DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZNF548

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_001166244.1	Gene:	ZNF548 / 147694	HGNCID:	26561	Length:	545	Species:	Homo sapiens

Alignment Length:	510	Identity:	161/510 - (31%)
Similarity:	229/510 - (44%)	Gaps:	46/510 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   188 GGIHGV-DGSGNGGNGGGQNVALAPDGTPIATG--THVCDICGKMFQFRYQLIVHRRYHSERKPF 249
            |..||. |.......|....|:......|..:.  .|..:.||...:....|:.|...|.|:..:
Human    60 GSWHGAEDEEAPSQQGFSVGVSEVTASKPCLSSQKVHPSETCGPPLKDILCLVEHNGIHPEQHIY 124

  Fly   250 MC---------QVCGQGFTTSQD----LTRHGKIHIGGPMFTCIVCFNVFANNTSLERHMKRHST 301
            :|         |..|:..:...|    ..::.::|:...:|||:..:......:.|.:|....|.
Human   125 ICEAELFQHPKQQIGENLSRGDDWIPSFGKNHRVHMAEEIFTCMEGWKDLPATSCLLQHQGPQSE 189

  Fly   302 DKPFACTICQKTFARKEHLDNHFRSHTGETPFRCQYCAKTFTRKEHMVNHVRKHTGETPHRCDIC 366
            .||:..|..::.|            .||:..::|..|.||||.....|.|.:.||||..:.|:.|
Human   190 WKPYRDTEDREAF------------QTGQNDYKCSECGKTFTCSYSFVEHQKIHTGERSYECNKC 242

  Fly   367 KKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYTRKEHLANHMRSHTNETPFRCEICGKSFSRKEH 431
            .|.|....:::.|...||.:..::|..|||.:.....|..|.|.||.|.|:.|..|||.|.....
Human   243 GKFFKYSANFMKHQTVHTSERTYECRECGKSFMYNYRLMRHKRVHTGERPYECNTCGKFFRYSST 307

  Fly   432 FTNHILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRCSYCMKTFTRKEHLVNHIRQHT 496
            |..|...||||.|:.|..|.|.|.....|:.|.|.||||.|::|:.|.|.|.....|:.|.|.||
Human   308 FVRHQRVHTGERPYECRECGKFFMDSSTLIKHQRVHTGERPYKCNDCGKFFRYISTLIRHQRIHT 372

  Fly   497 GETPFKCTYCTKAFTRKDHMVNHVRQHTGESPHKCTYCTKTFTRKEHLTNHVRQHTGDSPHRCSY 561
            ||.|::|:.|.:.|.....:|.|.|.||||.|:||:.|.|:|.....|..|.|.|||:.|:.||.
Human   373 GERPYECSVCGELFRYNSSLVKHWRNHTGERPYKCSECGKSFRYHCRLIRHQRVHTGERPYECSE 437

  Fly   562 CKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTFTRKEHLNNHMRQHSSDNPHCCNVCNKPFTRKE 626
            |.|.|....:|..|.|.|||:.|::|..|.|.|:.|..|..|.:.||.:.|:.|:.|.|.|.||.
Human   438 CGKFFRYNSNLIKHWRNHTGERPYECRECGKAFSHKHILVEHQKIHSGERPYECSECQKAFIRKS 502

  Fly   627 HLINHMSRCHTGDRPFTCETCGKSF---PLKGNLLFHQRSHTKGQEMERPFACEK 678
            ||::| .:.|:.:|.......|.|.   |...|:              |.|..||
Human   503 HLVHH-QKIHSEERLVCSMNVGNSLAKTPTSLNI--------------RDFTMEK 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	4/19 (21%)
		C2H2 Zn finger	251..271	CDD:275368	4/32 (13%)
		C2H2 Zn finger	279..299	CDD:275368	3/19 (16%)
		COG5048	300..723	CDD:227381	137/382 (36%)
		C2H2 Zn finger	307..327	CDD:275368	2/19 (11%)
		C2H2 Zn finger	335..355	CDD:275368	8/19 (42%)
		C2H2 Zn finger	363..383	CDD:275368	5/19 (26%)
		C2H2 Zn finger	391..411	CDD:275368	7/19 (37%)
		C2H2 Zn finger	419..439	CDD:275368	7/19 (37%)
		C2H2 Zn finger	447..467	CDD:275368	7/19 (37%)
		C2H2 Zn finger	475..495	CDD:275368	7/19 (37%)
		C2H2 Zn finger	503..523	CDD:275368	6/19 (32%)
		C2H2 Zn finger	531..551	CDD:275368	7/19 (37%)
		C2H2 Zn finger	559..579	CDD:275368	8/19 (42%)
		C2H2 Zn finger	587..607	CDD:275368	7/19 (37%)
		C2H2 Zn finger	615..636	CDD:275368	9/20 (45%)
		C2H2 Zn finger	644..664	CDD:275368	4/22 (18%)
		C2H2 Zn finger	676..696	CDD:275368	2/3 (67%)
		C2H2 Zn finger	704..722	CDD:275368
ZNF548	NP_001166244.1	KRAB	20..>60	CDD:214630	161/510 (32%)
		KRAB	20..59	CDD:279668
		C2H2 Zn finger	211..231	CDD:275368	8/19 (42%)
		COG5048	<215..311	CDD:227381	34/95 (36%)
		C2H2 Zn finger	239..259	CDD:275368	5/19 (26%)
		C2H2 Zn finger	267..287	CDD:275368	7/19 (37%)
		zf-H2C2_2	280..304	CDD:290200	12/23 (52%)
		COG5048	<292..507	CDD:227381	90/214 (42%)
		C2H2 Zn finger	295..315	CDD:275368	7/19 (37%)
		zf-H2C2_2	310..330	CDD:290200	9/19 (47%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		zf-H2C2_2	336..360	CDD:290200	12/23 (52%)
		C2H2 Zn finger	351..371	CDD:275368	7/19 (37%)
		zf-H2C2_2	364..388	CDD:290200	11/23 (48%)
		C2H2 Zn finger	379..399	CDD:275368	6/19 (32%)
		zf-H2C2_2	391..416	CDD:290200	13/24 (54%)
		C2H2 Zn finger	407..427	CDD:275368	7/19 (37%)
		zf-H2C2_2	420..444	CDD:290200	12/23 (52%)
		C2H2 Zn finger	435..455	CDD:275368	8/19 (42%)
		zf-H2C2_2	447..472	CDD:290200	11/24 (46%)
		C2H2 Zn finger	463..483	CDD:275368	7/19 (37%)
		C2H2 Zn finger	491..511	CDD:275368	9/20 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000