Protein Alignment crol and ZNF567

DIOPT Version :10

• Sequence 1: NP_477243.1
• Gene: crol / 34592
• FlyBaseID: FBgn0020309
• Length: 962
• Species: Drosophila melanogaster
• Sequence 2: NP_001374688.1
• Gene: ZNF567 / 163081
• HGNCID: 28696
• Length: 670
• Species: Homo sapiens
• Alignment Length: 446
• Identity: 183/446 - (41%)
• Similarity: 258/446 - (57%)
• Gaps: 15/446 - (3%)

  Fly   226 CGKMFQFRYQLIVHRRYHSERKPFMCQVCGQGFTTSQDLTRHGKIHIGGPMFTCIVCFNVFANNT 290
            |.|.|..|..||.|.|.:....|.:       :...:..|...|.|      ||..|...|...:
Human   238 CEKSFLQRGGLITHSRPYKGENPSV-------YNKKRRATNIEKKH------TCNECGKSFCRKS 289

  Fly   291 SLERHMKRHSTDKPFACTICQKTFARKEHLDNHFRSHTGETPFRCQYCAKTFTRKEHMVNHVRKH 355
            .|..|...||.:||:.|..|...|.||.:|.:|.|:||||.||.|..|.|:|..|..:.:|.|.|
Human   290 VLILHQGIHSEEKPYQCHQCGNAFRRKSYLIDHQRTHTGEKPFVCNECGKSFRLKTALTDHQRTH 354

  Fly   356 TGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYTRKEHLANHMRSHTNETPFRCE 420
            |||..:.|..|:.:|..|.|.:.|...|||:.|::|:.|||.:.:|..|:.|.|.||.|.|:.|:
Human   355 TGEKSYECLQCRNAFRLKSHLIRHQRTHTGEKPYECNDCGKSFRQKTTLSLHQRIHTGEKPYICK 419

  Fly   421 ICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRCSYCMKTFTRK 485
            .|||||.:|.:.|.|...||||.|:.|:.|.|:|::|..|..|.:.|..|.|:.||.|.|:|.:|
Human   420 ECGKSFHQKANLTVHQRTHTGEKPYICNECGKSFSQKTTLALHEKTHNEEKPYICSECGKSFRQK 484

  Fly   486 EHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTGESPHKCTYCTKTFTRKEHLTNHVRQ 550
            ..||.|.|.||||..::|.:|.|||..|.::::|.|.||||.|::|..|.|:|::|.:|..|.|.
Human   485 TTLVAHQRTHTGEKSYECPHCGKAFRMKSYLIDHHRTHTGEKPYECNECGKSFSQKTNLNLHQRI 549

  Fly   551 HTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTFTRKEHLNNHMRQHSSDNPHCC 615
            |||:.|:.|:.|.|:|.:|..||.|.::|||...::|..|.|.|:||.:|.:|.|.|:.:.|:.|
Human   550 HTGEKPYVCNECGKSFRQKATLTVHQKIHTGQKSYECPQCGKAFSRKSYLIHHQRTHTGEKPYKC 614

  Fly   616 NVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGKSFPLKGNLLFHQRSHTKGQEME 671
            :.|.|.|.:|.:||.| .|.|||::|:.|..|||||..|.||:.|||:| ||:.:|
Human   615 SECGKCFRQKTNLIVH-QRTHTGEKPYVCNECGKSFSYKRNLIVHQRTH-KGENIE 668

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_477243.1	C2H2 Zn finger	223..243	CDD:275368	8/16 (50%)
		C2H2 Zn finger	251..271	CDD:275368	2/19 (11%)
		C2H2 Zn finger	279..299	CDD:275368	5/19 (26%)
		COG5048	300..723	CDD:227381	164/372 (44%)
		C2H2 Zn finger	307..327	CDD:275368	8/19 (42%)
		C2H2 Zn finger	335..355	CDD:275368	7/19 (37%)
		C2H2 Zn finger	363..383	CDD:275368	6/19 (32%)
		C2H2 Zn finger	391..411	CDD:275368	8/19 (42%)
		C2H2 Zn finger	419..439	CDD:275368	9/19 (47%)
		C2H2 Zn finger	447..467	CDD:275368	7/19 (37%)
		C2H2 Zn finger	475..495	CDD:275368	10/19 (53%)
		C2H2 Zn finger	503..523	CDD:275368	8/19 (42%)
		C2H2 Zn finger	531..551	CDD:275368	8/19 (42%)
		C2H2 Zn finger	559..579	CDD:275368	8/19 (42%)
		C2H2 Zn finger	587..607	CDD:275368	9/19 (47%)
		C2H2 Zn finger	615..636	CDD:275368	9/20 (45%)
		C2H2 Zn finger	644..664	CDD:275368	12/19 (63%)
		C2H2 Zn finger	676..696	CDD:275368
		C2H2 Zn finger	704..722	CDD:275368
ZNF567	NP_001374688.1	KRAB	6..89	CDD:214630
		C2H2 Zn finger	236..255	CDD:275368	8/16 (50%)
		C2H2 Zn finger	278..298	CDD:275368	5/19 (26%)
		COG5048	302..650	CDD:227381	152/348 (44%)
		C2H2 Zn finger	306..326	CDD:275368	8/19 (42%)
		C2H2 Zn finger	334..354	CDD:275368	7/19 (37%)
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		C2H2 Zn finger	390..410	CDD:275368	8/19 (42%)
		C2H2 Zn finger	418..438	CDD:275368	9/19 (47%)
		C2H2 Zn finger	446..466	CDD:275368	7/19 (37%)
		C2H2 Zn finger	474..494	CDD:275368	10/19 (53%)
		C2H2 Zn finger	502..522	CDD:275368	8/19 (42%)
		C2H2 Zn finger	530..550	CDD:275368	8/19 (42%)
		C2H2 Zn finger	558..578	CDD:275368	8/19 (42%)
		C2H2 Zn finger	586..606	CDD:275368	9/19 (47%)
		C2H2 Zn finger	614..634	CDD:275368	9/20 (45%)
		zf-C2H2	640..662	CDD:395048	12/21 (57%)
		C2H2 Zn finger	642..662	CDD:275368	12/19 (63%)