DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment crol and ZNF433

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	XP_011526027.1	Gene:	ZNF433 / 163059	HGNCID:	20811	Length:	684	Species:	Homo sapiens

Alignment Length:	557	Identity:	192/557 - (34%)
Similarity:	269/557 - (48%)	Gaps:	29/557 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   176 TTAGELLMPKMEGGIHGVDGSGNGGNGGGQNVALAPDGTPIATG------------THVCDICGK 228
            ||.|   :...|..::|..||.:    ...|..:..|     ||            .:.|..|.|
Human   108 TTTG---VKSCESSVYGEVGSAH----SSLNRHIRDD-----TGHKAYEYQEYGQKPYKCKYCKK 160

  Fly   229 MFQFRYQLIVHRRYHSERKPFMCQVCGQGFTTSQDLTRHGKIHIGGPMFTCIVCFNVFANNTSLE 293
            .|.....:..|.|.||.||.::|:.||:.|.:..:|.||..:|.|...:.|..|.......:...
Human   161 PFNCLSSVQTHERAHSGRKLYVCEECGKTFISHSNLQRHRIMHRGDGPYKCKFCGKALMFLSLYL 225

  Fly   294 RHMKRHSTDKPFACTICQKTFARKEHLDNHFRSHTGETPFRCQYCAKTFTRKEHMVNHVRKHTGE 358
            .|.:.|:.:||:.|..|.|.|:....|..|.|:||||.|::|..|.|.|.....:..|.|.||||
Human   226 IHKRTHTGEKPYQCKQCGKAFSHSSSLRIHERTHTGEKPYKCNECGKAFHSSTCLHAHKRTHTGE 290

  Fly   359 TPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYTRKEHLANHMRSHTNETPFRCEICG 423
            .|:.|..|.|:|:....:..|...|||:.|::|..|||.:.....:..|.|:|:.:.|:.|:.||
Human   291 KPYECKQCGKAFSSSHSFQIHERTHTGEKPYECKECGKAFKCPSSVRRHERTHSRKKPYECKHCG 355

  Fly   424 KSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRCSYCMKTFTRKEHL 488
            |..|....|.||:..||||..|:|..|.|.|.....|..|.:.||||.|::|:.|.|.|......
Human   356 KVLSYLTSFQNHLGMHTGEISHKCKICGKAFYSPSSLQTHEKTHTGEKPYKCNQCGKAFNSSSSF 420

  Fly   489 VNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTGESPHKCTYCTKTFTRKEHLTNHVRQHTG 553
            ..|.|.||||.|::|..|.|||.....:..|.|.||||.|:.|..|.|.|:.......|.|.|..
Human   421 RYHERTHTGEKPYECKQCGKAFRSASLLQTHGRTHTGEKPYACKECGKPFSNFSFFQIHERMHRE 485

  Fly   554 DSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTFTRKEHLNNHMRQHSSDNPHCCNVC 618
            :.|:.|....|||:.......|.|.|||...::|:.|.::|........|.|.|:.:.|:.|..|
Human   486 EKPYECKGYGKTFSLPSLFHRHERTHTGGKTYECKQCGRSFNCSSSFRYHGRTHTGEKPYECKQC 550

  Fly   619 NKPFTRKEHLINHMSRCHTGDRPFTCETCGKSFPLKGNLLFHQRSHTKGQEMERPFACEKCPKNF 683
            .|.|.....|..| .|.|||::|:.|:.|||:|....:|..|.|:||.    |:|:.|::|.|:|
Human   551 GKAFRSASQLQIH-GRTHTGEKPYECKQCGKAFGSASHLQMHGRTHTG----EKPYECKQCGKSF 610

  Fly   684 ICKGHLVSHMRSHSGEKPHACTLCSKAFVERGNLKRH 720
            .|...|..|.|:|:||||:.|..|.|||....||:||
Human   611 GCASRLQMHGRTHTGEKPYKCKQCGKAFGCPSNLRRH 647

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	6/19 (32%)
		C2H2 Zn finger	251..271	CDD:275368	7/19 (37%)
		C2H2 Zn finger	279..299	CDD:275368	3/19 (16%)
		COG5048	300..723	CDD:227381	158/421 (38%)
		C2H2 Zn finger	307..327	CDD:275368	7/19 (37%)
		C2H2 Zn finger	335..355	CDD:275368	6/19 (32%)
		C2H2 Zn finger	363..383	CDD:275368	5/19 (26%)
		C2H2 Zn finger	391..411	CDD:275368	6/19 (32%)
		C2H2 Zn finger	419..439	CDD:275368	8/19 (42%)
		C2H2 Zn finger	447..467	CDD:275368	6/19 (32%)
		C2H2 Zn finger	475..495	CDD:275368	6/19 (32%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
		C2H2 Zn finger	531..551	CDD:275368	6/19 (32%)
		C2H2 Zn finger	559..579	CDD:275368	6/19 (32%)
		C2H2 Zn finger	587..607	CDD:275368	5/19 (26%)
		C2H2 Zn finger	615..636	CDD:275368	7/20 (35%)
		C2H2 Zn finger	644..664	CDD:275368	8/19 (42%)
		C2H2 Zn finger	676..696	CDD:275368	8/19 (42%)
		C2H2 Zn finger	704..722	CDD:275368	9/17 (53%)
ZNF433	XP_011526027.1	KRAB	18..>60	CDD:214630
		KRAB	18..57	CDD:279668
		C2H2 Zn finger	145..175	CDD:275368	6/29 (21%)
		C2H2 Zn finger	183..203	CDD:275368	7/19 (37%)
		COG5048	208..614	CDD:227381	145/410 (35%)
		C2H2 Zn finger	211..231	CDD:275368	3/19 (16%)
		zf-H2C2_2	227..248	CDD:290200	8/20 (40%)
		C2H2 Zn finger	239..259	CDD:275368	7/19 (37%)
		zf-H2C2_2	251..276	CDD:290200	12/24 (50%)
		C2H2 Zn finger	267..287	CDD:275368	6/19 (32%)
		zf-H2C2_2	283..304	CDD:290200	11/20 (55%)
		C2H2 Zn finger	295..315	CDD:275368	5/19 (26%)
		zf-H2C2_2	307..332	CDD:290200	9/24 (38%)
		C2H2 Zn finger	323..343	CDD:275368	6/19 (32%)
		C2H2 Zn finger	351..371	CDD:275368	8/19 (42%)
		C2H2 Zn finger	379..399	CDD:275368	6/19 (32%)
		zf-H2C2_2	391..416	CDD:290200	11/24 (46%)
		C2H2 Zn finger	407..427	CDD:275368	6/19 (32%)
		zf-H2C2_2	419..444	CDD:290200	12/24 (50%)
		C2H2 Zn finger	435..455	CDD:275368	7/19 (37%)
		C2H2 Zn finger	463..483	CDD:275368	6/19 (32%)
		C2H2 Zn finger	491..511	CDD:275368	6/19 (32%)
		C2H2 Zn finger	519..539	CDD:275368	5/19 (26%)
		C2H2 Zn finger	547..567	CDD:275368	7/20 (35%)
		C2H2 Zn finger	575..595	CDD:275368	8/19 (42%)
		C2H2 Zn finger	603..623	CDD:275368	8/19 (42%)
		C2H2 Zn finger	631..651	CDD:275368	9/17 (53%)
		zf-H2C2_2	643..668	CDD:290200	4/5 (80%)
		C2H2 Zn finger	659..679	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	499	1.000	Inparanoid score	I1378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.860