DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZNF714

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_872321.2	Gene:	ZNF714 / 148206	HGNCID:	27124	Length:	555	Species:	Homo sapiens

Alignment Length:	465	Identity:	165/465 - (35%)
Similarity:	226/465 - (48%)	Gaps:	36/465 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   235 QLIVHRRYHSERKPFM----------CQVCGQGF-------TTSQDLTRHGKIHIGGPMFTCIVC 282
            |:|:.|....|.:...          |:|..:|:       ||:|           ..:|.|...
Human    69 QVILRRHGKCEHENLQLRKGSANVVECKVYKKGYNELNQCLTTTQ-----------SKIFPCDKY 122

  Fly   283 FNVFANNTSLERHMKRHSTDKPFACTICQKTFARKEHLDNHFRSHTGETPFRCQYCAKTFTRKEH 347
            ..||....:..||..||:.:|||.|..|.::|....||..|.|.|..|..::|:.|.|.|.|...
Human   123 IKVFHKIFNSNRHKTRHTGEKPFKCKKCDESFCMLLHLHQHKRIHIRENSYQCEECDKVFKRFST 187

  Fly   348 MVNHVRKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYTRKEHLANHMRSHT 412
            :..|.|.||||.|.:|:.|.|:|........|.|.|||:.|::|:.|||.:....||..|...||
Human   188 LTRHKRVHTGEKPFKCEECGKAFKHSSTLTTHKMIHTGEKPYRCEECGKAFYHSSHLTTHKVIHT 252

  Fly   413 NETPFRCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRCSY 477
            .|.||:||.|||:|:.....|.|...|..|.|::|:.|.|.|.|..:|..|...|:||..::|..
Human   253 GEKPFKCEECGKAFNHPSALTTHKFIHVKEKPYKCEECDKAFNRFSYLTKHKIIHSGEKSYKCEQ 317

  Fly   478 CMKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTGESPHKCTYCTKTFTRKE 542
            |.|.|.....|..|.|.||||.|:||..|.|||....|:..|...||||.|:||..|.|.|....
Human   318 CGKGFNWSSTLTKHKRIHTGEKPYKCEECGKAFNVSSHLTTHKMIHTGEKPYKCEECGKAFNHSS 382

  Fly   543 HLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTFTRKEHLNNHMRQH 607
            .||.|...|||:.|::|..|.|.|.:..:||.|..:|||:..:|||.|.|.|.|..:|..|.|.|
Human   383 KLTIHKIIHTGEKPYKCEECGKAFNQSSNLTKHKIIHTGEKLYKCEECGKAFNRSSNLTTHKRIH 447

  Fly   608 SSDNPHCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGKSFPLKGNLLFHQRSHTKGQEMER 672
            :.:.|:.|..|.|.|.|..:|..| :..|||::.:.||.|||:|.....|       ||.:::::
Human   448 TGEKPYKCEECGKAFNRSSNLTKH-NIIHTGEKSYKCEECGKAFNQSSTL-------TKHRKIQQ 504

  Fly   673 PFACEKCPKN 682
            ......|..|
Human   505 GMVAHACNPN 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	3/7 (43%)
		C2H2 Zn finger	251..271	CDD:275368	6/26 (23%)
		C2H2 Zn finger	279..299	CDD:275368	5/19 (26%)
		COG5048	300..723	CDD:227381	147/383 (38%)
		C2H2 Zn finger	307..327	CDD:275368	7/19 (37%)
		C2H2 Zn finger	335..355	CDD:275368	7/19 (37%)
		C2H2 Zn finger	363..383	CDD:275368	6/19 (32%)
		C2H2 Zn finger	391..411	CDD:275368	7/19 (37%)
		C2H2 Zn finger	419..439	CDD:275368	8/19 (42%)
		C2H2 Zn finger	447..467	CDD:275368	7/19 (37%)
		C2H2 Zn finger	475..495	CDD:275368	7/19 (37%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
		C2H2 Zn finger	531..551	CDD:275368	7/19 (37%)
		C2H2 Zn finger	559..579	CDD:275368	7/19 (37%)
		C2H2 Zn finger	587..607	CDD:275368	9/19 (47%)
		C2H2 Zn finger	615..636	CDD:275368	7/20 (35%)
		C2H2 Zn finger	644..664	CDD:275368	7/19 (37%)
		C2H2 Zn finger	676..696	CDD:275368	2/7 (29%)
		C2H2 Zn finger	704..722	CDD:275368
ZNF714	NP_872321.2	KRAB	<2..36	CDD:214630
		C2H2 Zn finger	147..167	CDD:275368	7/19 (37%)
		COG5048	171..504	CDD:227381	133/340 (39%)
		C2H2 Zn finger	175..195	CDD:275368	7/19 (37%)
		zf-H2C2_2	188..212	CDD:290200	11/23 (48%)
		C2H2 Zn finger	203..223	CDD:275368	6/19 (32%)
		C2H2 Zn finger	231..251	CDD:275368	7/19 (37%)
		zf-H2C2_2	243..268	CDD:290200	14/24 (58%)
		C2H2 Zn finger	259..279	CDD:275368	8/19 (42%)
		C2H2 Zn finger	287..307	CDD:275368	7/19 (37%)
		C2H2 Zn finger	315..335	CDD:275368	7/19 (37%)
		zf-H2C2_2	328..351	CDD:290200	13/22 (59%)
		C2H2 Zn finger	343..363	CDD:275368	7/19 (37%)
		zf-H2C2_2	355..380	CDD:290200	12/24 (50%)
		C2H2 Zn finger	371..391	CDD:275368	7/19 (37%)
		zf-H2C2_2	384..408	CDD:290200	11/23 (48%)
		C2H2 Zn finger	399..419	CDD:275368	7/19 (37%)
		zf-H2C2_2	411..436	CDD:290200	12/24 (50%)
		C2H2 Zn finger	427..447	CDD:275368	9/19 (47%)
		zf-H2C2_2	439..464	CDD:290200	9/24 (38%)
		C2H2 Zn finger	455..475	CDD:275368	7/20 (35%)
		zf-H2C2_2	467..492	CDD:290200	11/25 (44%)
		C2H2 Zn finger	483..502	CDD:275368	9/25 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810