DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and AW146154

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_001028702.1	Gene:	AW146154 / 101835	MGIID:	2142212	Length:	468	Species:	Mus musculus

Alignment Length:	417	Identity:	161/417 - (38%)
Similarity:	226/417 - (54%)	Gaps:	5/417 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   286 FANNTSLERHMKRHSTDKPFACTICQKTFARKEHLDNHFRSHTGETPFRCQYCAKTFTRKEHMVN 350
            |..:....||.:.|:.:||...|.|.|.||.:.|...|.|.||||.|:......|.|....|:..
Mouse    56 FQRSRRYGRHERSHTGEKPSVYTQCNKAFAYQSHPQRHHRIHTGEKPYEGIQHDKAFAHHNHLPR 120

  Fly   351 HVRKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYTRKEHLANHMRSHTNET 415
            ..|.|.||.|::|:.|.|||....:...|...|:|:.||:|:.|||.:....:|..|.|:||.|.
Mouse   121 RERIHAGEKPYKCNQCGKSFAHCSYLRKHKRIHSGEKPHECNQCGKAFACHSNLRIHKRTHTGEK 185

  Fly   416 PFRCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRCSYCMK 480
            |:.|..||::|:.:.:...|...||||.|:.|:.|.:.|....||..|.|.||||.|::|:.|.|
Mouse   186 PYECNQCGQAFACQGNLRLHERTHTGEKPYECNQCGQAFASHSHLQIHKRTHTGEKPYKCNQCDK 250

  Fly   481 TFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTGESPHKCTYCTKTFTRKEHLT 545
            .|::...|..|.|.||.|.|::|..|.||:.....:..|.|.||||.|::|..|.|.|.....|.
Mouse   251 AFSQGSSLQIHKRTHTKEKPYECNQCGKAYICHSSLRIHKRTHTGEKPYECNQCGKAFASHSTLR 315

  Fly   546 NHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTFTRKEHLNNHMRQHSSD 610
            .|.|.||.:.|:.|:.|.|.|||...|..|.|.|||:.|:||:.|.|.|.::.||..|.|.|:.:
Mouse   316 IHKRTHTAEKPYECNQCGKAFTRHNSLQIHKRTHTGEKPYKCDECDKAFAQQGHLRIHKRTHTGE 380

  Fly   611 NPHCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGKSFPLKGNLLFHQRSHTKGQEMERPFA 675
            .|:.|:.|:|.|.|..||..| .|.|||::|:.|..|.|:|...|:|..|:.:||    .|:|:.
Mouse   381 KPYKCSQCDKAFARHSHLQIH-ERIHTGEKPYRCNQCNKAFAQYGSLQIHKSTHT----AEKPYK 440

  Fly   676 CEKCPKNFICKGHLVSHMRSHSGEKPH 702
            |.:|.|.|....:|..|.|:|:.|||:
Mouse   441 CNECGKTFSQLSYLKIHKRTHNREKPY 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368
		C2H2 Zn finger	251..271	CDD:275368
		C2H2 Zn finger	279..299	CDD:275368	3/12 (25%)
		COG5048	300..723	CDD:227381	157/403 (39%)
		C2H2 Zn finger	307..327	CDD:275368	8/19 (42%)
		C2H2 Zn finger	335..355	CDD:275368	4/19 (21%)
		C2H2 Zn finger	363..383	CDD:275368	6/19 (32%)
		C2H2 Zn finger	391..411	CDD:275368	7/19 (37%)
		C2H2 Zn finger	419..439	CDD:275368	5/19 (26%)
		C2H2 Zn finger	447..467	CDD:275368	7/19 (37%)
		C2H2 Zn finger	475..495	CDD:275368	7/19 (37%)
		C2H2 Zn finger	503..523	CDD:275368	6/19 (32%)
		C2H2 Zn finger	531..551	CDD:275368	7/19 (37%)
		C2H2 Zn finger	559..579	CDD:275368	9/19 (47%)
		C2H2 Zn finger	587..607	CDD:275368	8/19 (42%)
		C2H2 Zn finger	615..636	CDD:275368	9/20 (45%)
		C2H2 Zn finger	644..664	CDD:275368	7/19 (37%)
		C2H2 Zn finger	676..696	CDD:275368	7/19 (37%)
		C2H2 Zn finger	704..722	CDD:275368
AW146154	NP_001028702.1	KRAB	4..>45	CDD:214630
		KRAB	4..43	CDD:279668
		C2H2 Zn finger	77..97	CDD:275368	8/19 (42%)
		C2H2 Zn finger	109..125	CDD:275368	4/15 (27%)
		C2H2 Zn finger	133..153	CDD:275368	6/19 (32%)
		zf-H2C2_2	145..170	CDD:290200	9/24 (38%)
		COG5048	157..466	CDD:227381	124/313 (40%)
		C2H2 Zn finger	161..181	CDD:275368	7/19 (37%)
		zf-H2C2_2	173..198	CDD:290200	11/24 (46%)
		C2H2 Zn finger	189..209	CDD:275368	5/19 (26%)
		zf-H2C2_2	201..226	CDD:290200	9/24 (38%)
		C2H2 Zn finger	217..237	CDD:275368	7/19 (37%)
		zf-H2C2_2	229..254	CDD:290200	13/24 (54%)
		C2H2 Zn finger	245..265	CDD:275368	7/19 (37%)
		C2H2 Zn finger	273..293	CDD:275368	6/19 (32%)
		zf-H2C2_2	285..310	CDD:290200	11/24 (46%)
		C2H2 Zn finger	301..321	CDD:275368	7/19 (37%)
		zf-H2C2_2	314..338	CDD:290200	10/23 (43%)
		C2H2 Zn finger	329..349	CDD:275368	9/19 (47%)
		zf-H2C2_2	341..366	CDD:290200	12/24 (50%)
		C2H2 Zn finger	357..377	CDD:275368	8/19 (42%)
		zf-H2C2_2	369..394	CDD:290200	10/24 (42%)
		C2H2 Zn finger	385..405	CDD:275368	9/20 (45%)
		zf-H2C2_2	397..422	CDD:290200	12/25 (48%)
		C2H2 Zn finger	413..433	CDD:275368	7/19 (37%)
		zf-H2C2_2	425..450	CDD:290200	10/28 (36%)
		C2H2 Zn finger	441..461	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.900