DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and Maz

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_001359451.1	Gene:	Maz / 17188	MGIID:	1338823	Length:	493	Species:	Mus musculus

Alignment Length:	415	Identity:	115/415 - (27%)
Similarity:	168/415 - (40%)	Gaps:	99/415 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 QLPPPPPLPPQVTSHAASAAAAAAAASTNNAAVAAVMASANAAAAAAAAASAGGGLPPATSGNG- 150
            |.|.|||.||.|::.||.||..||||:...||..||:|..:..|.|..|:.    |...|...|
Mouse   129 QPPAPPPPPPAVSAPAAEAAPPAAAATIAAAAATAVVAPTSTVAVAPVASV----LEKKTKSKGP 189

  Fly   151 ------------GQQVTVTTTSSSTSSGGSTTSGG----TTTTAGELLMPKMEGGIHGVDGSGNG 199
                        |..:.......:.:..|...||.    |......|.:|::.|   ...|.|..
Mouse   190 YICALCAKEFKNGYNLRRHEAIHTGAKAGRVPSGAMKMPTMVPLSLLSVPQLSG---ASGGGGEA 251

  Fly   200 GNGGGQNVALAPDG--TPIATG-----THVCDICGKMFQFRYQLIVHRRYHSERKPFMCQVCGQG 257
            |.||| ..|:|..|  |..|:|     .|.|::|||.|:..|.
Mouse   252 GAGGG-TAAVAAGGVVTTTASGKRIRKNHACEMCGKAFRDVYH---------------------- 293

  Fly   258 FTTSQDLTRHGKIHIGGPMFTCIVCFNVFANNTSLERHMKRHSTDKPFACTICQKTFARKEHLDN 322
                                              |.||...||.:||:.|.:||:.|.||:.:..
Mouse   294 ----------------------------------LNRHKLSHSDEKPYQCPVCQQRFKRKDRMSY 324

  Fly   323 HFRSHTG--ETPFRCQYCAKTFTRKEHMVNHVRK-HTGETPHRCDICKKSFTRKEHYVNHYMWHT 384
            |.|||.|  ..|:.|.:|.|:|:|.:|:.:|||: |:.|.|.:|:.|:.:|..|:....|.:.|.
Mouse   325 HVRSHDGAVHKPYNCSHCGKSFSRPDHLNSHVRQVHSTERPFKCEKCEAAFATKDRLRAHTVRHE 389

  Fly   385 GQTPHQCDVCGKKYTRKEHLANHMRSHTNETPFRCEICGKSFSRKEHFTNHILWHTG-ETPHR-- 446
            .:.|  |.||||..: ..::::||:.|:......||:|.|.|:...:...|.:...| :.|..
Mouse   390 EKVP--CHVCGKMLS-SAYISDHMKVHSQGPHHVCELCNKGFTTAAYLRIHAVKDHGLQAPRADR 451

  Fly   447 --CDFCSKTFTRKEHLLNHVRQHTG 469
              |..||........|..|::.|.|
Mouse   452 ILCKLCSVHCKTPAQLAGHMQTHLG 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	6/19 (32%)
		C2H2 Zn finger	251..271	CDD:275368	0/19 (0%)
		C2H2 Zn finger	279..299	CDD:275368	3/19 (16%)
		COG5048	300..723	CDD:227381	57/178 (32%)
		C2H2 Zn finger	307..327	CDD:275368	8/19 (42%)
		C2H2 Zn finger	335..355	CDD:275368	9/20 (45%)
		C2H2 Zn finger	363..383	CDD:275368	5/19 (26%)
		C2H2 Zn finger	391..411	CDD:275368	7/19 (37%)
		C2H2 Zn finger	419..439	CDD:275368	6/19 (32%)
		C2H2 Zn finger	447..467	CDD:275368	5/19 (26%)
		C2H2 Zn finger	475..495	CDD:275368
		C2H2 Zn finger	503..523	CDD:275368
		C2H2 Zn finger	531..551	CDD:275368
		C2H2 Zn finger	559..579	CDD:275368
		C2H2 Zn finger	587..607	CDD:275368
		C2H2 Zn finger	615..636	CDD:275368
		C2H2 Zn finger	644..664	CDD:275368
		C2H2 Zn finger	676..696	CDD:275368
		C2H2 Zn finger	704..722	CDD:275368
Maz	NP_001359451.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	59..78
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	121..144		8/14 (57%)
		C2H2 Zn finger	192..212	CDD:275368	1/19 (5%)
		C2H2 Zn finger	281..301	CDD:275368	9/75 (12%)
		SFP1	<303..360	CDD:227516	23/56 (41%)
		C2H2 Zn finger	309..329	CDD:275368	8/19 (42%)
		C2H2 Zn finger	339..357	CDD:275368	7/17 (41%)
		C2H2 Zn finger	368..388	CDD:275368	5/19 (26%)
		C2H2 Zn finger	394..413	CDD:275368	7/19 (37%)
		C2H2 Zn finger	421..437	CDD:275368	5/15 (33%)
		C2H2 Zn finger	454..474	CDD:275368	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23226
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100