DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZNF98

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_001092096.1	Gene:	ZNF98 / 148198	HGNCID:	13174	Length:	572	Species:	Homo sapiens

Alignment Length:	458	Identity:	171/458 - (37%)
Similarity:	249/458 - (54%)	Gaps:	25/458 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   251 CQV---CGQGF-----TTSQDLTRHGKIHIGGPMFTCIVCFNVFANNTSLERHMKRHSTDKPFAC 307
            |:|   |..|.     ||...:.::.|.         :..|:.|:|:   .||...|:..|.|.|
Human   132 CKVHKECYNGLNQCLTTTQNKIFQYDKY---------VKVFHKFSNS---NRHKIGHTGKKSFKC 184

  Fly   308 TICQKTFARKEHLDNHFRSHTGETPFRCQYCAKTFTRKEHMVNHVRKHTGETPHRCDICKKSFTR 372
            ..|:|:|....||..|.|.|:||.|::|:.|.|.:....::..|.|.|||:.|::|:.|.|:|.|
Human   185 KECEKSFCMLSHLAQHKRIHSGEKPYKCKECGKAYNEASNLSTHKRIHTGKKPYKCEECGKAFNR 249

  Fly   373 KEHYVNHYMWHTGQTPHQCDVCGKKYTRKEHLANHMRSHTNETPFRCEICGKSFSRKEHFTNHIL 437
            ..|...|.:.|||:.|::|:.|||.:.:..:|..|.|.||.|.|::||.||::||:....|.|.:
Human   250 LSHLTTHKIIHTGKKPYKCEECGKAFNQSANLTTHKRIHTGEKPYKCEECGRAFSQSSTLTAHKI 314

  Fly   438 WHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRCSYCMKTFTRKEHLVNHIRQHTGETPFK 502
            .|.||.|::|:.|.|.|::...|..|...||||..::|..|.|.|:|..||..|.|.|:||.|:|
Human   315 IHAGEKPYKCEECGKAFSQSSTLTTHKIIHTGEKFYKCEECGKAFSRLSHLTTHKRIHSGEKPYK 379

  Fly   503 CTYCTKAFTRKDHMVNHVRQHTGESPHKCTYCTKTFTRKEHLTNHVRQHTGDSPHRCSYCKKTFT 567
            |..|.|||.:...:..|.|.|.||..:||..|:|.|:|..|||.|.|.|||:.|::|..|.|.|.
Human   380 CEECGKAFKQSSTLTTHKRIHAGEKFYKCEVCSKAFSRFSHLTTHKRIHTGEKPYKCEECGKAFN 444

  Fly   568 RKEHLTNHVRLHTGDSPHKCEYCQKTFTRKEHLNNHMRQHSSDNPHCCNVCNKPFTRKEHLINHM 632
            ....||.|..:|||:.|:|||.|.|.|.:...|:.|...|:.:.|:.|..|.|.|.:..||..|
Human   445 LSSQLTTHKIIHTGEKPYKCEECGKAFNQSSTLSKHKVIHTGEKPYKCEECGKAFNQSSHLTTH- 508

  Fly   633 SRCHTGDRPFTCETCGKSFPLKGNLLFHQRSHTKGQEMERPFACEKCPKNFICKGHLVSHMRSHS 697
            ...|||::|:.||.|||:|.....|..|:..|| |:::.:|.:|.....| |.|  :..:.|:.:
Human   509 KMIHTGEKPYKCEECGKAFNNSSILNRHKMIHT-GEKLYKPESCNNACDN-IAK--ISKYKRNCA 569

  Fly   698 GEK 700
            |||
Human   570 GEK 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368
		C2H2 Zn finger	251..271	CDD:275368	7/27 (26%)
		C2H2 Zn finger	279..299	CDD:275368	5/19 (26%)
		COG5048	300..723	CDD:227381	158/401 (39%)
		C2H2 Zn finger	307..327	CDD:275368	8/19 (42%)
		C2H2 Zn finger	335..355	CDD:275368	5/19 (26%)
		C2H2 Zn finger	363..383	CDD:275368	7/19 (37%)
		C2H2 Zn finger	391..411	CDD:275368	7/19 (37%)
		C2H2 Zn finger	419..439	CDD:275368	8/19 (42%)
		C2H2 Zn finger	447..467	CDD:275368	6/19 (32%)
		C2H2 Zn finger	475..495	CDD:275368	9/19 (47%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
		C2H2 Zn finger	531..551	CDD:275368	10/19 (53%)
		C2H2 Zn finger	559..579	CDD:275368	7/19 (37%)
		C2H2 Zn finger	587..607	CDD:275368	7/19 (37%)
		C2H2 Zn finger	615..636	CDD:275368	7/20 (35%)
		C2H2 Zn finger	644..664	CDD:275368	8/19 (42%)
		C2H2 Zn finger	676..696	CDD:275368	5/19 (26%)
		C2H2 Zn finger	704..722	CDD:275368
ZNF98	NP_001092096.1	KRAB	13..73	CDD:214630
		KRAB	13..52	CDD:279668
		COG5048	179..563	CDD:227381	154/388 (40%)
		C2H2 Zn finger	184..204	CDD:275368	8/19 (42%)
		zf-H2C2_2	196..220	CDD:290200	11/23 (48%)
		C2H2 Zn finger	212..232	CDD:275368	5/19 (26%)
		zf-H2C2_2	224..249	CDD:290200	10/24 (42%)
		C2H2 Zn finger	240..260	CDD:275368	7/19 (37%)
		zf-H2C2_2	252..277	CDD:290200	10/24 (42%)
		C2H2 Zn finger	268..288	CDD:275368	7/19 (37%)
		zf-H2C2_2	280..305	CDD:290200	12/24 (50%)
		C2H2 Zn finger	296..316	CDD:275368	8/19 (42%)
		C2H2 Zn finger	324..344	CDD:275368	6/19 (32%)
		zf-H2C2_2	337..361	CDD:290200	10/23 (43%)
		zf-C2H2	350..372	CDD:278523	9/21 (43%)
		C2H2 Zn finger	352..372	CDD:275368	9/19 (47%)
		zf-H2C2_2	364..389	CDD:290200	14/24 (58%)
		C2H2 Zn finger	380..400	CDD:275368	7/19 (37%)
		C2H2 Zn finger	408..428	CDD:275368	10/19 (53%)
		zf-H2C2_2	420..444	CDD:290200	12/23 (52%)
		C2H2 Zn finger	436..456	CDD:275368	7/19 (37%)
		zf-H2C2_2	449..473	CDD:290200	13/23 (57%)
		C2H2 Zn finger	464..484	CDD:275368	7/19 (37%)
		zf-H2C2_2	477..501	CDD:290200	8/23 (35%)
		C2H2 Zn finger	492..512	CDD:275368	7/20 (35%)
		zf-H2C2_2	504..529	CDD:290200	13/25 (52%)
		C2H2 Zn finger	520..540	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810