DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZNF813

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_001004301.2	Gene:	ZNF813 / 126017	HGNCID:	33257	Length:	617	Species:	Homo sapiens

Alignment Length:	502	Identity:	198/502 - (39%)
Similarity:	267/502 - (53%)	Gaps:	44/502 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   190 IHGVDGSGNGGNGGGQNVALAPDGTPIATG--------THVCDICGKMFQFRYQLIVHRRYHSER 246
            :|.....|..||...:::   .|.:.|:|.        ||:.:..|..|:....|...:..|...
Human   151 LHMFQTQGKIGNQVEKSI---NDASSISTSQRISCRPKTHISNNYGNNFRNSSLLTQKQEVHMRE 212

  Fly   247 KPFMCQVCGQGFTTSQDLTRHGKIHIGGPMFTCIVCFNVFANNTSLERHMKRHSTDKPFACTICQ 311
            |.|.|...|:.|..|..|.:|..||:|                            :|.:.|.:|.
Human   213 KSFQCNESGKAFNYSSLLRKHQIIHLG----------------------------EKQYKCDVCG 249

  Fly   312 KTFARKEHLDNHFRSHTGETPFRCQYCAKTFTRKEHMVNHVRKHTGETPHRCDICKKSFTRKEHY 376
            |.|.||.:|..|.|.||||.|:||..|.|||::...:..|.|.||||.|::|:.|.|:|:.|.:.
Human   250 KVFNRKRNLVCHRRCHTGEKPYRCNECGKTFSQTYSLTCHRRLHTGEKPYKCEECDKAFSFKSNL 314

  Fly   377 VNHYMWHTGQTPHQCDVCGKKYTRKEHLANHMRSHTNETPFRCEICGKSFSRKEHFTNHILWHTG 441
            ..|...|.|:.|::|:.|||.:::...|..|.|.||.|.||:|..|||:||||...|.|...|||
Human   315 KRHRRIHAGEKPYKCNECGKTFSQTSSLTCHRRLHTGEKPFKCNECGKTFSRKSSLTCHHRLHTG 379

  Fly   442 ETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRCSYCMKTFTRKEHLVNHIRQHTGETPFKCTYC 506
            |.|::|:.|.|||:::..|..|.|.||||.|::|:.|.|.|.:|.:|..|.|.|:||.|:|||.|
Human   380 EKPYKCNECGKTFSQELTLKCHRRLHTGEKPYKCNECGKVFNKKANLARHHRLHSGEKPYKCTEC 444

  Fly   507 TKAFTRKDHMVNHVRQHTGESPHKCTYCTKTFTRKEHLTNHVRQHTGDSPHRCSYCKKTFTRKEH 571
            .|.|:|...:|.|...|.||..:||..|.|||:|...|..|...|||:.|::|:.|.|.|.||.|
Human   445 VKTFSRNSALVIHKAIHIGEKRYKCNECGKTFSRISALVIHTAIHTGEKPYKCNECGKGFNRKTH 509

  Fly   572 LTNHVRLHTGDSPHKCEYCQKTFTRKEHLNNHMRQHSSDNPHCCNVCNKPFTRKEHLINHMSRCH 636
            |..|.|||||:.|:||..|.|.|.||.||.:|.|.|:.|.|:.||.|.|.|.:|.||..| .|.|
Human   510 LACHHRLHTGEKPYKCNECGKVFNRKTHLAHHHRLHTGDKPYKCNECGKVFNQKAHLARH-HRLH 573

  Fly   637 TGDRPFTCETCGKSFPLKGNLLFHQRSHTKGQEMERPFACEKCPKNF 683
            ||::|:.|..|||.|..|.||..|.|.||.    |:|:...:|.|.|
Human   574 TGEKPYKCNECGKVFNQKANLARHHRLHTG----EKPYKFNECGKAF 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	3/19 (16%)
		C2H2 Zn finger	251..271	CDD:275368	6/19 (32%)
		C2H2 Zn finger	279..299	CDD:275368	0/19 (0%)
		COG5048	300..723	CDD:227381	174/384 (45%)
		C2H2 Zn finger	307..327	CDD:275368	9/19 (47%)
		C2H2 Zn finger	335..355	CDD:275368	7/19 (37%)
		C2H2 Zn finger	363..383	CDD:275368	6/19 (32%)
		C2H2 Zn finger	391..411	CDD:275368	7/19 (37%)
		C2H2 Zn finger	419..439	CDD:275368	10/19 (53%)
		C2H2 Zn finger	447..467	CDD:275368	8/19 (42%)
		C2H2 Zn finger	475..495	CDD:275368	8/19 (42%)
		C2H2 Zn finger	503..523	CDD:275368	8/19 (42%)
		C2H2 Zn finger	531..551	CDD:275368	8/19 (42%)
		C2H2 Zn finger	559..579	CDD:275368	10/19 (53%)
		C2H2 Zn finger	587..607	CDD:275368	10/19 (53%)
		C2H2 Zn finger	615..636	CDD:275368	10/20 (50%)
		C2H2 Zn finger	644..664	CDD:275368	10/19 (53%)
		C2H2 Zn finger	676..696	CDD:275368	3/8 (38%)
		C2H2 Zn finger	704..722	CDD:275368
ZNF813	NP_001004301.2	KRAB	8..>48	CDD:214630
		KRAB	8..47	CDD:279668
		COG5048	191..602	CDD:227381	182/439 (41%)
		C2H2 Zn finger	217..237	CDD:275368	6/19 (32%)
		zf-H2C2_2	230..254	CDD:290200	10/51 (20%)
		C2H2 Zn finger	245..265	CDD:275368	9/19 (47%)
		zf-H2C2_2	257..282	CDD:290200	14/24 (58%)
		C2H2 Zn finger	273..293	CDD:275368	7/19 (37%)
		zf-H2C2_2	285..309	CDD:290200	10/23 (43%)
		C2H2 Zn finger	301..321	CDD:275368	6/19 (32%)
		zf-H2C2_2	313..338	CDD:290200	8/24 (33%)
		C2H2 Zn finger	329..349	CDD:275368	7/19 (37%)
		zf-H2C2_2	341..366	CDD:290200	13/24 (54%)
		C2H2 Zn finger	357..377	CDD:275368	10/19 (53%)
		zf-H2C2_2	369..394	CDD:290200	12/24 (50%)
		C2H2 Zn finger	385..405	CDD:275368	8/19 (42%)
		zf-H2C2_2	398..421	CDD:290200	11/22 (50%)
		C2H2 Zn finger	413..433	CDD:275368	8/19 (42%)
		C2H2 Zn finger	441..461	CDD:275368	8/19 (42%)
		C2H2 Zn finger	469..489	CDD:275368	8/19 (42%)
		C2H2 Zn finger	497..517	CDD:275368	10/19 (53%)
		zf-H2C2_2	509..534	CDD:290200	14/24 (58%)
		C2H2 Zn finger	525..545	CDD:275368	10/19 (53%)
		C2H2 Zn finger	553..573	CDD:275368	10/20 (50%)
		zf-H2C2_2	565..590	CDD:290200	13/25 (52%)
		C2H2 Zn finger	581..601	CDD:275368	10/19 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	499	1.000	Inparanoid score	I1378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.950