DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZNF443

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_005806.3	Gene:	ZNF443 / 10224	HGNCID:	20878	Length:	671	Species:	Homo sapiens

Alignment Length:	503	Identity:	175/503 - (34%)
Similarity:	255/503 - (50%)	Gaps:	20/503 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   227 GKMFQFRYQLIVHRRYHSERKPFMCQVCGQGFTTSQDLTRHGKIHIGGPMFTCIVCFNVFANNTS 291
            ||.|.:......|.|.|:.:||:.|:.||:.|::..:|.||..:..|...:.|.:|...|...:.
Human   147 GKAFSYHNSFQTHERLHTGKKPYDCKECGKSFSSLGNLQRHMAVQRGDGPYKCKLCGKAFFWPSL 211

  Fly   292 LERHMKRHSTDKPFACTICQKTFARKEHLDNHFRSHTGETPFRCQYCAKTFTRKEHMVNHVRKHT 356
            |..|.:.|:.:||:.|..|.|.|:.......|.|:||||.|:.|:.|:|.|......:.|.|.||
Human   212 LHMHERTHTGEKPYECKQCSKAFSFYSSYLRHERTHTGEKPYECKQCSKAFPFYSSYLRHERTHT 276

  Fly   357 GETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYTRKEHLANHMRSHTNETPFRCEI 421
            ||.|::|..|.|:|......:.|...|||:.|:.|..|||.::....|..|..:|:.|.|:.|:.
Human   277 GEKPYKCKQCSKAFPDSSSCLIHERTHTGEKPYTCKQCGKAFSVSGSLQRHETTHSAEKPYACQQ 341

  Fly   422 CGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRCSYCMKTFTRKE 486
            |||:|.....|..|::.|||..||:|..|.|.|.....|.:|.|.||||.|:.|..|.|..:.:.
Human   342 CGKAFHHLGSFQRHMIRHTGNGPHKCKICGKGFDCPSSLQSHERTHTGEKPYECKQCGKALSHRS 406

  Fly   487 HLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTGESPHKCTYCTKTFTRKEHLTNHVRQH 551
            ...:|:..|||:.|.||..|.|||........|.|.||.|.|:||..|.|.:.....|..|...|
Human   407 SFRSHMIMHTGDGPHKCKVCGKAFVYPSVFQRHERTHTAEKPYKCKQCGKAYRISSSLRRHETTH 471

  Fly   552 TGDSPHRC-------SYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTFTRKEHLNNHMRQHSS 609
            ||:.|::|       .:|.        ..||...|||:.|::|:.|.|.|:|..:|:.|.|.|:.
Human   472 TGEKPYKCKLGKACIDFCS--------FQNHKTTHTGEKPYECKECGKAFSRFRYLSRHKRTHTG 528

  Fly   610 DNPHCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGKSFPLKGNLLFHQRSHTKGQEMERPF 674
            :.|:.|..|.|.|...::|..| .|.|:|::|:.|:.|||:|......|.|:|.|.:    |:.:
Human   529 EKPYECKTCRKAFGHYDNLKVH-ERIHSGEKPYECKECGKAFSWLTCFLRHERIHMR----EKSY 588

  Fly   675 ACEKCPKNFICKGHLVSHMRSHSGEKPHACTLCSKAFVERGNLKRHMK 722
            .|.:|.|.|.....|..|.::|:||.|:.|..|.|||....:|.||.|
Human   589 ECPQCGKAFTHSRFLQGHEKTHTGENPYECKECGKAFASLSSLHRHKK 636

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	5/15 (33%)
		C2H2 Zn finger	251..271	CDD:275368	7/19 (37%)
		C2H2 Zn finger	279..299	CDD:275368	5/19 (26%)
		COG5048	300..723	CDD:227381	153/430 (36%)
		C2H2 Zn finger	307..327	CDD:275368	6/19 (32%)
		C2H2 Zn finger	335..355	CDD:275368	6/19 (32%)
		C2H2 Zn finger	363..383	CDD:275368	5/19 (26%)
		C2H2 Zn finger	391..411	CDD:275368	6/19 (32%)
		C2H2 Zn finger	419..439	CDD:275368	7/19 (37%)
		C2H2 Zn finger	447..467	CDD:275368	7/19 (37%)
		C2H2 Zn finger	475..495	CDD:275368	4/19 (21%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
		C2H2 Zn finger	531..551	CDD:275368	5/19 (26%)
		C2H2 Zn finger	559..579	CDD:275368	4/26 (15%)
		C2H2 Zn finger	587..607	CDD:275368	8/19 (42%)
		C2H2 Zn finger	615..636	CDD:275368	7/20 (35%)
		C2H2 Zn finger	644..664	CDD:275368	8/19 (42%)
		C2H2 Zn finger	676..696	CDD:275368	6/19 (32%)
		C2H2 Zn finger	704..722	CDD:275368	8/17 (47%)
ZNF443	NP_005806.3	KRAB	3..43	CDD:307490
		C2H2 Zn finger	133..163	CDD:275368	5/15 (33%)
		C2H2 Zn finger	171..191	CDD:275368	7/19 (37%)
		COG5048	196..579	CDD:227381	136/391 (35%)
		C2H2 Zn finger	199..219	CDD:275368	5/19 (26%)
		C2H2 Zn finger	227..247	CDD:275368	6/19 (32%)
		C2H2 Zn finger	255..275	CDD:275368	6/19 (32%)
		C2H2 Zn finger	283..303	CDD:275368	5/19 (26%)
		C2H2 Zn finger	311..331	CDD:275368	6/19 (32%)
		C2H2 Zn finger	339..359	CDD:275368	7/19 (37%)
		C2H2 Zn finger	367..387	CDD:275368	7/19 (37%)
		C2H2 Zn finger	395..415	CDD:275368	4/19 (21%)
		C2H2 Zn finger	423..443	CDD:275368	7/19 (37%)
		C2H2 Zn finger	451..471	CDD:275368	5/19 (26%)
		C2H2 Zn finger	506..526	CDD:275368	8/19 (42%)
		C2H2 Zn finger	534..554	CDD:275368	7/20 (35%)
		C2H2 Zn finger	562..582	CDD:275368	8/19 (42%)
		C2H2 Zn finger	590..610	CDD:275368	6/19 (32%)
		C2H2 Zn finger	618..638	CDD:275368	9/19 (47%)
		C2H2 Zn finger	651..671	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	499	1.000	Inparanoid score	I1378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.860