DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZNF441

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_689568.2	Gene:	ZNF441 / 126068	HGNCID:	20875	Length:	693	Species:	Homo sapiens

Alignment Length:	507	Identity:	178/507 - (35%)
Similarity:	255/507 - (50%)	Gaps:	7/507 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   219 GTHVCDICGKMFQFRYQLIVHRRYHSERKPFMCQVCGQGFTTSQDLTRHGKIHIGGPMFTCIVCF 283
            |..:|.:||..|.:.....:.||.|:|.||:..:.|...|.......||.:.|.|...:.|..|.
Human   194 GPRICKLCGNAFIWPSLFHMLRRTHTEEKPYEYEQCSTAFPAYSSTLRHERTHSGEKPYQCKQCG 258

  Fly   284 NVFANNTSLERHMKRHSTDKPFACTICQKTFARKEHLDNHFRSHTGETPFRCQYCAKTFTRKEHM 348
            ..|:.:...:.:.:.|:.::.:.|..|.|.|........|...|||:.|.:|:.|.|.|.....:
Human   259 KAFSCSCYTQLYERTHTGEQSYECKQCGKAFYHLGSFQRHMIVHTGDGPHKCKICGKGFLSPSSV 323

  Fly   349 VNHVRKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYTRKEHLANHMRSHTN 413
            ..|.|.||||.|:.|..|.|:|:....:..|.:.|||..||:|.||||.:........|..:||.
Human   324 RRHKRTHTGEKPYECKYCGKAFSDCTGFRRHMITHTGDGPHKCKVCGKAFDSPSLCRRHETTHTG 388

  Fly   414 ETPFRCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRCSYC 478
            |.|::|| |||:||...:|.||...||||.|::|..|.|.|....:|..|.|.||||.|::|..|
Human   389 EKPYKCE-CGKAFSDFYYFRNHETTHTGEKPYKCKQCGKAFICCTYLQIHERIHTGERPYKCKQC 452

  Fly   479 MKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTGESPHKCTYCTKTFTRKEH 543
            .|.|....::..|.:.||||.|::|..|.||.:.......|:..|||:.||||..|.|:|.....
Human   453 GKAFRSSNYIRVHEKTHTGEKPYECKQCGKALSHLKSFQRHMIMHTGDGPHKCKICGKSFDSPSS 517

  Fly   544 LTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTFTRKEHLNNHMRQHS 608
            ...|.|.|||:.|::|..|.|.|....::..|.|.|||:.|:.|:.|.|..:.......||..|:
Human   518 FRRHERIHTGERPYKCKLCGKGFRSSSYIQLHERTHTGEKPYGCQQCGKALSDLSSFRRHMITHT 582

  Fly   609 SDNPHCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGKSFPLKGNLLFHQRSHTKGQEMERP 673
            .:.||.|.:|.|.|.....:..| .|.|||::|:.|:.|||:|.....|..|:|.||.    |:|
Human   583 GNGPHKCKICGKGFDYPSSVQRH-ERTHTGEKPYECKECGKAFSHSSYLRIHERVHTG----EKP 642

  Fly   674 FACEKCPKNFICKGHLVSHMRSHSGEKPHACTLCSKAFVERGNLKRHMKMNH 725
            :.|::|.|.|.|......|.|:||.|||:.|..|.:||....:..:| :|.|
Human   643 YKCKECGKPFHCPSAFHKHERTHSMEKPYKCKECGEAFHCISSFHKH-EMTH 693

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	6/19 (32%)
		C2H2 Zn finger	251..271	CDD:275368	4/19 (21%)
		C2H2 Zn finger	279..299	CDD:275368	3/19 (16%)
		COG5048	300..723	CDD:227381	155/422 (37%)
		C2H2 Zn finger	307..327	CDD:275368	5/19 (26%)
		C2H2 Zn finger	335..355	CDD:275368	6/19 (32%)
		C2H2 Zn finger	363..383	CDD:275368	5/19 (26%)
		C2H2 Zn finger	391..411	CDD:275368	6/19 (32%)
		C2H2 Zn finger	419..439	CDD:275368	10/19 (53%)
		C2H2 Zn finger	447..467	CDD:275368	7/19 (37%)
		C2H2 Zn finger	475..495	CDD:275368	5/19 (26%)
		C2H2 Zn finger	503..523	CDD:275368	5/19 (26%)
		C2H2 Zn finger	531..551	CDD:275368	6/19 (32%)
		C2H2 Zn finger	559..579	CDD:275368	6/19 (32%)
		C2H2 Zn finger	587..607	CDD:275368	5/19 (26%)
		C2H2 Zn finger	615..636	CDD:275368	6/20 (30%)
		C2H2 Zn finger	644..664	CDD:275368	8/19 (42%)
		C2H2 Zn finger	676..696	CDD:275368	7/19 (37%)
		C2H2 Zn finger	704..722	CDD:275368	5/17 (29%)
ZNF441	NP_689568.2	KRAB	4..>44	CDD:214630
		KRAB	4..40	CDD:279668
		C2H2 Zn finger	143..163	CDD:275368
		C2H2 Zn finger	171..190	CDD:275368
		C2H2 Zn finger	198..218	CDD:275368	6/19 (32%)
		COG5048	222..634	CDD:227381	144/413 (35%)
		C2H2 Zn finger	227..246	CDD:275368	4/18 (22%)
		zf-H2C2_2	241..263	CDD:290200	7/21 (33%)
		C2H2 Zn finger	254..274	CDD:275368	3/19 (16%)
		C2H2 Zn finger	282..302	CDD:275368	5/19 (26%)
		C2H2 Zn finger	310..330	CDD:275368	6/19 (32%)
		zf-H2C2_2	322..346	CDD:290200	10/23 (43%)
		C2H2 Zn finger	338..358	CDD:275368	5/19 (26%)
		zf-H2C2_2	351..375	CDD:290200	11/23 (48%)
		C2H2 Zn finger	366..386	CDD:275368	6/19 (32%)
		C2H2 Zn finger	395..413	CDD:275368	9/18 (50%)
		zf-H2C2_2	405..428	CDD:290200	11/22 (50%)
		C2H2 Zn finger	421..441	CDD:275368	7/19 (37%)
		zf-H2C2_2	433..458	CDD:290200	12/24 (50%)
		C2H2 Zn finger	449..469	CDD:275368	5/19 (26%)
		C2H2 Zn finger	477..497	CDD:275368	5/19 (26%)
		zf-H2C2_2	489..514	CDD:290200	11/24 (46%)
		C2H2 Zn finger	505..525	CDD:275368	6/19 (32%)
		zf-H2C2_2	517..542	CDD:290200	10/24 (42%)
		C2H2 Zn finger	533..553	CDD:275368	6/19 (32%)
		C2H2 Zn finger	561..581	CDD:275368	5/19 (26%)
		C2H2 Zn finger	589..609	CDD:275368	6/20 (30%)
		zf-H2C2_2	601..626	CDD:290200	11/25 (44%)
		C2H2 Zn finger	617..637	CDD:275368	8/19 (42%)
		zf-H2C2_2	629..654	CDD:290200	11/28 (39%)
		C2H2 Zn finger	645..665	CDD:275368	7/19 (37%)
		C2H2 Zn finger	673..693	CDD:275368	6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	499	1.000	Inparanoid score	I1378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.860