 Zn finger	587..607	CDD:275368	8/19 (42%)
		C2H2 Zn finger	615..636	CDD:275368	7/47 (15%)
		C2H2 Zn finger	644..664	CDD:275368	9/19 (47%)
		C2H2 Zn finger	676..696	CDD:275368	7/19 (37%)
		C2H2 Zn finger	704..722	CDD:275368	6/17 (35%)
Zfp729a	NP_898969.2	KRAB	15..73	CDD:214630
		KRAB	15..54	CDD:279668
		C2H2 Zn finger	93..110	CDD:275368
		C2H2 Zn finger	121..141	CDD:275368
		C2H2 Zn finger	149..169	CDD:275368
		C2H2 Zn finger	177..197	CDD:275368
		zf-H2C2_2	190..213	CDD:290200	4/7 (57%)
		C2H2 Zn finger	205..225	CDD:275368	10/19 (53%)
		zf-H2C2_2	218..242	CDD:290200	10/23 (43%)
		COG5048	229..670	CDD:227381	145/440 (33%)
		C2H2 Zn finger	233..253	CDD:275368	5/19 (26%)
		zf-H2C2_2	246..269	CDD:290200	7/22 (32%)
		C2H2 Zn finger	261..281	CDD:275368	5/19 (26%)
		C2H2 Zn finger	289..309	CDD:275368	7/19 (37%)
		zf-H2C2_2	302..324	CDD:290200	11/21 (52%)
		C2H2 Zn finger	317..337	CDD:275368	5/19 (26%)
		C2H2 Zn finger	345..365	CDD:275368	5/19 (26%)
		C2H2 Zn finger	373..393	CDD:275368	7/19 (37%)
		C2H2 Zn finger	404..421	CDD:275368	0/16 (0%)
		C2H2 Zn finger	429..449	CDD:275368	7/19 (37%)
		C2H2 Zn finger	457..477	CDD:275368	7/19 (37%)
		zf-H2C2_2	470..492	CDD:290200	11/21 (52%)
		C2H2 Zn finger	485..505	CDD:275368	7/19 (37%)
		zf-H2C2_2	497..522	CDD:290200	14/24 (58%)
		COG5048	509..951	CDD:227381	90/254 (35%)
		C2H2 Zn finger	513..533	CDD:275368	7/19 (37%)
		zf-H2C2_2	525..550	CDD:290200	12/24 (50%)
		C2H2 Zn finger	541..561	CDD:275368	6/19 (32%)
		C2H2 Zn finger	569..589	CDD:275368	5/19 (26%)
		C2H2 Zn finger	597..617	CDD:275368	8/19 (42%)
		C2H2 Zn finger	626..645	CDD:275368	6/18 (33%)
		C2H2 Zn finger	653..673	CDD:275368	1/19 (5%)
		C2H2 Zn finger	681..701	CDD:275368	9/19 (47%)
		zf-H2C2_2	694..717	CDD:290200	11/26 (42%)
		C2H2 Zn finger	709..729	CDD:275368	7/19 (37%)
		zf-H2C2_2	721..744	CDD:290200	10/22 (45%)
		C2H2 Zn finger	737..757	CDD:275368	7/20 (35%)
		zf-H2C2_2	749..773	CDD:290200	5/10 (50%)
		C2H2 Zn finger	765..785	CDD:275368
		C2H2 Zn finger	793..813	CDD:275368
		zf-H2C2_2	806..830	CDD:290200
		C2H2 Zn finger	821..841	CDD:275368
		C2H2 Zn finger	849..869	CDD:275368
		zf-H2C2_2	861..886	CDD:290200
		C2H2 Zn finger	877..897	CDD:275368
		zf-H2C2_2	890..914	CDD:290200
		C2H2 Zn finger	905..925	CDD:275368
		C2H2 Zn finger	933..953	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	505	1.000	Inparanoid score	I1328
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.950