Protein Alignment crol and ZNF98

DIOPT Version :10

• Sequence 1: NP_477243.1
• Gene: crol / 34592
• FlyBaseID: FBgn0020309
• Length: 962
• Species: Drosophila melanogaster
• Sequence 2: NP_001092096.1
• Gene: ZNF98 / 148198
• HGNCID: 13174
• Length: 572
• Species: Homo sapiens
• Alignment Length: 458
• Identity: 171/458 - (37%)
• Similarity: 249/458 - (54%)
• Gaps: 25/458 - (5%)

  Fly   251 CQV---CGQGF-----TTSQDLTRHGKIHIGGPMFTCIVCFNVFANNTSLERHMKRHSTDKPFAC 307
            |:|   |..|.     ||...:.::.|.         :..|:.|:|:   .||...|:..|.|.|
Human   132 CKVHKECYNGLNQCLTTTQNKIFQYDKY---------VKVFHKFSNS---NRHKIGHTGKKSFKC 184

  Fly   308 TICQKTFARKEHLDNHFRSHTGETPFRCQYCAKTFTRKEHMVNHVRKHTGETPHRCDICKKSFTR 372
            ..|:|:|....||..|.|.|:||.|::|:.|.|.:....::..|.|.|||:.|::|:.|.|:|.|
Human   185 KECEKSFCMLSHLAQHKRIHSGEKPYKCKECGKAYNEASNLSTHKRIHTGKKPYKCEECGKAFNR 249

  Fly   373 KEHYVNHYMWHTGQTPHQCDVCGKKYTRKEHLANHMRSHTNETPFRCEICGKSFSRKEHFTNHIL 437
            ..|...|.:.|||:.|::|:.|||.:.:..:|..|.|.||.|.|::||.||::||:....|.|.:
Human   250 LSHLTTHKIIHTGKKPYKCEECGKAFNQSANLTTHKRIHTGEKPYKCEECGRAFSQSSTLTAHKI 314

  Fly   438 WHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRCSYCMKTFTRKEHLVNHIRQHTGETPFK 502
            .|.||.|::|:.|.|.|::...|..|...||||..::|..|.|.|:|..||..|.|.|:||.|:|
Human   315 IHAGEKPYKCEECGKAFSQSSTLTTHKIIHTGEKFYKCEECGKAFSRLSHLTTHKRIHSGEKPYK 379

  Fly   503 CTYCTKAFTRKDHMVNHVRQHTGESPHKCTYCTKTFTRKEHLTNHVRQHTGDSPHRCSYCKKTFT 567
            |..|.|||.:...:..|.|.|.||..:||..|:|.|:|..|||.|.|.|||:.|::|..|.|.|.
Human   380 CEECGKAFKQSSTLTTHKRIHAGEKFYKCEVCSKAFSRFSHLTTHKRIHTGEKPYKCEECGKAFN 444

  Fly   568 RKEHLTNHVRLHTGDSPHKCEYCQKTFTRKEHLNNHMRQHSSDNPHCCNVCNKPFTRKEHLINHM 632
            ....||.|..:|||:.|:|||.|.|.|.:...|:.|...|:.:.|:.|..|.|.|.:..||..|
Human   445 LSSQLTTHKIIHTGEKPYKCEECGKAFNQSSTLSKHKVIHTGEKPYKCEECGKAFNQSSHLTTH- 508

  Fly   633 SRCHTGDRPFTCETCGKSFPLKGNLLFHQRSHTKGQEMERPFACEKCPKNFICKGHLVSHMRSHS 697
            ...|||::|:.||.|||:|.....|..|:..|| |:::.:|.:|.....| |.|  :..:.|:.:
Human   509 KMIHTGEKPYKCEECGKAFNNSSILNRHKMIHT-GEKLYKPESCNNACDN-IAK--ISKYKRNCA 569

  Fly   698 GEK 700
            |||
Human   570 GEK 572

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_477243.1	C2H2 Zn finger	223..243	CDD:275368
		C2H2 Zn finger	251..271	CDD:275368	7/27 (26%)
		C2H2 Zn finger	279..299	CDD:275368	5/19 (26%)
		COG5048	300..723	CDD:227381	158/401 (39%)
		C2H2 Zn finger	307..327	CDD:275368	8/19 (42%)
		C2H2 Zn finger	335..355	CDD:275368	5/19 (26%)
		C2H2 Zn finger	363..383	CDD:275368	7/19 (37%)
		C2H2 Zn finger	391..411	CDD:275368	7/19 (37%)
		C2H2 Zn finger	419..439	CDD:275368	8/19 (42%)
		C2H2 Zn finger	447..467	CDD:275368	6/19 (32%)
		C2H2 Zn finger	475..495	CDD:275368	9/19 (47%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
		C2H2 Zn finger	531..551	CDD:275368	10/19 (53%)
		C2H2 Zn finger	559..579	CDD:275368	7/19 (37%)
		C2H2 Zn finger	587..607	CDD:275368	7/19 (37%)
		C2H2 Zn finger	615..636	CDD:275368	7/20 (35%)
		C2H2 Zn finger	644..664	CDD:275368	8/19 (42%)
		C2H2 Zn finger	676..696	CDD:275368	5/19 (26%)
		C2H2 Zn finger	704..722	CDD:275368
ZNF98	NP_001092096.1	KRAB	13..73	CDD:214630
		C2H2 Zn finger	184..204	CDD:275368	8/19 (42%)
		zf-H2C2_2	196..220	CDD:463886	11/23 (48%)
		C2H2 Zn finger	212..232	CDD:275368	5/19 (26%)
		COG5048	235..566	CDD:227381	132/335 (39%)
		C2H2 Zn finger	240..260	CDD:275368	7/19 (37%)
		C2H2 Zn finger	268..288	CDD:275368	7/19 (37%)
		C2H2 Zn finger	296..316	CDD:275368	8/19 (42%)
		C2H2 Zn finger	324..344	CDD:275368	6/19 (32%)
		C2H2 Zn finger	352..372	CDD:275368	9/19 (47%)
		C2H2 Zn finger	380..400	CDD:275368	7/19 (37%)
		C2H2 Zn finger	408..428	CDD:275368	10/19 (53%)
		C2H2 Zn finger	436..456	CDD:275368	7/19 (37%)
		C2H2 Zn finger	464..484	CDD:275368	7/19 (37%)
		C2H2 Zn finger	492..512	CDD:275368	7/20 (35%)
		C2H2 Zn finger	520..540	CDD:275368	8/19 (42%)