DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZNF267

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_003405.4	Gene:	ZNF267 / 10308	HGNCID:	13060	Length:	743	Species:	Homo sapiens

Alignment Length:	493	Identity:	182/493 - (36%)
Similarity:	261/493 - (52%)	Gaps:	27/493 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   243 HSERK---PFMCQVCGQGFTTSQDLTRHGKIHIGGPMFTCIVCFNVFANNTSLERHMKR---HST 301
            |.:.|   .:.|..|.:..|.|....:|..|||....::    :|.:..:.|...::::   |:.
Human   258 HGQEKQEQSYKCNKCVEVCTQSLKHIQHQTIHIRENSYS----YNKYDKDLSQSSNLRKQIIHNE 318

  Fly   302 DKPFACTICQKTFARKEHLDNHFRSHTGETPFRCQYCAKTFT-------RKEHMVNHVRKHTGET 359
            :||:.|..|..:.....||..|....|.|.|.:.:.|.|.|.       .|:..::     |||.
Human   319 EKPYKCEKCGDSLNHSLHLTQHQIIPTEEKPCKWKECGKVFNLNCSLYLTKQQQID-----TGEN 378

  Fly   360 PHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYTRKEHLANHMRSHTNETPFRCEICGK 424
            .::|..|.|||||..:.:.|...|||:.|::|..|||.:....:|..|.|.||.|.|::|:.|||
Human   379 LYKCKACSKSFTRSSNLIVHQRIHTGEKPYKCKECGKAFRCSSYLTKHKRIHTGEKPYKCKECGK 443

  Fly   425 SFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRCSYCMKTFTRKEHLV 489
            :|:|....|.|...||||..::|..|||::.|..:|:.|.|.||||.|::|..|.|.|:|...|.
Human   444 AFNRSSCLTQHQTTHTGEKLYKCKVCSKSYARSSNLIMHQRVHTGEKPYKCKECGKVFSRSSCLT 508

  Fly   490 NHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTGESPHKCTYCTKTFTRKEHLTNHVRQHTGD 554
            .|.:.||||..:||..|.|.||...:::.|.|.||||.|:||..|.|.|....||..|.|.|||:
Human   509 QHRKIHTGENLYKCKVCAKPFTCFSNLIVHERIHTGEKPYKCKECGKAFPYSSHLIRHHRIHTGE 573

  Fly   555 SPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTFTRKEHLNNHMRQHSSDNPHCCNVCN 619
            .|::|..|.|:|:....||.|.|.|||:.|:.|:.|.|.|:....:..|.|.|:...|:.|..|.
Human   574 KPYKCKACSKSFSDSSGLTVHRRTHTGEKPYTCKECGKAFSYSSDVIQHRRIHTGQRPYKCEECG 638

  Fly   620 KPFTRKEHLINHMSRCHTGDRPFTCETCGKSFPLKGNLLFHQRSHTKGQEMERPFACEKCPKNFI 684
            |.|..:.:|..| .|.|||:||:.||.|||:|..:..|..|:|.||.    |||:.|::|.|.|.
Human   639 KAFNYRSYLTTH-QRSHTGERPYKCEECGKAFNSRSYLTTHRRRHTG----ERPYKCDECGKAFS 698

  Fly   685 CKGHLVSHMRSHSGEKPHACTLCSKAFVERGNLKRHMK 722
            .:.:|.:|.||||||:|:.|..|.|||..|..|..|.:
Human   699 YRSYLTTHRRSHSGERPYKCEECGKAFNSRSYLIAHQR 736

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	182/493 (37%)
		C2H2 Zn finger	251..271	CDD:275368	5/19 (26%)
		C2H2 Zn finger	279..299	CDD:275368	2/22 (9%)
		COG5048	300..723	CDD:227381	169/430 (39%)
		C2H2 Zn finger	307..327	CDD:275368	5/19 (26%)
		C2H2 Zn finger	335..355	CDD:275368	4/26 (15%)
		C2H2 Zn finger	363..383	CDD:275368	8/19 (42%)
		C2H2 Zn finger	391..411	CDD:275368	7/19 (37%)
		C2H2 Zn finger	419..439	CDD:275368	8/19 (42%)
		C2H2 Zn finger	447..467	CDD:275368	8/19 (42%)
		C2H2 Zn finger	475..495	CDD:275368	7/19 (37%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
		C2H2 Zn finger	531..551	CDD:275368	8/19 (42%)
		C2H2 Zn finger	559..579	CDD:275368	8/19 (42%)
		C2H2 Zn finger	587..607	CDD:275368	6/19 (32%)
		C2H2 Zn finger	615..636	CDD:275368	7/20 (35%)
		C2H2 Zn finger	644..664	CDD:275368	9/19 (47%)
		C2H2 Zn finger	676..696	CDD:275368	7/19 (37%)
		C2H2 Zn finger	704..722	CDD:275368	8/17 (47%)
ZNF267	NP_003405.4	KRAB	4..64	CDD:214630
		C2H2 Zn finger	269..289	CDD:275368	5/19 (26%)
		C2H2 Zn finger	297..316	CDD:275368	2/18 (11%)
		C2H2 Zn finger	324..341	CDD:275368	4/16 (25%)
		C2H2 Zn finger	353..374	CDD:275368	4/20 (20%)
		COG5048	364..730	CDD:227381	154/375 (41%)
		C2H2 Zn finger	382..402	CDD:275368	8/19 (42%)
		C2H2 Zn finger	410..430	CDD:275368	7/19 (37%)
		C2H2 Zn finger	438..458	CDD:275368	8/19 (42%)
		C2H2 Zn finger	466..486	CDD:275368	8/19 (42%)
		C2H2 Zn finger	494..514	CDD:275368	7/19 (37%)
		C2H2 Zn finger	522..542	CDD:275368	7/19 (37%)
		C2H2 Zn finger	550..570	CDD:275368	8/19 (42%)
		C2H2 Zn finger	578..598	CDD:275368	8/19 (42%)
		C2H2 Zn finger	606..626	CDD:275368	6/19 (32%)
		C2H2 Zn finger	634..654	CDD:275368	7/20 (35%)
		C2H2 Zn finger	662..682	CDD:275368	9/19 (47%)
		C2H2 Zn finger	690..710	CDD:275368	7/19 (37%)
		C2H2 Zn finger	718..738	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	499	1.000	Inparanoid score	I1378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.860