DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZNF440

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	XP_005259788.1	Gene:	ZNF440 / 126070	HGNCID:	20874	Length:	598	Species:	Homo sapiens

Alignment Length:	552	Identity:	149/552 - (26%)
Similarity:	229/552 - (41%)	Gaps:	96/552 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   254 CGQGFTTSQDLTRHGKIHIGGP-MFTC--IVCFNVFANNTSLERHMK----------RHSTDKPF 305
            ||:.||...|...:.:.....| :.:|  .||..|...|:|...:::          :....||.
Human    83 CGETFTPVPDDRLNFQEKKASPEVKSCESFVCGEVGLGNSSFNMNIRGDIGHKAYEYQEYGPKPC 147

  Fly   306 ACTICQKTFARKEHLDNHFRSHTGETPFRCQYCAKTFTRKEHMVNHVRKHTGETPHRCDICKKSF 370
            .|...:|.|..:.......|.||||.|..|:.|.|||.....:..|:..|:|:.|::|..|.|:|
Human   148 KCQQPKKAFRYRPSFRTQERDHTGEKPNACKVCGKTFISHSSVRRHMVMHSGDGPYKCKFCGKAF 212

  Fly   371 TRKEHYVNHYMWHTGQTPHQCDVCGKKYTRKEHLANHMRSHTNETPFRCEICGKSFSRKEHFTNH 435
            .....|:.|...|||:.|.:|..|||.::.......|.|:||.|.|:..:.|||:|.....:..|
Human   213 HCLRLYLIHERIHTGEKPCECKQCGKSFSYSATHRIHKRTHTGEKPYEYQECGKAFHSPRSYRRH 277

  Fly   436 ILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRCSYCMKTFTRKEHLVNHIRQHTGETP 500
            ...|.||..::|..|.|.||...::..|.|.|:.::.:.|..|.|..:.......|:|.|:||.|
Human   278 ERIHMGEKAYQCKECGKAFTCPRYVRIHERTHSRKNLYECKQCGKALSSLTSFQTHVRLHSGERP 342

  Fly   501 FKCTYCTKAFTRKDHMVNHVRQHTGESPHKCTYCTKTFTRKEHLTNHVRQHTGDSPHRCSYCKKT 565
            ::|..|.|.|...:....|.:.|:||.|:||..|.|.|.....|..|.|.|||:.|:.|..|.|.
Human   343 YECKICGKDFCSVNSFQRHEKIHSGEKPYKCKQCGKAFPHSSSLRYHERTHTGEKPYECKQCGKA 407

  Fly   566 FTRKEHLTNHVRLHTGDSPHKCEYCQKTFTRKEHLNNHMRQHSSDNPHCCNVCNKPFTRKEHLIN 630
            |....||..|.|.|||:.|::|:.|.|.|....:|.:|.|..:                  |:
Human   408 FRSASHLRVHGRTHTGEKPYECKECGKAFRYVNNLQSHERTQT------------------HI-- 452

  Fly   631 HMSRCHTGDRPFTCETCGKSFPLKGNLLFHQRSHTKGQEMERPFACEKCPKNFICKGHLVSHMRS 695
               |.|:|:|.:.|:.|||.|                          .|||:|      ..|.::
Human   453 ---RIHSGERRYKCKICGKGF--------------------------YCPKSF------QRHEKT 482

  Fly   696 HSGEKPHAC--------------------TLCSKAFVERGNLKRHMKMNHPDAMMPPPPVHPHPQ 740
            |:|||.:.|                    || .::.:...|:.:..::......|....:..:|.
Human   483 HTGEKLYECKQRSVVPSVVPVPFDIMKGLTL-ERSPINASNVGKPSELCQSFECMVGLTLKRNPM 546

  Fly   741 IPAGVLTQVKQEVKPIIIPHHSATTTMHTIQQ 772
                   .|..:.||..:||.......||:::
Human   547 -------SVSNDGKPSDLPHTFEYVVGHTMER 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368
		C2H2 Zn finger	251..271	CDD:275368	5/16 (31%)
		C2H2 Zn finger	279..299	CDD:275368	6/31 (19%)
		COG5048	300..723	CDD:227381	128/442 (29%)
		C2H2 Zn finger	307..327	CDD:275368	4/19 (21%)
		C2H2 Zn finger	335..355	CDD:275368	6/19 (32%)
		C2H2 Zn finger	363..383	CDD:275368	6/19 (32%)
		C2H2 Zn finger	391..411	CDD:275368	6/19 (32%)
		C2H2 Zn finger	419..439	CDD:275368	5/19 (26%)
		C2H2 Zn finger	447..467	CDD:275368	7/19 (37%)
		C2H2 Zn finger	475..495	CDD:275368	5/19 (26%)
		C2H2 Zn finger	503..523	CDD:275368	5/19 (26%)
		C2H2 Zn finger	531..551	CDD:275368	7/19 (37%)
		C2H2 Zn finger	559..579	CDD:275368	8/19 (42%)
		C2H2 Zn finger	587..607	CDD:275368	7/19 (37%)
		C2H2 Zn finger	615..636	CDD:275368	2/20 (10%)
		C2H2 Zn finger	644..664	CDD:275368	5/19 (26%)
		C2H2 Zn finger	676..696	CDD:275368	5/19 (26%)
		C2H2 Zn finger	704..722	CDD:275368	4/37 (11%)
ZNF440	XP_005259788.1	KRAB	7..>47	CDD:214630
		KRAB	7..46	CDD:279668
		C2H2 Zn finger	149..169	CDD:275368	4/19 (21%)
		C2H2 Zn finger	177..197	CDD:275368	6/19 (32%)
		zf-H2C2_2	189..214	CDD:290200	8/24 (33%)
		COG5048	202..>492	CDD:227381	105/344 (31%)
		C2H2 Zn finger	205..225	CDD:275368	6/19 (32%)
		zf-H2C2_2	221..242	CDD:290200	9/20 (45%)
		C2H2 Zn finger	233..253	CDD:275368	6/19 (32%)
		C2H2 Zn finger	261..281	CDD:275368	5/19 (26%)
		zf-H2C2_2	273..298	CDD:290200	8/24 (33%)
		C2H2 Zn finger	289..309	CDD:275368	7/19 (37%)
		C2H2 Zn finger	317..337	CDD:275368	5/19 (26%)
		C2H2 Zn finger	345..365	CDD:275368	5/19 (26%)
		zf-H2C2_2	357..380	CDD:290200	9/22 (41%)
		C2H2 Zn finger	373..393	CDD:275368	7/19 (37%)
		zf-H2C2_2	385..410	CDD:290200	11/24 (46%)
		C2H2 Zn finger	401..421	CDD:275368	8/19 (42%)
		zf-H2C2_2	413..438	CDD:290200	12/24 (50%)
		C2H2 Zn finger	429..448	CDD:275368	6/18 (33%)
		C2H2 Zn finger	463..483	CDD:275368	10/51 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810