DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZNF600

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_001308795.1	Gene:	ZNF600 / 162966	HGNCID:	30951	Length:	791	Species:	Homo sapiens

Alignment Length:	498	Identity:	194/498 - (38%)
Similarity:	283/498 - (56%)	Gaps:	5/498 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   223 CDICGKMFQFRYQLIVHRRYHSERKPFMCQVCGQGFTTSQDLTRHGKIHIGGPMFTCIVCFNVFA 287
            ||:|||:|..:..|..|.|.|:..||:.|..||:.|:....||.|.::|.......|..|..:|.
Human   261 CDVCGKLFNHKQYLTCHCRCHTGEKPYKCNECGKSFSQVSSLTCHRRLHTAVKSHKCNECGKIFG 325

  Fly   288 NNTSLERHMKRHSTDKPFACTICQKTFARKEHLDNHFRSHTGETPFRCQYCAKTFTRKEHMVNHV 352
            .|::|..|...|:.:||:.|..|.|.|.::.:|..|.|.||||.|::|:.|.|.|:||..:.:|.
Human   326 QNSALVIHKAIHTGEKPYKCNECDKAFNQQSNLARHRRIHTGEKPYKCEECDKVFSRKSTLESHK 390

  Fly   353 RKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYTRKEHLANHMRSHTNETPF 417
            |.||||.|::|.:|..:||.......|...|||:..::|:.|||.::.|..|..|.|.|..|..:
Human   391 RIHTGEKPYKCKVCDTAFTWNSQLARHKRIHTGEKTYKCNECGKTFSHKSSLVCHHRLHGGEKSY 455

  Fly   418 RCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRCSYCMKTF 482
            :|::|.|:|:...|...|...|:|..|::|:.|.|||.:...||.|...||||.|::...|.|.|
Human   456 KCKVCDKAFAWNSHLVRHTRIHSGGKPYKCNECGKTFGQNSDLLIHKSIHTGEQPYKYEECEKVF 520

  Fly   483 TRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTGESPHKCTYCTKTFTRKEHLTNH 547
            :....|..|...||||.|:||..|.|||....::..|.|.|:||.|:||..|:|||..:.:|.:|
Human   521 SCGSTLETHKIIHTGEKPYKCKVCDKAFACHSYLAKHTRIHSGEKPYKCNECSKTFRLRSYLASH 585

  Fly   548 VRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTFTRKEHLNNHMRQHSSDNP 612
            .|.|:|:.|::|:.|.|||:::.:|..|.|||:|:.|:||..|.|||:.|..|.:|.|.|:.:..
Human   586 RRVHSGEKPYKCNECSKTFSQRSYLHCHRRLHSGEKPYKCNECGKTFSHKPSLVHHRRLHTGEKS 650

  Fly   613 HCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGKSFPLKGNLLFHQRSHTKGQEMERPFACE 677
            :.|.||:|.|.|..:|..| :|.||.::|:.|..|||:|..:..|..|.|.|..    |:.:.||
Human   651 YKCTVCDKAFVRNSYLARH-TRIHTAEKPYKCNECGKAFNQQSQLSLHHRIHAG----EKLYKCE 710

  Fly   678 KCPKNFICKGHLVSHMRSHSGEKPHACTLCSKAFVERGNLKRH 720
            .|.|.|..|.||..|.|.|.|:||:.|.:|.|.|....:||:|
Human   711 TCDKVFSRKSHLKRHRRIHPGKKPYKCKVCDKTFGSDSHLKQH 753

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	9/19 (47%)
		C2H2 Zn finger	251..271	CDD:275368	7/19 (37%)
		C2H2 Zn finger	279..299	CDD:275368	6/19 (32%)
		COG5048	300..723	CDD:227381	167/421 (40%)
		C2H2 Zn finger	307..327	CDD:275368	7/19 (37%)
		C2H2 Zn finger	335..355	CDD:275368	8/19 (42%)
		C2H2 Zn finger	363..383	CDD:275368	5/19 (26%)
		C2H2 Zn finger	391..411	CDD:275368	8/19 (42%)
		C2H2 Zn finger	419..439	CDD:275368	6/19 (32%)
		C2H2 Zn finger	447..467	CDD:275368	8/19 (42%)
		C2H2 Zn finger	475..495	CDD:275368	5/19 (26%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
		C2H2 Zn finger	531..551	CDD:275368	8/19 (42%)
		C2H2 Zn finger	559..579	CDD:275368	8/19 (42%)
		C2H2 Zn finger	587..607	CDD:275368	9/19 (47%)
		C2H2 Zn finger	615..636	CDD:275368	9/20 (45%)
		C2H2 Zn finger	644..664	CDD:275368	8/19 (42%)
		C2H2 Zn finger	676..696	CDD:275368	10/19 (53%)
		C2H2 Zn finger	704..722	CDD:275368	7/17 (41%)
ZNF600	NP_001308795.1	KRAB	24..71	CDD:214630
		KRAB	24..60	CDD:279668
		COG5048	<154..503	CDD:227381	89/241 (37%)
		C2H2 Zn finger	233..253	CDD:275368
		C2H2 Zn finger	261..281	CDD:275368	9/19 (47%)
		zf-H2C2_2	273..298	CDD:290200	10/24 (42%)
		C2H2 Zn finger	289..309	CDD:275368	7/19 (37%)
		C2H2 Zn finger	317..337	CDD:275368	6/19 (32%)
		zf-H2C2_2	329..354	CDD:290200	9/24 (38%)
		COG5048	341..748	CDD:227381	164/411 (40%)
		C2H2 Zn finger	345..365	CDD:275368	7/19 (37%)
		zf-H2C2_2	357..382	CDD:290200	12/24 (50%)
		C2H2 Zn finger	373..393	CDD:275368	8/19 (42%)
		zf-H2C2_2	386..409	CDD:290200	9/22 (41%)
		C2H2 Zn finger	401..421	CDD:275368	5/19 (26%)
		zf-H2C2_2	414..438	CDD:290200	8/23 (35%)
		C2H2 Zn finger	429..449	CDD:275368	8/19 (42%)
		C2H2 Zn finger	457..477	CDD:275368	6/19 (32%)
		C2H2 Zn finger	485..505	CDD:275368	8/19 (42%)
		C2H2 Zn finger	513..533	CDD:275368	5/19 (26%)
		zf-H2C2_2	526..550	CDD:290200	13/23 (57%)
		C2H2 Zn finger	541..561	CDD:275368	7/19 (37%)
		C2H2 Zn finger	569..589	CDD:275368	8/19 (42%)
		zf-H2C2_2	581..606	CDD:290200	11/24 (46%)
		C2H2 Zn finger	597..617	CDD:275368	8/19 (42%)
		C2H2 Zn finger	625..645	CDD:275368	9/19 (47%)
		C2H2 Zn finger	653..673	CDD:275368	9/20 (45%)
		zf-H2C2_2	665..690	CDD:290200	11/25 (44%)
		C2H2 Zn finger	681..701	CDD:275368	8/19 (42%)
		zf-C2H2	707..729	CDD:278523	10/21 (48%)
		C2H2 Zn finger	709..729	CDD:275368	10/19 (53%)
		zf-H2C2_2	721..744	CDD:290200	11/22 (50%)
		C2H2 Zn finger	737..757	CDD:275368	7/17 (41%)
		zf-H2C2_2	749..773	CDD:290200	3/5 (60%)
		C2H2 Zn finger	765..785	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	47	1.000	Domainoid score	I11996
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	499	1.000	Inparanoid score	I1378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.860