DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZNF675

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_612203.2	Gene:	ZNF675 / 171392	HGNCID:	30768	Length:	568	Species:	Homo sapiens

Alignment Length:	520	Identity:	180/520 - (34%)
Similarity:	252/520 - (48%)	Gaps:	51/520 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   224 DICGKMFQFRYQLIVHRRYHSERKPFMCQVCGQGFTTSQD---------LTRHG----------- 268
            |:...:.|.:..|.|.|.......|.||....|.|...|:         |.|:.
Human    51 DLITCLEQEKEPLTVKRHEMVNEPPVMCSHFAQEFWPEQNIKDSFEKVTLRRYEKCGNDNFQLKG 115

  Fly   269 -------KIHIGG-------------PMFTC---IVCFNVFANNTSLERHMKRHSTDKPFACTIC 310
                   |:|.||             .||.|   :..||.|:::   :||..:|..:|||.|..|
Human   116 CKSVDECKLHKGGYNGLNQCLPTMQSKMFQCDKYVKVFNKFSHS---DRHKIKHMENKPFKCKEC 177

  Fly   311 QKTFARKEHLDNHFRSHTGETPFRCQYCAKTFTRKEHMVNHVRKHTGETPHRCDICKKSFTRKEH 375
            .::|....||..|.|::|.....:|:.|.|...:...:..|.|.:|.|..::|..|.::|.:..:
Human   178 GRSFCMLSHLTRHERNYTKVNFCKCEECEKAVNQSSKLTKHKRIYTCEKLYKCQECDRTFNQFSN 242

  Fly   376 YVNHYMWHTGQTPHQCDVCGKKYTRKEHLANHMRSHTNETPFRCEICGKSFSRKEHFTNHILWHT 440
            ...:...:..:.|::|:.|||.:.:..||..|...||.|.|::||.|||:|::..:.|.|...||
Human   243 LTEYKKDYAREKPYKCEECGKAFNQSSHLTTHKIIHTGEKPYKCEECGKAFNQFSNLTTHKKIHT 307

  Fly   441 GETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRCSYCMKTFTRKEHLVNHIRQHTGETPFKCTY 505
            ||.|:.|:.|.|.||:...|..|.|.||||.|::|..|.|.|.|...|..|...||||.|:||..
Human   308 GEQPYICEECGKAFTQSSTLTTHKRIHTGEKPYKCEECGKAFNRSSKLTEHKNIHTGEQPYKCEE 372

  Fly   506 CTKAFTRKDHMVNHVRQHTGESPHKCTYCTKTFTRKEHLTNHVRQHTGDSPHRCSYCKKTFTRKE 570
            |.|||.|..::..|.:.||.|.|:||..|.|.|.....||.|.|.|||:.|::|..|.|.|.|..
Human   373 CGKAFNRSSNLTEHRKIHTEEKPYKCKECGKAFKHSSALTTHKRIHTGEKPYKCEECGKAFNRSS 437

  Fly   571 HLTNHVRLHTGDSPHKCEYCQKTFTRKEHLNNHMRQHSSDNPHCCNVCNKPFTRKEHLINHMSRC 635
            .||.|.:||||..|:|||.|.|.|.:...|..|.:.||.:.|:.|..|.|.|.....|..| .|.
Human   438 KLTEHKKLHTGKKPYKCEECGKAFIQSSKLTEHKKIHSGEIPYKCEECGKAFKHSSSLTTH-KRI 501

  Fly   636 HTGDRPFTCETCGKSFPLKGNLLFHQRSHTKGQEMERPFACEKCPKNFICKGHLVSHMRSHSGEK 700
            |||::|:.||.|||:|.....|..|:..||.    |:|:.||:|.|.|....:|..|.:.|:|||
Human   502 HTGEKPYKCEECGKAFSRSSKLTEHKIIHTG----EKPYKCERCDKAFNQSANLTKHKKIHTGEK 562

Fly 701 700
Human 563 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	5/18 (28%)
		C2H2 Zn finger	251..271	CDD:275368	7/46 (15%)
		C2H2 Zn finger	279..299	CDD:275368	6/22 (27%)
		COG5048	300..723	CDD:227381	154/401 (38%)
		C2H2 Zn finger	307..327	CDD:275368	7/19 (37%)
		C2H2 Zn finger	335..355	CDD:275368	5/19 (26%)
		C2H2 Zn finger	363..383	CDD:275368	3/19 (16%)
		C2H2 Zn finger	391..411	CDD:275368	7/19 (37%)
		C2H2 Zn finger	419..439	CDD:275368	8/19 (42%)
		C2H2 Zn finger	447..467	CDD:275368	8/19 (42%)
		C2H2 Zn finger	475..495	CDD:275368	7/19 (37%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
		C2H2 Zn finger	531..551	CDD:275368	8/19 (42%)
		C2H2 Zn finger	559..579	CDD:275368	8/19 (42%)
		C2H2 Zn finger	587..607	CDD:275368	7/19 (37%)
		C2H2 Zn finger	615..636	CDD:275368	7/20 (35%)
		C2H2 Zn finger	644..664	CDD:275368	8/19 (42%)
		C2H2 Zn finger	676..696	CDD:275368	7/19 (37%)
		C2H2 Zn finger	704..722	CDD:275368
ZNF675	NP_612203.2	KRAB	4..62	CDD:214630	2/10 (20%)
		KRAB	4..43	CDD:279668
		COG5048	169..556	CDD:227381	150/391 (38%)
		C2H2 Zn finger	174..194	CDD:275370	7/19 (37%)
		C2H2 Zn finger	202..222	CDD:275368	5/19 (26%)
		C2H2 Zn finger	230..250	CDD:275368	3/19 (16%)
		C2H2 Zn finger	258..278	CDD:275368	7/19 (37%)
		zf-H2C2_2	270..295	CDD:290200	13/24 (54%)
		C2H2 Zn finger	286..306	CDD:275368	8/19 (42%)
		C2H2 Zn finger	314..334	CDD:275368	8/19 (42%)
		zf-H2C2_2	327..351	CDD:290200	12/23 (52%)
		C2H2 Zn finger	342..362	CDD:275368	7/19 (37%)
		C2H2 Zn finger	370..390	CDD:275368	7/19 (37%)
		zf-H2C2_2	382..407	CDD:290200	10/24 (42%)
		C2H2 Zn finger	398..418	CDD:275368	8/19 (42%)
		zf-H2C2_2	410..435	CDD:290200	12/24 (50%)
		C2H2 Zn finger	426..446	CDD:275368	8/19 (42%)
		C2H2 Zn finger	454..474	CDD:275368	7/19 (37%)
		C2H2 Zn finger	482..502	CDD:275368	7/20 (35%)
		zf-H2C2_2	494..519	CDD:290200	13/25 (52%)
		C2H2 Zn finger	510..530	CDD:275368	8/19 (42%)
		C2H2 Zn finger	538..558	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900