DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZNF417

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	XP_011524775.1	Gene:	ZNF417 / 147687	HGNCID:	20646	Length:	643	Species:	Homo sapiens

Alignment Length:	493	Identity:	181/493 - (36%)
Similarity:	254/493 - (51%)	Gaps:	31/493 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   221 HVCDICGKMFQFRYQLIVHRRYHSERKPFMCQVCGQGFTTSQDLTRHGKIHIGGPMFTCIVCFNV 285
            |.|::||.:.:..:....|:..|.::|......||:....:..|.:|.|.|||...:...|
Human   160 HPCEMCGLILEDVFHFADHQETHHKQKLNRSGACGKNLDDTAYLHQHQKQHIGEKFYRKSV---- 220

  Fly   286 FANNTSLERHMKRHSTDKPF-----------ACTICQKTFARKEHLDNH------FRSHTGETPF 333
              ...|..:..|...:.:||           :..:||:. |..|..|:.      |:.  |:|.:
Human   221 --REASFVKKRKLRVSQEPFVFREFGKDVLPSSGLCQEA-AAVEKTDSETMHGPPFQE--GKTNY 280

  Fly   334 RCQYCAKTFTRKEHMVNHVRKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKY 398
            .|....|.|:.|..::.|.:..|.:..:.|..|.|||:|...:.||...||.:.|:.|..|||.|
Human   281 SCGKRTKAFSTKHSVIPHQKLFTRDGCYVCSDCGKSFSRYVSFSNHQRDHTAKGPYDCGECGKSY 345

  Fly   399 TRKEHLANHMRSHTNETPFRCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNH 463
            :||..|..|.|.||.:|.:.||.||||||:|....:|...||||.|:.|....|:|.:|.:|:.|
Human   346 SRKSSLIQHQRVHTGKTAYPCEECGKSFSQKGSLISHQRVHTGERPYECREYGKSFGQKGNLIQH 410

  Fly   464 VRQHTGESPHRCSYCMKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTGESP 528
            .:.||||..:.|..|.|:|.:|...:||.|.||||.|:||..|.|:|.:|.::|.|.|.||||.|
Human   411 QQGHTGERAYHCGECGKSFRQKFCFINHQRVHTGERPYKCGECGKSFGQKGNLVQHQRGHTGERP 475

  Fly   529 HKCTYCTKTFTRKEHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKT 593
            ::|..|.|:|..:.|||.|.|.|||:.|:.|..|.|.|.||.||..|.|:|||:.|:.||.|.|.
Human   476 YECKECGKSFRYRSHLTEHQRLHTGERPYNCRECGKLFNRKYHLLVHERVHTGERPYACEVCGKL 540

  Fly   594 FTRKEHLNNHMRQHSSDNPHCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGKSFPLKGNLL 658
            |..|..:..|.|.|:.:.|:.||.|.|.|.....|..| .|.|:|.:|:.|..|||||....:|:
Human   541 FGNKNCVTIHQRIHTGERPYECNECGKSFLSSSALHVH-KRVHSGQKPYKCSECGKSFAECSSLI 604

  Fly   659 FHQRSHTKGQEMERPFACEKCPKNFICKGHLVSHMRSH 696
            .|:|.||.    |||:.|.||.|.|.....|:.|..||
Human   605 KHRRIHTG----ERPYECTKCGKTFQRSSTLLHHQSSH 638

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	4/19 (21%)
		C2H2 Zn finger	251..271	CDD:275368	5/19 (26%)
		C2H2 Zn finger	279..299	CDD:275368	3/19 (16%)
		COG5048	300..723	CDD:227381	163/414 (39%)
		C2H2 Zn finger	307..327	CDD:275368	6/25 (24%)
		C2H2 Zn finger	335..355	CDD:275368	5/19 (26%)
		C2H2 Zn finger	363..383	CDD:275368	8/19 (42%)
		C2H2 Zn finger	391..411	CDD:275368	10/19 (53%)
		C2H2 Zn finger	419..439	CDD:275368	10/19 (53%)
		C2H2 Zn finger	447..467	CDD:275368	6/19 (32%)
		C2H2 Zn finger	475..495	CDD:275368	8/19 (42%)
		C2H2 Zn finger	503..523	CDD:275368	8/19 (42%)
		C2H2 Zn finger	531..551	CDD:275368	9/19 (47%)
		C2H2 Zn finger	559..579	CDD:275368	10/19 (53%)
		C2H2 Zn finger	587..607	CDD:275368	8/19 (42%)
		C2H2 Zn finger	615..636	CDD:275368	8/20 (40%)
		C2H2 Zn finger	644..664	CDD:275368	9/19 (47%)
		C2H2 Zn finger	676..696	CDD:275368	7/19 (37%)
		C2H2 Zn finger	704..722	CDD:275368
ZNF417	XP_011524775.1	KRAB	83..138	CDD:214630
		KRAB	83..122	CDD:279668
		C2H2 Zn finger	162..182	CDD:275368	4/19 (21%)
		C2H2 Zn finger	190..210	CDD:275368	5/19 (26%)
		C2H2 Zn finger	282..302	CDD:275368	5/19 (26%)
		C2H2 Zn finger	310..330	CDD:275368	8/19 (42%)
		C2H2 Zn finger	338..358	CDD:275368	10/19 (53%)
		COG5048	<341..636	CDD:227381	133/299 (44%)
		zf-C2H2	364..386	CDD:278523	10/21 (48%)
		C2H2 Zn finger	366..386	CDD:275368	10/19 (53%)
		C2H2 Zn finger	394..411	CDD:275368	5/16 (31%)
		C2H2 Zn finger	422..442	CDD:275368	8/19 (42%)
		zf-H2C2_2	437..457	CDD:290200	12/19 (63%)
		C2H2 Zn finger	450..470	CDD:275368	8/19 (42%)
		zf-H2C2_2	462..487	CDD:290200	12/24 (50%)
		C2H2 Zn finger	478..498	CDD:275368	9/19 (47%)
		zf-H2C2_2	490..515	CDD:290200	13/24 (54%)
		C2H2 Zn finger	506..526	CDD:275368	10/19 (53%)
		zf-H2C2_2	518..541	CDD:290200	12/22 (55%)
		C2H2 Zn finger	534..554	CDD:275368	8/19 (42%)
		zf-H2C2_2	550..571	CDD:290200	9/20 (45%)
		C2H2 Zn finger	562..582	CDD:275368	8/20 (40%)
		zf-H2C2_2	577..598	CDD:290200	10/21 (48%)
		C2H2 Zn finger	590..610	CDD:275368	9/19 (47%)
		zf-H2C2_2	602..625	CDD:290200	12/26 (46%)
		C2H2 Zn finger	618..638	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810