DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZNF573

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_001166161.1	Gene:	ZNF573 / 126231	HGNCID:	26420	Length:	665	Species:	Homo sapiens

Alignment Length:	530	Identity:	192/530 - (36%)
Similarity:	272/530 - (51%)	Gaps:	33/530 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   223 CDICGKMFQFRYQLIVHRRYHSERKPFMCQVCGQGFTTSQDLTRHGKIHIGGPMFTCIVCFNVFA 287
            |..|.|.|...||||:|.|:|...:|:.|:.||:.|.:...||.|.:.|.|...:.|..|...|.
Human   136 CKKCQKKFSSGYQLILHHRFHVIERPYECKECGKNFRSGYQLTLHQRFHTGEKPYECTECGKNFR 200

  Fly   288 NNTSLERHMKRHSTDKPFACTICQKTFARKEHLDNHFRSHTGETPFRCQYCAKTFTRKEHMVNHV 352
            :...|..|.:.|:.:|.:.|..|.|.|....|:..|.|.|||..|:.||.|.:.|::..|:..|.
Human   201 SGYQLTVHQRFHTGEKTYECRQCGKAFIYASHIVQHERIHTGGKPYECQECGRAFSQGGHLRIHQ 265

  Fly   353 RKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYTRKEHLANHMRSHTNETPF 417
            |.||||.|::|..|.|:|:|:.:.|.|..:||.:.|:.|:.|||.:.|...|..|.|.||.:.|:
Human   266 RVHTGEKPYKCKECGKTFSRRSNLVEHGQFHTDEKPYICEKCGKAFRRGHQLTVHQRVHTGKKPY 330

  Fly   418 RCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRCSYCMKTF 482
            .|:.|||.::...:|..|...|.|..|:.|..|.||||...:|..|...||||....|..|.||:
Human   331 ECKECGKGYTTASYFLLHQRIHKGGKPYECKECKKTFTLYRNLTRHQNIHTGEKLFECKQCGKTY 395

  Fly   483 TRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTGESPHKCTYCTKTFTRKEHLTNH 547
            |....|..|.:.||||.|::|..|.|||:...::..|.:.|||....:|..|.||||...:||.|
Human   396 TTGSKLFQHQKTHTGEKPYECKECGKAFSLYGYLKQHQKIHTGMKHFECKECKKTFTLYRNLTRH 460

  Fly   548 V----------------------------RQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSP 584
            .                            :.|||:.|::|..|.|||:...:|..|.::|||..|
Human   461 QNIHTGKKLFECQECGKAYSTGSNLIQHRKTHTGEKPYKCKECGKTFSLHGYLNQHQKIHTGMKP 525

  Fly   585 HKCEYCQKTFTRKEHLNNHMRQHSSDNPHCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGK 649
            ::|:.|:||||...:|..|...|:.:.|..|..|.|.|.|..||..|.| .|...:|:.|:.|||
Human   526 YECKVCRKTFTFYRNLTLHQSIHTDEKPFECKECGKTFRRSSHLTAHQS-IHADKKPYECKECGK 589

  Fly   650 SFPLKGNLLFHQRSHTKGQEMERPFACEKCPKNFICKGHLVSHMRSHSGEKPHACTLCSKAFVER 714
            :|.:.|.|..||:.||.|    :|:.|::|.|.|....:||.|.|.|:||||:.|..|.|.|...
Human   590 AFKMYGYLTQHQKIHTGG----KPYECKECGKAFSRASNLVQHERIHTGEKPYVCKQCGKTFRYG 650

  Fly   715 GNLKRHMKMN 724
            ..||.|.:::
Human   651 SALKAHQRIH 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	10/19 (53%)
		C2H2 Zn finger	251..271	CDD:275368	7/19 (37%)
		C2H2 Zn finger	279..299	CDD:275368	5/19 (26%)
		COG5048	300..723	CDD:227381	165/450 (37%)
		C2H2 Zn finger	307..327	CDD:275368	7/19 (37%)
		C2H2 Zn finger	335..355	CDD:275368	7/19 (37%)
		C2H2 Zn finger	363..383	CDD:275368	7/19 (37%)
		C2H2 Zn finger	391..411	CDD:275368	8/19 (42%)
		C2H2 Zn finger	419..439	CDD:275368	6/19 (32%)
		C2H2 Zn finger	447..467	CDD:275368	8/19 (42%)
		C2H2 Zn finger	475..495	CDD:275368	7/19 (37%)
		C2H2 Zn finger	503..523	CDD:275368	6/19 (32%)
		C2H2 Zn finger	531..551	CDD:275368	9/47 (19%)
		C2H2 Zn finger	559..579	CDD:275368	7/19 (37%)
		C2H2 Zn finger	587..607	CDD:275368	8/19 (42%)
		C2H2 Zn finger	615..636	CDD:275368	9/20 (45%)
		C2H2 Zn finger	644..664	CDD:275368	9/19 (47%)
		C2H2 Zn finger	676..696	CDD:275368	8/19 (42%)
		C2H2 Zn finger	704..722	CDD:275368	7/17 (41%)
ZNF573	NP_001166161.1	KRAB	28..89	CDD:214630
		KRAB	28..67	CDD:279668
		C2H2 Zn finger	136..156	CDD:275368	10/19 (53%)
		C2H2 Zn finger	164..184	CDD:275368	7/19 (37%)
		C2H2 Zn finger	192..212	CDD:275368	5/19 (26%)
		C2H2 Zn finger	220..240	CDD:275368	7/19 (37%)
		COG5048	244..628	CDD:227381	140/388 (36%)
		C2H2 Zn finger	248..268	CDD:275368	7/19 (37%)
		zf-H2C2_2	260..285	CDD:290200	12/24 (50%)
		C2H2 Zn finger	276..292	CDD:275368	6/15 (40%)
		C2H2 Zn finger	304..324	CDD:275368	8/19 (42%)
		C2H2 Zn finger	332..352	CDD:275368	6/19 (32%)
		C2H2 Zn finger	360..380	CDD:275368	8/19 (42%)
		C2H2 Zn finger	388..408	CDD:275368	7/19 (37%)
		zf-H2C2_2	401..424	CDD:290200	11/22 (50%)
		C2H2 Zn finger	416..436	CDD:275368	6/19 (32%)
		C2H2 Zn finger	444..464	CDD:275368	9/19 (47%)
		C2H2 Zn finger	472..492	CDD:275368	0/19 (0%)
		zf-H2C2_2	484..508	CDD:290200	8/23 (35%)
		C2H2 Zn finger	500..520	CDD:275368	7/19 (37%)
		zf-H2C2_2	512..536	CDD:290200	10/23 (43%)
		C2H2 Zn finger	528..548	CDD:275368	8/19 (42%)
		C2H2 Zn finger	556..576	CDD:275368	9/20 (45%)
		C2H2 Zn finger	584..604	CDD:275368	9/19 (47%)
		zf-H2C2_2	596..621	CDD:290200	11/28 (39%)
		C2H2 Zn finger	612..632	CDD:275368	8/19 (42%)
		zf-H2C2_2	624..649	CDD:290200	13/24 (54%)
		C2H2 Zn finger	640..660	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	499	1.000	Inparanoid score	I1378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.860