DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZNF383

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_001332876.1	Gene:	ZNF383 / 163087	HGNCID:	18609	Length:	475	Species:	Homo sapiens

Alignment Length:	352	Identity:	133/352 - (37%)
Similarity:	194/352 - (55%)	Gaps:	5/352 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   317 KEHLDNHF---RSHTGETPFRCQYCAKTFTRKEHMVNHVRKHTGETPHRCDICKKSFTRKEHYVN 378
            :.||....   ..|..:..|..:| ..||.::..:..|...:..:.|:.|..|.|:|::...::.
Human   124 RSHLAKQLGYPNGHFSQEIFTPEY-MPTFIQQTFLTLHQIINNEDRPYECKKCGKAFSQNSQFIQ 187

  Fly   379 HYMWHTGQTPHQCDVCGKKYTRKEHLANHMRSHTNETPFRCEICGKSFSRKEHFTNHILWHTGET 443
            |...|.|:..::|..|||.::...|:..|::.||.|.||.|:.|||:||...:.:.|...|||:.
Human   188 HQRIHIGEKSYECKECGKFFSCGSHVTRHLKIHTGEKPFECKECGKAFSCSSYLSQHQRIHTGKK 252

  Fly   444 PHRCDFCSKTFTRKEHLLNHVRQHTGESPHRCSYCMKTFTRKEHLVNHIRQHTGETPFKCTYCTK 508
            |:.|..|.|.|:...:|::|.|.||||.|:.|..|.|.||:...|..|.|.||||.|::|..|.|
Human   253 PYECKECGKAFSYCSNLIDHQRIHTGEKPYECKVCGKAFTKSSQLFQHARIHTGEKPYECKECGK 317

  Fly   509 AFTRKDHMVNHVRQHTGESPHKCTYCTKTFTRKEHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLT 573
            |||:...:|.|.|.||||.|::|..|.|.|:....||||.|.|||:.|:.|..|.|.||:...|.
Human   318 AFTQSSKLVQHQRIHTGEKPYECKECGKAFSSGSALTNHQRIHTGEKPYDCKECGKAFTQSSQLR 382

  Fly   574 NHVRLHTGDSPHKCEYCQKTFTRKEHLNNHMRQHSSDNPHCCNVCNKPFTRKEHLINHMSRCHTG 638
            .|.|:|.|:.|.:|..|.|.||:...|..|.|.|:.:.|:.||.|.|.|.:..:|..|: |.|||
Human   383 QHQRIHAGEKPFECLECGKAFTQNSQLFQHQRIHTDEKPYECNECGKAFNKCSNLTRHL-RIHTG 446

  Fly   639 DRPFTCETCGKSFPLKGNLLFHQRSHT 665
            ::|:.|:.|||:|....:|:.||..||
Human   447 EKPYNCKECGKAFSSGSDLIRHQGIHT 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368
		C2H2 Zn finger	251..271	CDD:275368
		C2H2 Zn finger	279..299	CDD:275368
		COG5048	300..723	CDD:227381	133/352 (38%)
		C2H2 Zn finger	307..327	CDD:275368	2/12 (17%)
		C2H2 Zn finger	335..355	CDD:275368	4/19 (21%)
		C2H2 Zn finger	363..383	CDD:275368	5/19 (26%)
		C2H2 Zn finger	391..411	CDD:275368	6/19 (32%)
		C2H2 Zn finger	419..439	CDD:275368	7/19 (37%)
		C2H2 Zn finger	447..467	CDD:275368	7/19 (37%)
		C2H2 Zn finger	475..495	CDD:275368	8/19 (42%)
		C2H2 Zn finger	503..523	CDD:275368	9/19 (47%)
		C2H2 Zn finger	531..551	CDD:275368	9/19 (47%)
		C2H2 Zn finger	559..579	CDD:275368	8/19 (42%)
		C2H2 Zn finger	587..607	CDD:275368	8/19 (42%)
		C2H2 Zn finger	615..636	CDD:275368	8/20 (40%)
		C2H2 Zn finger	644..664	CDD:275368	8/19 (42%)
		C2H2 Zn finger	676..696	CDD:275368
		C2H2 Zn finger	704..722	CDD:275368
ZNF383	NP_001332876.1	KRAB	6..66	CDD:214630
		zf-C2H2	170..192	CDD:395048	5/21 (24%)
		C2H2 Zn finger	172..192	CDD:275368	5/19 (26%)
		zf-H2C2_2	187..209	CDD:404364	7/21 (33%)
		C2H2 Zn finger	200..220	CDD:275368	6/19 (32%)
		zf-H2C2_2	212..237	CDD:404364	12/24 (50%)
		C2H2 Zn finger	228..248	CDD:275368	7/19 (37%)
		COG5048	<231..475	CDD:227381	105/244 (43%)
		C2H2 Zn finger	256..276	CDD:275368	7/19 (37%)
		C2H2 Zn finger	284..304	CDD:275368	8/19 (42%)
		C2H2 Zn finger	312..332	CDD:275368	9/19 (47%)
		C2H2 Zn finger	340..360	CDD:275368	9/19 (47%)
		C2H2 Zn finger	368..388	CDD:275368	8/19 (42%)
		C2H2 Zn finger	396..416	CDD:275368	8/19 (42%)
		C2H2 Zn finger	424..444	CDD:275368	8/20 (40%)
		C2H2 Zn finger	452..472	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000