Protein Alignment crol and ZNF274

DIOPT Version :9

• Sequence 1: NP_001245993.1
• Gene: crol / 34592
• FlyBaseID: FBgn0020309
• Length: 962
• Species: Drosophila melanogaster
• Sequence 2: NP_598009.1
• Gene: ZNF274 / 10782
• HGNCID: 13068
• Length: 653
• Species: Homo sapiens
• Alignment Length: 202
• Identity: 69/202 - (34%)
• Similarity: 101/202 - (50%)
• Gaps: 18/202 - (8%)

  Fly   294 RHMKRHSTDKPFACTICQKTFARKEHLDNHFRSHTGETPFRCQYCAKTFTRKEHMVNHVRKHTGE 358
            :.||.:|..|     |.||:..|::..:.:             .|.|||:|....:..:|.|.|.
Human   458 KSMKHNSRVK-----IHQKSCERQKAKEGN-------------GCRKTFSRSTKQITFIRIHKGS 504

  Fly   359 TPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYTRKEHLANHMRSHTNETPFRCEICG 423
            ...||..|.|.|....::..|...|||:.|:.|..|||.:.:...|..|.|.|:.|.||.|:.||
Human   505 QVCRCSECGKIFRNPRYFSVHKKIHTGERPYVCQDCGKGFVQSSSLTQHQRVHSGERPFECQECG 569

  Fly   424 KSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRCSYCMKTFTRKEHL 488
            ::|:.:...:.|:..|||..|::|..|.|.|.:..||:.|.|.||||.|:.|:.|.|.||:..||
Human   570 RTFNDRSAISQHLRTHTGAKPYKCQDCGKAFRQSSHLIRHQRTHTGERPYACNKCGKAFTQSSHL 634

  Fly   489 VNHIRQH 495
            :.|.|.|
Human   635 IGHQRTH 641

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368
		C2H2 Zn finger	251..271	CDD:275368
		C2H2 Zn finger	279..299	CDD:275368	2/4 (50%)
		COG5048	300..723	CDD:227381	67/196 (34%)
		C2H2 Zn finger	307..327	CDD:275368	4/19 (21%)
		C2H2 Zn finger	335..355	CDD:275368	6/19 (32%)
		C2H2 Zn finger	363..383	CDD:275368	5/19 (26%)
		C2H2 Zn finger	391..411	CDD:275368	7/19 (37%)
		C2H2 Zn finger	419..439	CDD:275368	5/19 (26%)
		C2H2 Zn finger	447..467	CDD:275368	8/19 (42%)
		C2H2 Zn finger	475..495	CDD:275368	9/19 (47%)
		C2H2 Zn finger	503..523	CDD:275368
		C2H2 Zn finger	531..551	CDD:275368
		C2H2 Zn finger	559..579	CDD:275368
		C2H2 Zn finger	587..607	CDD:275368
		C2H2 Zn finger	615..636	CDD:275368
		C2H2 Zn finger	644..664	CDD:275368
		C2H2 Zn finger	676..696	CDD:275368
		C2H2 Zn finger	704..722	CDD:275368
ZNF274	NP_598009.1	KRAB	14..73	CDD:214630
		KRAB	14..53	CDD:279668
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	139..159
		SCAN	157..269	CDD:128708
		SCAN	157..245	CDD:280241
		KRAB	287..>327	CDD:214630
		KRAB	287..326	CDD:279668
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	339..359
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	388..414
		COG5048	<389..644	CDD:227381	69/202 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	448..485		8/44 (18%)
		C2H2 Zn finger	481..501	CDD:275368	6/32 (19%)
		C2H2 Zn finger	509..529	CDD:275368	5/19 (26%)
		zf-H2C2_2	521..546	CDD:290200	9/24 (38%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		zf-H2C2_2	549..573	CDD:290200	10/23 (43%)
		zf-C2H2	563..585	CDD:278523	6/21 (29%)
		C2H2 Zn finger	565..585	CDD:275368	5/19 (26%)
		zf-C2H2	591..613	CDD:278523	8/21 (38%)
		C2H2 Zn finger	593..613	CDD:275368	8/19 (42%)
		zf-H2C2_2	605..630	CDD:290200	13/24 (54%)
		C2H2 Zn finger	621..641	CDD:275368	9/19 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	632..653		5/10 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23226
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100