DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZNF626

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_001070143.1	Gene:	ZNF626 / 199777	HGNCID:	30461	Length:	528	Species:	Homo sapiens

Alignment Length:	483	Identity:	159/483 - (32%)
Similarity:	225/483 - (46%)	Gaps:	71/483 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   234 YQLIVHRRY----HSE---RKPFM----CQVCGQGFT-TSQDLTRHGKIHIGGPMFTC-----IV 281
            :|.:|.|||    |..   :|..:    |:|..:|:. .:|.||.       .|...|     :.
Human    95 FQKVVLRRYEKCEHDNLQLKKGCISVDECKVHKEGYNELNQCLTT-------TPRKICQCDKYVK 152

  Fly   282 CFNVFANNTSLERHMKRHSTDKPFACTICQKTFARKEHLDNHFRSHTGETPFRCQYCAKTFTRKE 346
            ..:.|.|:...:|   .|:..|||....|.|.|.:...|..|.:.|||..|::|:.|.|.|....
Human   153 VLHQFPNSNGQKR---GHTGKKPFKYIECGKAFKQFSTLTTHKKIHTGGKPYKCEECGKAFNHSC 214

  Fly   347 HMVNHVRKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYTRKEHLANHMRSH 411
            .:..|.:.||||.|::|:.|.|:|........|...|||:.|::||.|||.:.....|:.|...|
Human   215 SLTRHKKIHTGEKPYKCEECGKAFKHSSTLTTHKRNHTGEKPYKCDKCGKAFMSSSTLSKHEIIH 279

  Fly   412 TNETPFRCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRCS 476
            |.:.|::||.|||:|:|....|.|.:.||||.|::|:.|.|.|.....|..|.|.||.:.|::|.
Human   280 TEKKPYKCEECGKAFNRSSTLTTHKIIHTGEKPYKCEECDKAFKYSYTLTTHKRIHTEDKPYKCE 344

  Fly   477 YCMKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTGESPHKCTYCTKTFTRK 541
            .|.|.|.....|..|.|.||||.|:||..|.|||.|...:..|...||||.|:||..|.|.|...
Human   345 ECGKAFKYSSTLTTHKRIHTGEKPYKCEECGKAFKRSSDLTTHKIIHTGEKPYKCEECGKAFKYS 409

  Fly   542 EHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTFTRKEHLNNHMRQ 606
            .:||.|.:.|||:.|::|..|.|.|.:...||.|.|:|||:..:|||.|.|.|....:|..|
Human   410 SNLTTHKKIHTGERPYKCEECGKAFNQSSILTTHRRIHTGEKFYKCEECGKAFKCSSNLTTH--- 471

  Fly   607 HSSDNPHCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGKSFPLKGNLLFH-----QRSHTK 666
                                      .:.|||:||:.||.|||:|.....|..|     :|:.|.
Human   472 --------------------------KKIHTGERPYKCEECGKAFNQSSILTTHERIILERNSTN 510

  Fly   667 GQEMERPFACEKCPKNFICKGHLVSHMR 694
            .:.:.:|.:          ..|.:.|:|
Human   511 VKNVAKPSS----------GPHTLLHIR 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	5/12 (42%)
		C2H2 Zn finger	251..271	CDD:275368	6/20 (30%)
		C2H2 Zn finger	279..299	CDD:275368	4/24 (17%)
		COG5048	300..723	CDD:227381	140/400 (35%)
		C2H2 Zn finger	307..327	CDD:275368	5/19 (26%)
		C2H2 Zn finger	335..355	CDD:275368	5/19 (26%)
		C2H2 Zn finger	363..383	CDD:275368	5/19 (26%)
		C2H2 Zn finger	391..411	CDD:275368	7/19 (37%)
		C2H2 Zn finger	419..439	CDD:275368	9/19 (47%)
		C2H2 Zn finger	447..467	CDD:275368	7/19 (37%)
		C2H2 Zn finger	475..495	CDD:275368	7/19 (37%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
		C2H2 Zn finger	531..551	CDD:275368	7/19 (37%)
		C2H2 Zn finger	559..579	CDD:275368	8/19 (42%)
		C2H2 Zn finger	587..607	CDD:275368	7/19 (37%)
		C2H2 Zn finger	615..636	CDD:275368	0/20 (0%)
		C2H2 Zn finger	644..664	CDD:275368	9/24 (38%)
		C2H2 Zn finger	676..696	CDD:275368	3/19 (16%)
		C2H2 Zn finger	704..722	CDD:275368
ZNF626	NP_001070143.1	KRAB	4..62	CDD:214630
		KRAB	6..43	CDD:279668
		C2H2 Zn finger	177..195	CDD:275368	5/17 (29%)
		zf-H2C2_2	188..212	CDD:290200	10/23 (43%)
		COG5048	199..520	CDD:227381	126/359 (35%)
		C2H2 Zn finger	203..223	CDD:275368	5/19 (26%)
		zf-H2C2_2	215..240	CDD:290200	10/24 (42%)
		C2H2 Zn finger	231..251	CDD:275368	5/19 (26%)
		zf-H2C2_2	244..266	CDD:290200	10/21 (48%)
		C2H2 Zn finger	259..279	CDD:275368	7/19 (37%)
		zf-H2C2_2	272..296	CDD:290200	11/23 (48%)
		C2H2 Zn finger	287..307	CDD:275368	9/19 (47%)
		zf-H2C2_2	300..324	CDD:290200	11/23 (48%)
		C2H2 Zn finger	315..335	CDD:275368	7/19 (37%)
		zf-H2C2_2	328..352	CDD:290200	10/23 (43%)
		C2H2 Zn finger	343..363	CDD:275368	7/19 (37%)
		zf-H2C2_2	356..380	CDD:290200	14/23 (61%)
		C2H2 Zn finger	371..391	CDD:275368	7/19 (37%)
		zf-H2C2_2	383..408	CDD:290200	11/24 (46%)
		C2H2 Zn finger	399..419	CDD:275368	7/19 (37%)
		zf-H2C2_2	411..436	CDD:290200	11/24 (46%)
		C2H2 Zn finger	427..447	CDD:275368	8/19 (42%)
		zf-H2C2_2	440..464	CDD:290200	13/23 (57%)
		C2H2 Zn finger	455..475	CDD:275368	7/48 (15%)
		zf-H2C2_2	467..492	CDD:290200	13/53 (25%)
		C2H2 Zn finger	483..502	CDD:275368	8/18 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810