DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZNF676

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_001001411.2	Gene:	ZNF676 / 163223	HGNCID:	20429	Length:	588	Species:	Homo sapiens

Alignment Length:	530	Identity:	182/530 - (34%)
Similarity:	249/530 - (46%)	Gaps:	44/530 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   228 KMFQFRYQLIVHRRYH---SERKPFMCQVCGQGFT-TSQDL-TRHGKIHIGGPMFTCIVCFNVFA 287
            ||...||....|...|   |......|.|..:|:. .:|.| |...|:      |.|....|||.
Human    65 KMILRRYDKCGHENLHLKISCTNVDECNVHKEGYNKLNQSLTTTQSKV------FQCGKYANVFH 123

  Fly   288 NNTSLERHMKRHSTDKPFACTICQKTFARKEHLDNHFR--------------------------- 325
            ..::..||..||:.:|...|....::|....||..|.|
Human   124 KCSNSNRHKIRHTGEKGLKCKEYVRSFCMLSHLSQHERIYTRENSYKCEENGKAFNWSSTLTYYK 188

  Fly   326 -SHTGETPFRCQYCAKTFTRKEHMVNHVRKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPH 389
             .||||.|::|:.|.|.|::...:..|...||||.|::|:.|.|:|.|......|.:.|||:.|:
Human   189 SIHTGEKPYKCEECGKAFSKFSILTKHKVIHTGEKPYKCEECGKAFNRSSILTKHKIIHTGEKPY 253

  Fly   390 QCDVCGKKYTRKEHLANHMRSHTNETPFRCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTF 454
            :|:.|||.::....|..|...|..|.|::||.|||:.:.......|...||||.|::|:.|.|.|
Human   254 KCEECGKGFSSVSTLNTHKAIHAEEKPYKCEECGKASNSSSKLMEHKRIHTGEKPYKCEECGKAF 318

  Fly   455 TRKEHLLNHVRQHTGESPHRCSYCMKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNH 519
            :....|..|.|.|.||.|::|..|.|.|.|...|..|...||||.|:||..|.|||::...:..|
Human   319 SWSSSLTEHKRIHAGEKPYKCEECGKAFNRSSILTKHKIIHTGEKPYKCEGCGKAFSKVSTLNTH 383

  Fly   520 VRQHTGESPHKCTYCTKTFTRKEHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSP 584
            ...|..|.|:||..|.|.......|..|.|.|||:.|::|..|.|.|:....||.|.|:|.|:.|
Human   384 KAIHAEEKPYKCEECGKASNSSSKLMEHKRIHTGEKPYKCEECGKAFSWSSSLTEHKRIHAGEKP 448

  Fly   585 HKCEYCQKTFTRKEHLNNHMRQHSSDNPHCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGK 649
            :|||.|.|.||.......|.|.|:::.|:.|..|.|.|:....|..| ...|||::.:.||.|||
Human   449 YKCEECGKAFTWSSSFTKHKRIHAAEKPYKCEECGKGFSTFSILTKH-KIIHTGEKRYKCEECGK 512

  Fly   650 SFPLKGNLLFHQRSHTKGQEMERPFACEKCPKNFICKGHLVSHMRSHSGEKPHACTLCSKAFVER 714
            :|.....|..|:..||.    |:|:.||:|.|.|.....|..|.|.|:||||:.|..|.|||...
Human   513 AFSWSSILTEHKIIHTG----EKPYKCEECGKAFSRSSSLTRHKRIHTGEKPYKCEECGKAFKSS 573

  Fly   715 GNLKRHMKMN 724
            ..:..|.|::
Human   574 STVSYHKKIH 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	5/14 (36%)
		C2H2 Zn finger	251..271	CDD:275368	7/21 (33%)
		C2H2 Zn finger	279..299	CDD:275368	6/19 (32%)
		COG5048	300..723	CDD:227381	158/450 (35%)
		C2H2 Zn finger	307..327	CDD:275368	6/47 (13%)
		C2H2 Zn finger	335..355	CDD:275368	5/19 (26%)
		C2H2 Zn finger	363..383	CDD:275368	6/19 (32%)
		C2H2 Zn finger	391..411	CDD:275368	6/19 (32%)
		C2H2 Zn finger	419..439	CDD:275368	6/19 (32%)
		C2H2 Zn finger	447..467	CDD:275368	7/19 (37%)
		C2H2 Zn finger	475..495	CDD:275368	7/19 (37%)
		C2H2 Zn finger	503..523	CDD:275368	6/19 (32%)
		C2H2 Zn finger	531..551	CDD:275368	6/19 (32%)
		C2H2 Zn finger	559..579	CDD:275368	8/19 (42%)
		C2H2 Zn finger	587..607	CDD:275368	8/19 (42%)
		C2H2 Zn finger	615..636	CDD:275368	6/20 (30%)
		C2H2 Zn finger	644..664	CDD:275368	8/19 (42%)
		C2H2 Zn finger	676..696	CDD:275368	8/19 (42%)
		C2H2 Zn finger	704..722	CDD:275368	6/17 (35%)
ZNF676	NP_001001411.2	KRAB	<1..32	CDD:214630
		C2H2 Zn finger	114..135	CDD:275370	6/20 (30%)
		C2H2 Zn finger	143..163	CDD:275368	6/19 (32%)
		C2H2 Zn finger	171..191	CDD:275368	0/19 (0%)
		COG5048	195..580	CDD:227381	146/389 (38%)
		C2H2 Zn finger	199..219	CDD:275368	5/19 (26%)
		zf-H2C2_2	212..236	CDD:290200	10/23 (43%)
		C2H2 Zn finger	227..247	CDD:275368	6/19 (32%)
		zf-H2C2_2	240..264	CDD:290200	9/23 (39%)
		C2H2 Zn finger	255..275	CDD:275368	6/19 (32%)
		C2H2 Zn finger	283..303	CDD:275368	6/19 (32%)
		zf-H2C2_2	296..319	CDD:290200	9/22 (41%)
		C2H2 Zn finger	311..331	CDD:275368	7/19 (37%)
		zf-H2C2_2	323..348	CDD:290200	11/24 (46%)
		C2H2 Zn finger	339..359	CDD:275368	7/19 (37%)
		zf-H2C2_2	352..375	CDD:290200	12/22 (55%)
		C2H2 Zn finger	367..387	CDD:275368	6/19 (32%)
		C2H2 Zn finger	395..415	CDD:275368	6/19 (32%)
		zf-H2C2_2	408..431	CDD:290200	10/22 (45%)
		C2H2 Zn finger	423..443	CDD:275368	8/19 (42%)
		zf-H2C2_2	435..459	CDD:290200	12/23 (52%)
		C2H2 Zn finger	451..471	CDD:275368	8/19 (42%)
		C2H2 Zn finger	479..499	CDD:275368	6/20 (30%)
		zf-H2C2_2	492..515	CDD:290200	10/23 (43%)
		C2H2 Zn finger	507..527	CDD:275368	8/19 (42%)
		zf-H2C2_2	520..544	CDD:290200	11/27 (41%)
		C2H2 Zn finger	535..555	CDD:275368	8/19 (42%)
		zf-H2C2_2	547..572	CDD:290200	13/24 (54%)
		C2H2 Zn finger	563..583	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	499	1.000	Inparanoid score	I1378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.950