DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZNF791

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_699189.2	Gene:	ZNF791 / 163049	HGNCID:	26895	Length:	576	Species:	Homo sapiens

Alignment Length:	517	Identity:	190/517 - (36%)
Similarity:	266/517 - (51%)	Gaps:	17/517 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   218 TGTHVCDICGK-----MFQFRYQLIVHRRYHSERKPFMCQVCGQGFTTSQDLTRHGKIHIGGPMF 277
            ||..:|:  ||     ...|...|.|.:: .:..||:.|.:||:.|.....||||.:.|.|..:|
Human    67 TGERLCE--GKEGSQCAENFSPNLSVTKK-TAGVKPYECTICGKAFMRLSSLTRHMRSHTGYELF 128

  Fly   278 ----TCIVCFNVFANNTSLERHMKRHSTDKPFACTICQKTFARKEHLDNHFRSHTGETPFRCQYC 338
                .|..|...|:...|.:||.:.|:.:||:.|..|.|||...:....|.|:|.||.|:.|:.|
Human   129 EKPYKCKECEKAFSYLKSFQRHERSHTGEKPYKCKQCGKTFIYHQPFQRHERTHIGEKPYECKQC 193

  Fly   339 AKTFTRKEHMVNHVRKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYTRKEH 403
            .|..:....:..|.|.||||.|:.|..|.|:|:.......|...|||:.|:.|..|||.:.....
Human   194 GKALSCSSSLRVHERIHTGEKPYECKQCGKAFSCSSSIRVHERTHTGEKPYACKECGKAFISHTS 258

  Fly   404 LANHMRSHTNETPFRCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHT 468
            :..||.:|..:.|::|:.|||:|........|...||||.|::|..|.|.|.....:..|.|.||
Human   259 VLTHMITHNGDRPYKCKECGKAFIFPSFLRVHERIHTGEKPYKCKQCGKAFRCSTSIQIHERIHT 323

  Fly   469 GESPHRCSYCMKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTGESPHKCTY 533
            ||.|::|..|.|:|:.:.....|:|.||||.|:||..|.|||:|..:...|.|.||||.|::|..
Human   324 GEKPYKCKECGKSFSARPAFRVHVRVHTGEKPYKCKECGKAFSRISYFRIHERTHTGEKPYECKK 388

  Fly   534 CTKTFTRKEHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTFTRKE 598
            |.|||.....|..|.|.|||:.|:.|..|.|||...|:...|:..||||.|:||..|.|.|....
Human   389 CGKTFNYPLDLKIHKRNHTGEKPYECKECAKTFISLENFRRHMITHTGDGPYKCRDCGKVFIFPS 453

  Fly   599 HLNNHMRQHSSDNPHCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGKSFPLKGNLLFHQRS 663
            .|..|.|.|:.:.|:.|..|.|.|:...::..| .|.|||::|:.|:.|||:|....:...|.|.
Human   454 ALRTHERTHTGEKPYECKQCGKAFSCSSYIRIH-KRTHTGEKPYECKECGKAFIYPTSFQGHMRM 517

  Fly   664 HTKGQEMERPFACEKCPKNFICKGHLVSHMRSHSGEKPHACTLCSKAFVERGNLKRHMKMNH 725
            ||.    |:|:.|::|.|.|........|.|.|:.|||..|..|.|||....:||:||:|::
Human   518 HTG----EKPYKCKECGKAFSLHSSFQRHTRIHNYEKPLECKQCGKAFSVSTSLKKHMRMHN 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	6/24 (25%)
		C2H2 Zn finger	251..271	CDD:275368	8/19 (42%)
		C2H2 Zn finger	279..299	CDD:275368	6/19 (32%)
		COG5048	300..723	CDD:227381	161/422 (38%)
		C2H2 Zn finger	307..327	CDD:275368	7/19 (37%)
		C2H2 Zn finger	335..355	CDD:275368	5/19 (26%)
		C2H2 Zn finger	363..383	CDD:275368	5/19 (26%)
		C2H2 Zn finger	391..411	CDD:275368	6/19 (32%)
		C2H2 Zn finger	419..439	CDD:275368	6/19 (32%)
		C2H2 Zn finger	447..467	CDD:275368	6/19 (32%)
		C2H2 Zn finger	475..495	CDD:275368	6/19 (32%)
		C2H2 Zn finger	503..523	CDD:275368	8/19 (42%)
		C2H2 Zn finger	531..551	CDD:275368	8/19 (42%)
		C2H2 Zn finger	559..579	CDD:275368	7/19 (37%)
		C2H2 Zn finger	587..607	CDD:275368	7/19 (37%)
		C2H2 Zn finger	615..636	CDD:275368	6/20 (30%)
		C2H2 Zn finger	644..664	CDD:275368	7/19 (37%)
		C2H2 Zn finger	676..696	CDD:275368	6/19 (32%)
		C2H2 Zn finger	704..722	CDD:275368	8/17 (47%)
ZNF791	NP_699189.2	KRAB	3..44	CDD:396083
		COG5048	98..573	CDD:227381	181/479 (38%)
		C2H2 Zn finger	102..122	CDD:275368	8/19 (42%)
		C2H2 Zn finger	134..154	CDD:275368	6/19 (32%)
		C2H2 Zn finger	162..182	CDD:275368	7/19 (37%)
		C2H2 Zn finger	190..210	CDD:275368	5/19 (26%)
		C2H2 Zn finger	218..238	CDD:275368	5/19 (26%)
		C2H2 Zn finger	246..266	CDD:275368	6/19 (32%)
		C2H2 Zn finger	274..294	CDD:275368	6/19 (32%)
		C2H2 Zn finger	302..322	CDD:275368	6/19 (32%)
		C2H2 Zn finger	330..350	CDD:275368	6/19 (32%)
		C2H2 Zn finger	358..378	CDD:275368	8/19 (42%)
		C2H2 Zn finger	386..406	CDD:275368	8/19 (42%)
		C2H2 Zn finger	414..434	CDD:275368	7/19 (37%)
		C2H2 Zn finger	442..462	CDD:275368	7/19 (37%)
		C2H2 Zn finger	470..490	CDD:275368	6/20 (30%)
		C2H2 Zn finger	498..518	CDD:275368	7/19 (37%)
		C2H2 Zn finger	526..546	CDD:275368	6/19 (32%)
		C2H2 Zn finger	554..574	CDD:275368	9/19 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	499	1.000	Inparanoid score	I1378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.860