DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZNF483

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_597721.2	Gene:	ZNF483 / 158399	HGNCID:	23384	Length:	744	Species:	Homo sapiens

Alignment Length:	496	Identity:	166/496 - (33%)
Similarity:	240/496 - (48%)	Gaps:	56/496 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   197 GNGGNGGG---QNVALA---------PDGTPIATGTHVCDICGKMFQFRYQLIVH---------R 240
            ||.||..|   ||..|.         ||.:|.          |..|:....||.|         |
Human   276 GNQGNSKGRVAQNKTLGSGSRGKKFDPDKSPF----------GHNFKETSDLIKHLRVYLRKKSR 330

  Fly   241 RYHSERKPFMCQ---VCGQGFTTSQDLTRHGKIHIGGPMFTCIVCFNVFANNTSLERHMKR---H 299
            ||:..:|||...   |..:...|:.:.:|  |.:.||         .|.:::::|..|.||   |
Human   331 RYNESKKPFSFHSDLVLNRKEKTAGEKSR--KSNDGG---------KVLSHSSALTEHQKRQKIH 384

  Fly   300 STDKPFACTICQKTFARKEHLDNHFRSHTGETPFRCQYCAKTFTRKEHMVNHVRKHTGETPHRCD 364
            ..|:...|:.|...|.|:..|...      :||. |:.|.|...::..:.......:||..|:|.
Human   385 LGDRSQKCSKCGIIFIRRSTLSRR------KTPM-CEKCRKDSCQEAALNKDEGNESGEKTHKCS 442

  Fly   365 ICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYTRKEHLANHMRSHTNETPFRCEICGKSFSRK 429
            .|.|:|........|...|||:.|:.|:.|||.::....|..|.|:|:.|.||:|:.|||.|:..
Human   443 KCGKAFGYSASLTKHRRIHTGEKPYMCNECGKAFSDSSSLTPHHRTHSGEKPFKCDDCGKGFTLS 507

  Fly   430 EHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRCSYCMKTFTRKEHLVNHIRQ 494
            .|...|...||||.|::|..|.:.|:....|:.|.|.||||.|:.||.|.|:|:....|..|.|.
Human   508 AHLIKHQRIHTGEKPYKCKDCGRPFSDSSSLIQHQRIHTGEKPYTCSNCGKSFSHSSSLSKHQRI 572

  Fly   495 HTGETPFKCTYCTKAFTRKDHMVNHVRQHTGESPHKCTYCTKTFTRKEHLTNHVRQHTGDSPHRC 559
            ||||.|:||..|.|||.:...:..|.|.||||.|:.|..|..||:....:..|.|.|:|:.|::|
Human   573 HTGEKPYKCGECGKAFRQNSCLTRHQRIHTGEKPYLCNDCGMTFSHFTSVIYHQRLHSGEKPYKC 637

  Fly   560 SYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTFTRKEHLNNHMRQHSSDNPHCCNVCNKPFTR 624
            :.|:|.|.....|:.|.|:|||..|:||:.|.|:|::...||.|.|.|:.:.|:.||.|...|:|
Human   638 NQCEKAFPTHSLLSRHQRIHTGVKPYKCKECGKSFSQSSSLNEHHRIHTGEKPYECNYCGATFSR 702

  Fly   625 KEHLINHMSRCHTGDRPFTCETCGKSFPLKGNLLFHQRSHT 665
            ...|:.|: :.|||.|.:.|..|.|:|.....|:.|:..|:
Human   703 SSILVEHL-KIHTGRREYECNECEKTFKSNSGLIRHRGFHS 742

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	7/28 (25%)
		C2H2 Zn finger	251..271	CDD:275368	4/22 (18%)
		C2H2 Zn finger	279..299	CDD:275368	5/22 (23%)
		COG5048	300..723	CDD:227381	132/366 (36%)
		C2H2 Zn finger	307..327	CDD:275368	5/19 (26%)
		C2H2 Zn finger	335..355	CDD:275368	3/19 (16%)
		C2H2 Zn finger	363..383	CDD:275368	5/19 (26%)
		C2H2 Zn finger	391..411	CDD:275368	7/19 (37%)
		C2H2 Zn finger	419..439	CDD:275368	7/19 (37%)
		C2H2 Zn finger	447..467	CDD:275368	6/19 (32%)
		C2H2 Zn finger	475..495	CDD:275368	8/19 (42%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
		C2H2 Zn finger	531..551	CDD:275368	6/19 (32%)
		C2H2 Zn finger	559..579	CDD:275368	7/19 (37%)
		C2H2 Zn finger	587..607	CDD:275368	8/19 (42%)
		C2H2 Zn finger	615..636	CDD:275368	7/20 (35%)
		C2H2 Zn finger	644..664	CDD:275368	6/19 (32%)
		C2H2 Zn finger	676..696	CDD:275368
		C2H2 Zn finger	704..722	CDD:275368
ZNF483	NP_597721.2	SCAN	49..152	CDD:128708
		SCAN	49..136	CDD:280241
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	137..156
		KRAB	171..229	CDD:214630
		KRAB	171..209	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	263..308		11/41 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	350..385		10/45 (22%)
		C2H2 Zn finger	361..384	CDD:275368	7/31 (23%)
		C2H2 Zn finger	413..433	CDD:275368	3/19 (16%)
		COG5048	437..>735	CDD:227381	116/298 (39%)
		C2H2 Zn finger	441..461	CDD:275368	5/19 (26%)
		zf-H2C2_2	453..477	CDD:290200	9/23 (39%)
		C2H2 Zn finger	469..489	CDD:275368	7/19 (37%)
		zf-H2C2_2	485..505	CDD:290200	10/19 (53%)
		C2H2 Zn finger	497..517	CDD:275368	7/19 (37%)
		zf-H2C2_2	509..533	CDD:290200	9/23 (39%)
		zf-C2H2	523..545	CDD:278523	6/21 (29%)
		C2H2 Zn finger	525..545	CDD:275368	6/19 (32%)
		zf-C2H2	579..601	CDD:278523	8/21 (38%)
		C2H2 Zn finger	581..601	CDD:275368	7/19 (37%)
		zf-H2C2_2	594..618	CDD:290200	11/23 (48%)
		C2H2 Zn finger	609..629	CDD:275368	6/19 (32%)
		zf-H2C2_2	625..644	CDD:290200	8/18 (44%)
		C2H2 Zn finger	637..657	CDD:275368	7/19 (37%)
		zf-H2C2_2	650..674	CDD:290200	12/23 (52%)
		C2H2 Zn finger	665..685	CDD:275368	8/19 (42%)
		zf-H2C2_2	677..702	CDD:290200	10/24 (42%)
		C2H2 Zn finger	693..713	CDD:275368	7/20 (35%)
		zf-H2C2_2	706..730	CDD:290200	10/24 (42%)
		C2H2 Zn finger	721..741	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000