DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZSCAN29

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_001359009.1	Gene:	ZSCAN29 / 146050	HGNCID:	26673	Length:	852	Species:	Homo sapiens

Alignment Length:	197	Identity:	79/197 - (40%)
Similarity:	109/197 - (55%)	Gaps:	1/197 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly   302 DKPFACTICQKTFARKEHLDNHFRSHTGETPFRCQYCAKTFTRKEHMVNHVRKHTGETPHRCDIC 366
            ::|:......|:|.....| .|..||..|.|::|..|.|:|:|...::.|.|.||||.|::|..|
Human   648 ERPYKYLKYSKSFGPNSLL-MHQVSHQVENPYKCADCGKSFSRSARLIRHRRIHTGEKPYKCLDC 711

  Fly   367 KKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYTRKEHLANHMRSHTNETPFRCEICGKSFSRKEH 431
            .|||....:::.|...|||:.|:||..|||.:.:...|..|.|:||.|.|::||.|||||:...|
Human   712 GKSFRDSSNFITHRRIHTGEKPYQCGECGKCFNQSSSLIIHQRTHTGEKPYQCEECGKSFNNSSH 776

  Fly   432 FTNHILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRCSYCMKTFTRKEHLVNHIRQHT 496
            |:.|...||||.||.|..|.|:|::...|..|.|.||||.|:.|..|.|.|::...|..|...|.
Human   777 FSAHRRIHTGERPHVCPDCGKSFSKSSDLRAHHRTHTGEKPYGCHDCGKCFSKSSALNKHGEIHA 841

  Fly   497 GE 498
            .|
Human   842 RE 843

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368
		C2H2 Zn finger	251..271	CDD:275368
		C2H2 Zn finger	279..299	CDD:275368
		COG5048	300..723	CDD:227381	79/197 (40%)
		C2H2 Zn finger	307..327	CDD:275368	4/19 (21%)
		C2H2 Zn finger	335..355	CDD:275368	7/19 (37%)
		C2H2 Zn finger	363..383	CDD:275368	6/19 (32%)
		C2H2 Zn finger	391..411	CDD:275368	7/19 (37%)
		C2H2 Zn finger	419..439	CDD:275368	10/19 (53%)
		C2H2 Zn finger	447..467	CDD:275368	7/19 (37%)
		C2H2 Zn finger	475..495	CDD:275368	6/19 (32%)
		C2H2 Zn finger	503..523	CDD:275368
		C2H2 Zn finger	531..551	CDD:275368
		C2H2 Zn finger	559..579	CDD:275368
		C2H2 Zn finger	587..607	CDD:275368
		C2H2 Zn finger	615..636	CDD:275368
		C2H2 Zn finger	644..664	CDD:275368
		C2H2 Zn finger	676..696	CDD:275368
		C2H2 Zn finger	704..722	CDD:275368
ZSCAN29	NP_001359009.1	SCAN	14..124	CDD:128708
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	96..182
		Myb_DNA-bind_4	245..330	CDD:372747
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	347..400
		Myb_DNA-bind_4	408..493	CDD:372747
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	502..557
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	603..625
		COG5048	<630..838	CDD:227381	77/190 (41%)
		C2H2 Zn finger	680..700	CDD:275368	7/19 (37%)
		C2H2 Zn finger	708..728	CDD:275368	6/19 (32%)
		C2H2 Zn finger	736..756	CDD:275368	7/19 (37%)
		C2H2 Zn finger	764..784	CDD:275368	10/19 (53%)
		C2H2 Zn finger	792..812	CDD:275368	7/19 (37%)
		C2H2 Zn finger	820..840	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23226
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100