DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZFP28

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_065879.1	Gene:	ZFP28 / 140612	HGNCID:	17801	Length:	868	Species:	Homo sapiens

Alignment Length:	473	Identity:	188/473 - (39%)
Similarity:	251/473 - (53%)	Gaps:	14/473 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   187 EGGIHGVDGSGNGGNGGGQNVALAPDGTPIATGTHV--CDICGKMFQFRYQLIVHRRYHSERKPF 249
            |..:|..|...|     .|..::....|.|..|..:  |:.|.|.|.....|.||:|.|:..||:
Human   389 EEKVHNRDSIKN-----FQKSSVVIKQTGIYAGKKLFKCNECKKTFTQSSSLTVHQRIHTGEKPY 448

  Fly   250 MCQVCGQGFTTSQDLTRHGKIHIGGPMFTCIVCFNVFANNTSLERHMK-RHSTDKPFACTICQKT 313
            .|..||:.|:......||.:.|.|...:.||.|...|..||||.||.: .|:.:|||.|..|.|.
Human   449 KCNECGKAFSDGSSFARHQRCHTGKKPYECIECGKAFIQNTSLIRHWRYYHTGEKPFDCIDCGKA 513

  Fly   314 FARKEHLDNHFRSHTGETPFRCQYCAKTFTRKEHMVNHVRKHTGETPHRCDICKKSFTRKEHYVN 378
            |:....|:.|.|.||||.|::|..|.|:|.....:..|.|.||||.|:.||:|:|:|:.......
Human   514 FSDHIGLNQHRRIHTGEKPYKCDVCHKSFRYGSSLTVHQRIHTGEKPYECDVCRKAFSHHASLTQ 578

  Fly   379 HYMWHTGQTPHQCDVCGKKYTRKEHLANHMRSHTNETPFRCEICGKSFSRKEHFTNHILWHTGET 443
            |...|:|:.|.:|..|||.:.:..|||:|:|.||.|.||.|..||||||.......|...||||.
Human   579 HQRVHSGEKPFKCKECGKAFRQNIHLASHLRIHTGEKPFECAECGKSFSISSQLATHQRIHTGEK 643

  Fly   444 PHRCDFCSKTFTRKEHLLNHVRQHTGESPHRCSYCMKTFTRKEHLVNHIRQHTGETPFKCTYCTK 508
            |:.|..|||.||:|.||..|.:.||||.|:.|..|.|.|::..||:.|.|.||||.|:||..|.|
Human   644 PYECKVCSKAFTQKAHLAQHQKTHTGEKPYECKECGKAFSQTTHLIQHQRVHTGEKPYKCMECGK 708

  Fly   509 AFTRKDHMVNHVRQHTGESPHKCTYCTKTFTRKEHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLT 573
            ||........|.|.|||:.|::|..|.|.|..|..|..|.|.|||:.|:.||.|.|.|:.::.|:
Human   709 AFGDNSSCTQHQRLHTGQRPYECIECGKAFKTKSSLICHRRSHTGEKPYECSVCGKAFSHRQSLS 773

  Fly   574 NHVRLHTGDSPHKCEYCQKTFTRKEHLNNHMRQHSSDNPHCCNVCNKPFTRKEHLINHMSRCHTG 638
            .|.|:|:|..|::|:.|:|||.:..|||.|.|.|:.:..:......|.|.:..||.:| .|.|||
Human   774 VHQRIHSGKKPYECKECRKTFIQIGHLNQHKRVHTGERSYNYKKSRKVFRQTAHLAHH-QRIHTG 837

  Fly   639 DRPFTCETCGKSFPLKGN 656
            :    ..|| .|.|...|
Human   838 E----SSTC-PSLPSTSN 850

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	8/19 (42%)
		C2H2 Zn finger	251..271	CDD:275368	6/19 (32%)
		C2H2 Zn finger	279..299	CDD:275368	10/20 (50%)
		COG5048	300..723	CDD:227381	150/357 (42%)
		C2H2 Zn finger	307..327	CDD:275368	7/19 (37%)
		C2H2 Zn finger	335..355	CDD:275368	6/19 (32%)
		C2H2 Zn finger	363..383	CDD:275368	6/19 (32%)
		C2H2 Zn finger	391..411	CDD:275368	9/19 (47%)
		C2H2 Zn finger	419..439	CDD:275368	8/19 (42%)
		C2H2 Zn finger	447..467	CDD:275368	10/19 (53%)
		C2H2 Zn finger	475..495	CDD:275368	8/19 (42%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
		C2H2 Zn finger	531..551	CDD:275368	8/19 (42%)
		C2H2 Zn finger	559..579	CDD:275368	8/19 (42%)
		C2H2 Zn finger	587..607	CDD:275368	10/19 (53%)
		C2H2 Zn finger	615..636	CDD:275368	6/20 (30%)
		C2H2 Zn finger	644..664	CDD:275368	5/13 (38%)
		C2H2 Zn finger	676..696	CDD:275368
		C2H2 Zn finger	704..722	CDD:275368
ZFP28	NP_065879.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..82
		KRAB	103..163	CDD:214630
		KRAB	103..142	CDD:279668
		KRAB	232..288	CDD:214630
		KRAB	232..266	CDD:279668
		COG5048	417..806	CDD:227381	164/388 (42%)
		zf-C2H2	420..442	CDD:278523	8/21 (38%)
		C2H2 Zn finger	422..442	CDD:275368	8/19 (42%)
		zf-H2C2_2	434..458	CDD:290200	10/23 (43%)
		C2H2 Zn finger	450..470	CDD:275368	6/19 (32%)
		zf-H2C2_2	462..487	CDD:290200	8/24 (33%)
		C2H2 Zn finger	478..496	CDD:275368	10/17 (59%)
		C2H2 Zn finger	507..527	CDD:275368	7/19 (37%)
		zf-H2C2_2	520..544	CDD:290200	12/23 (52%)
		C2H2 Zn finger	535..555	CDD:275368	6/19 (32%)
		zf-H2C2_2	547..572	CDD:290200	12/24 (50%)
		C2H2 Zn finger	563..583	CDD:275368	6/19 (32%)
		zf-H2C2_2	575..600	CDD:290200	8/24 (33%)
		C2H2 Zn finger	591..611	CDD:275368	9/19 (47%)
		zf-H2C2_2	603..627	CDD:290200	15/23 (65%)
		C2H2 Zn finger	619..639	CDD:275368	8/19 (42%)
		zf-H2C2_2	632..656	CDD:290200	11/23 (48%)
		C2H2 Zn finger	647..667	CDD:275368	10/19 (53%)
		zf-H2C2_2	659..684	CDD:290200	12/24 (50%)
		C2H2 Zn finger	675..695	CDD:275368	8/19 (42%)
		zf-H2C2_2	687..710	CDD:290200	13/22 (59%)
		C2H2 Zn finger	703..723	CDD:275368	7/19 (37%)
		zf-H2C2_2	718..740	CDD:290200	10/21 (48%)
		C2H2 Zn finger	731..751	CDD:275368	8/19 (42%)
		zf-H2C2_2	743..768	CDD:290200	12/24 (50%)
		C2H2 Zn finger	759..779	CDD:275368	8/19 (42%)
		zf-H2C2_2	771..796	CDD:290200	11/24 (46%)
		C2H2 Zn finger	787..807	CDD:275368	10/19 (53%)
		C2H2 Zn finger	815..835	CDD:275368	6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	499	1.000	Inparanoid score	I1378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.950