DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZNF543

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_998763.2	Gene:	ZNF543 / 125919	HGNCID:	25281	Length:	600	Species:	Homo sapiens

Alignment Length:	491	Identity:	173/491 - (35%)
Similarity:	238/491 - (48%)	Gaps:	56/491 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   148 GNGGQQVTVTTTSSSTSSG-GSTTSGGTTTTAGELLMPKMEGGIHGVDGSGNGGNGGGQNVALAP 211
            |.|.|:..:....||...| ||.....|..|..::   ..||.::..|..|
Human   138 GIGPQRGKLLEKMSSERDGLGSDDGVCTKITQKQV---STEGDLYECDSHG-------------- 185

  Fly   212 DGTPIA-------TGTHVCDICGKMFQFRYQLIVHRRYHSERKPFMCQVCGQGFTTSQDLTRHGK 269
               |:.       ..::.|:.|||:|:....|:.|.|.|::.||:.|..||:.|:.|..|.:|..
Human   186 ---PVTDALIREEKNSYKCEECGKVFKKNALLVQHERIHTQVKPYECTECGKTFSKSTHLLQHLI 247

  Fly   270 IHIGGPMFTCIVCFNVFANNTSLERHMKRHSTDKPFACTICQKTFARKEHLDNHFRSHTGETPFR 334
            ||.|                            :||:.|..|.|.|.|:.||..|.|.|:||.|::
Human   248 IHTG----------------------------EKPYKCMECGKAFNRRSHLTRHQRIHSGEKPYK 284

  Fly   335 CQYCAKTFTRKEHMVNHVRKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYT 399
            |..|.|.||.:...|.|.|.||||.|..|..|.|:|..:..::.||:.|||:.|::|..|||.:.
Human   285 CSECGKAFTHRSTFVLHHRSHTGEKPFVCKECGKAFRDRPGFIRHYIIHTGEKPYECIECGKAFN 349

  Fly   400 RKEHLANHMRSHTNETPFRCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNHV 464
            |:.:|..|.:.||...||.|..|||:|........|.:.||||.|::|..|.|.|.|:.||..|.
Human   350 RRSYLTWHQQIHTGVKPFECNECGKAFCESADLIQHYIIHTGEKPYKCMECGKAFNRRSHLKQHQ 414

  Fly   465 RQHTGESPHRCSYCMKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTGESPH 529
            |.||||.|:.||.|.|.||.....|.|.|.||||.|::|..|.|||:.:..::.|...||||.|:
Human   415 RIHTGEKPYECSECGKAFTHCSTFVLHKRTHTGEKPYECKECGKAFSDRADLIRHFSIHTGEKPY 479

  Fly   530 KCTYCTKTFTRKEHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTF 594
            :|..|.|.|.|..|||.|.:.|||:.|:.|..|.|.|.|..:|..|..:|||:.|::|..|.|.|
Human   480 ECVECGKAFNRSSHLTRHQQIHTGEKPYECIQCGKAFCRSANLIRHSIIHTGEKPYECSECGKAF 544

  Fly   595 TRKEHLNNHMRQHSSDNPHCCNVCNKPFTRKEHLIN 630
            .|...|.:|.|.|:..||.......:||...:..:|
Human   545 NRGSSLTHHQRIHTGRNPTIVTDVGRPFMTAQTSVN 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	8/19 (42%)
		C2H2 Zn finger	251..271	CDD:275368	7/19 (37%)
		C2H2 Zn finger	279..299	CDD:275368	0/19 (0%)
		COG5048	300..723	CDD:227381	137/331 (41%)
		C2H2 Zn finger	307..327	CDD:275368	9/19 (47%)
		C2H2 Zn finger	335..355	CDD:275368	8/19 (42%)
		C2H2 Zn finger	363..383	CDD:275368	6/19 (32%)
		C2H2 Zn finger	391..411	CDD:275368	7/19 (37%)
		C2H2 Zn finger	419..439	CDD:275368	6/19 (32%)
		C2H2 Zn finger	447..467	CDD:275368	9/19 (47%)
		C2H2 Zn finger	475..495	CDD:275368	9/19 (47%)
		C2H2 Zn finger	503..523	CDD:275368	6/19 (32%)
		C2H2 Zn finger	531..551	CDD:275368	9/19 (47%)
		C2H2 Zn finger	559..579	CDD:275368	7/19 (37%)
		C2H2 Zn finger	587..607	CDD:275368	8/19 (42%)
		C2H2 Zn finger	615..636	CDD:275368	3/16 (19%)
		C2H2 Zn finger	644..664	CDD:275368
		C2H2 Zn finger	676..696	CDD:275368
		C2H2 Zn finger	704..722	CDD:275368
ZNF543	NP_998763.2	KRAB	9..69	CDD:214630
		COG5048	<75..329	CDD:227381	68/238 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	110..131
		C2H2 Zn finger	201..221	CDD:275368	8/19 (42%)
		COG5048	223..562	CDD:227381	144/366 (39%)
		C2H2 Zn finger	229..249	CDD:275368	7/19 (37%)
		C2H2 Zn finger	257..277	CDD:275368	9/19 (47%)
		C2H2 Zn finger	285..305	CDD:275368	8/19 (42%)
		C2H2 Zn finger	313..333	CDD:275368	6/19 (32%)
		C2H2 Zn finger	341..361	CDD:275368	7/19 (37%)
		C2H2 Zn finger	369..389	CDD:275368	6/19 (32%)
		C2H2 Zn finger	397..417	CDD:275368	9/19 (47%)
		C2H2 Zn finger	425..445	CDD:275368	9/19 (47%)
		C2H2 Zn finger	453..473	CDD:275368	6/19 (32%)
		C2H2 Zn finger	481..501	CDD:275368	9/19 (47%)
		C2H2 Zn finger	509..529	CDD:275368	7/19 (37%)
		C2H2 Zn finger	537..557	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810