Protein Alignment crol and ZFP28

DIOPT Version :10

• Sequence 1: NP_477243.1
• Gene: crol / 34592
• FlyBaseID: FBgn0020309
• Length: 962
• Species: Drosophila melanogaster
• Sequence 2: NP_065879.1
• Gene: ZFP28 / 140612
• HGNCID: 17801
• Length: 868
• Species: Homo sapiens
• Alignment Length: 473
• Identity: 188/473 - (39%)
• Similarity: 251/473 - (53%)
• Gaps: 14/473 - (2%)

  Fly   187 EGGIHGVDGSGNGGNGGGQNVALAPDGTPIATGTHV--CDICGKMFQFRYQLIVHRRYHSERKPF 249
            |..:|..|...|     .|..::....|.|..|..:  |:.|.|.|.....|.||:|.|:..||:
Human   389 EEKVHNRDSIKN-----FQKSSVVIKQTGIYAGKKLFKCNECKKTFTQSSSLTVHQRIHTGEKPY 448

  Fly   250 MCQVCGQGFTTSQDLTRHGKIHIGGPMFTCIVCFNVFANNTSLERHMK-RHSTDKPFACTICQKT 313
            .|..||:.|:......||.:.|.|...:.||.|...|..||||.||.: .|:.:|||.|..|.|.
Human   449 KCNECGKAFSDGSSFARHQRCHTGKKPYECIECGKAFIQNTSLIRHWRYYHTGEKPFDCIDCGKA 513

  Fly   314 FARKEHLDNHFRSHTGETPFRCQYCAKTFTRKEHMVNHVRKHTGETPHRCDICKKSFTRKEHYVN 378
            |:....|:.|.|.||||.|::|..|.|:|.....:..|.|.||||.|:.||:|:|:|:.......
Human   514 FSDHIGLNQHRRIHTGEKPYKCDVCHKSFRYGSSLTVHQRIHTGEKPYECDVCRKAFSHHASLTQ 578

  Fly   379 HYMWHTGQTPHQCDVCGKKYTRKEHLANHMRSHTNETPFRCEICGKSFSRKEHFTNHILWHTGET 443
            |...|:|:.|.:|..|||.:.:..|||:|:|.||.|.||.|..||||||.......|...||||.
Human   579 HQRVHSGEKPFKCKECGKAFRQNIHLASHLRIHTGEKPFECAECGKSFSISSQLATHQRIHTGEK 643

  Fly   444 PHRCDFCSKTFTRKEHLLNHVRQHTGESPHRCSYCMKTFTRKEHLVNHIRQHTGETPFKCTYCTK 508
            |:.|..|||.||:|.||..|.:.||||.|:.|..|.|.|::..||:.|.|.||||.|:||..|.|
Human   644 PYECKVCSKAFTQKAHLAQHQKTHTGEKPYECKECGKAFSQTTHLIQHQRVHTGEKPYKCMECGK 708

  Fly   509 AFTRKDHMVNHVRQHTGESPHKCTYCTKTFTRKEHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLT 573
            ||........|.|.|||:.|::|..|.|.|..|..|..|.|.|||:.|:.||.|.|.|:.::.|:
Human   709 AFGDNSSCTQHQRLHTGQRPYECIECGKAFKTKSSLICHRRSHTGEKPYECSVCGKAFSHRQSLS 773

  Fly   574 NHVRLHTGDSPHKCEYCQKTFTRKEHLNNHMRQHSSDNPHCCNVCNKPFTRKEHLINHMSRCHTG 638
            .|.|:|:|..|::|:.|:|||.:..|||.|.|.|:.:..:......|.|.:..||.:| .|.|||
Human   774 VHQRIHSGKKPYECKECRKTFIQIGHLNQHKRVHTGERSYNYKKSRKVFRQTAHLAHH-QRIHTG 837

  Fly   639 DRPFTCETCGKSFPLKGN 656
            :    ..|| .|.|...|
Human   838 E----SSTC-PSLPSTSN 850

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_477243.1	C2H2 Zn finger	223..243	CDD:275368	8/19 (42%)
		C2H2 Zn finger	251..271	CDD:275368	6/19 (32%)
		C2H2 Zn finger	279..299	CDD:275368	10/20 (50%)
		COG5048	300..723	CDD:227381	150/357 (42%)
		C2H2 Zn finger	307..327	CDD:275368	7/19 (37%)
		C2H2 Zn finger	335..355	CDD:275368	6/19 (32%)
		C2H2 Zn finger	363..383	CDD:275368	6/19 (32%)
		C2H2 Zn finger	391..411	CDD:275368	9/19 (47%)
		C2H2 Zn finger	419..439	CDD:275368	8/19 (42%)
		C2H2 Zn finger	447..467	CDD:275368	10/19 (53%)
		C2H2 Zn finger	475..495	CDD:275368	8/19 (42%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
		C2H2 Zn finger	531..551	CDD:275368	8/19 (42%)
		C2H2 Zn finger	559..579	CDD:275368	8/19 (42%)
		C2H2 Zn finger	587..607	CDD:275368	10/19 (53%)
		C2H2 Zn finger	615..636	CDD:275368	6/20 (30%)
		C2H2 Zn finger	644..664	CDD:275368	5/13 (38%)
		C2H2 Zn finger	676..696	CDD:275368
		C2H2 Zn finger	704..722	CDD:275368
ZFP28	NP_065879.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..82
		KRAB	103..163	CDD:214630
		KRAB	232..288	CDD:214630
		COG5048	417..806	CDD:227381	164/388 (42%)
		C2H2 Zn finger	422..442	CDD:275368	8/19 (42%)
		C2H2 Zn finger	450..470	CDD:275368	6/19 (32%)
		C2H2 Zn finger	478..496	CDD:275368	10/17 (59%)
		C2H2 Zn finger	507..527	CDD:275368	7/19 (37%)
		C2H2 Zn finger	535..555	CDD:275368	6/19 (32%)
		C2H2 Zn finger	563..583	CDD:275368	6/19 (32%)
		C2H2 Zn finger	591..611	CDD:275368	9/19 (47%)
		C2H2 Zn finger	619..639	CDD:275368	8/19 (42%)
		C2H2 Zn finger	647..667	CDD:275368	10/19 (53%)
		C2H2 Zn finger	675..695	CDD:275368	8/19 (42%)
		C2H2 Zn finger	703..723	CDD:275368	7/19 (37%)
		C2H2 Zn finger	731..751	CDD:275368	8/19 (42%)
		C2H2 Zn finger	759..779	CDD:275368	8/19 (42%)
		C2H2 Zn finger	787..807	CDD:275368	10/19 (53%)
		C2H2 Zn finger	815..835	CDD:275368	6/20 (30%)