DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZNF256

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_005764.2	Gene:	ZNF256 / 10172	HGNCID:	13049	Length:	627	Species:	Homo sapiens

Alignment Length:	583	Identity:	202/583 - (34%)
Similarity:	282/583 - (48%)	Gaps:	68/583 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   199 GGNGGGQNVA--------------LAPDGTPIATGTHVCDICGKMFQFRYQLIVHRRYHSERKPF 249
            ||:|.|...|              ..|...|....|:.|:|||.:.:....|:.|:..|..:|.:
Human    54 GGSGAGDEEAPYQQSTSPQRVSQVRIPKALPSPQKTNPCEICGPVLRQILHLVEHQGTHHGQKLY 118

  Fly   250 MCQVCGQGFTTSQDLTRHGKIHIGGPMFTCIVCFNVFANNTSLERHMKRHSTDKPFACTICQKTF 314
            ....|.:....:..|.:|.|.|:|...|......::|.::.:.|      .:.|||.|....|.|
Human   119 TDGACRKQLQFTAYLHQHQKQHVGQKHFRSNGGRDMFLSSCTFE------VSGKPFTCKEVGKDF 177

  Fly   315 -------------ARKE-----------HLDNHFR---------------SHTG----ETPFRCQ 336
                         .||:           .:.||:.               .|.|    |..:.|.
Human   178 LVRSRFLQQQAAHTRKKSNRTKSAVAFHSVKNHYNWGECVKAFSYKHVRVQHQGDLIRERSYMCS 242

  Fly   337 YCAKTFTRKEHMVNHVRKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYTRK 401
            .|.|:|:....:.:|:|.||.|.|:.|..|.||:.:....:.|...|||..|||||.|||.:.||
Human   243 ECGKSFSTSCSLSDHLRVHTSEKPYTCGECGKSYRQSSSLITHRRIHTGVRPHQCDECGKLFNRK 307

  Fly   402 EHLANHMRSHTNETPFRCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNHVRQ 466
            ..|..|.|.||.|.|::|..||||||.......|...|||..|:.|..|.|:|.....|:.|.|.
Human   308 YDLLIHQRVHTGERPYKCSECGKSFSHSSSLITHQRIHTGMRPYECSECGKSFIHSSSLITHQRV 372

  Fly   467 HTGESPHRCSYCMKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTGESPHKC 531
            |||..|:.||.|.|:|::..||:.|.|.|.||.|::|:.|.|.||.:.....|.|.|||...|:|
Human   373 HTGTRPYMCSECGKSFSQSCHLIKHRRLHIGEGPYECSECGKLFTYRSRFFQHQRVHTGVRSHEC 437

  Fly   532 TYCTKTFTRKEHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTFTR 596
            ..|.|.|:||..|..|.|.|||:.|:.||.|.|:||.|.:|.:|.::|||..|::|..|.|:||.
Human   438 HECGKLFSRKFDLIVHERVHTGERPYECSECGKSFTCKSYLISHWKVHTGARPYECGECGKSFTH 502

  Fly   597 KEHLNNHMRQHSSDNPHCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGKSFPLKGNLLFHQ 661
            ...|..|.|.|:.:.|:.||.|.|.|::...||.| .|.|||:||:.|..|.|||....:|:.|:
Human   503 SSTLLQHQRVHTGERPYECNECGKFFSQSSSLIRH-RRSHTGERPYECSECWKSFSNHSSLVKHR 566

  Fly   662 RSHTKGQEMERPFACEKCPKNFICKGHLVSHMRSHSGEKPHACTLCSKAFVERGNLKRHMKMN 724
            |.||.    |||:.|.:|.|:|....:|.:|.|.||||:|:.|:.|.|.|....||.:|..::
Human   567 RVHTG----ERPYECSECGKSFSQSSNLTNHQRIHSGERPYECSDCGKFFTFNSNLLKHQNVH 625

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	6/19 (32%)
		C2H2 Zn finger	251..271	CDD:275368	4/19 (21%)
		C2H2 Zn finger	279..299	CDD:275368	2/19 (11%)
		COG5048	300..723	CDD:227381	177/465 (38%)
		C2H2 Zn finger	307..327	CDD:275368	7/58 (12%)
		C2H2 Zn finger	335..355	CDD:275368	6/19 (32%)
		C2H2 Zn finger	363..383	CDD:275368	5/19 (26%)
		C2H2 Zn finger	391..411	CDD:275368	10/19 (53%)
		C2H2 Zn finger	419..439	CDD:275368	8/19 (42%)
		C2H2 Zn finger	447..467	CDD:275368	7/19 (37%)
		C2H2 Zn finger	475..495	CDD:275368	9/19 (47%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
		C2H2 Zn finger	531..551	CDD:275368	9/19 (47%)
		C2H2 Zn finger	559..579	CDD:275368	9/19 (47%)
		C2H2 Zn finger	587..607	CDD:275368	8/19 (42%)
		C2H2 Zn finger	615..636	CDD:275368	9/20 (45%)
		C2H2 Zn finger	644..664	CDD:275368	8/19 (42%)
		C2H2 Zn finger	676..696	CDD:275368	7/19 (37%)
		C2H2 Zn finger	704..722	CDD:275368	7/17 (41%)
ZNF256	NP_005764.2	KRAB	14..54	CDD:366587	202/583 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	55..76		4/20 (20%)
		C2H2 Zn finger	215..233	CDD:275368	2/17 (12%)
		C2H2 Zn finger	241..261	CDD:275368	6/19 (32%)
		C2H2 Zn finger	269..289	CDD:275368	5/19 (26%)
		COG5048	293..626	CDD:227381	146/338 (43%)
		C2H2 Zn finger	297..317	CDD:275368	10/19 (53%)
		C2H2 Zn finger	325..345	CDD:275368	8/19 (42%)
		C2H2 Zn finger	353..373	CDD:275368	7/19 (37%)
		C2H2 Zn finger	381..401	CDD:275368	9/19 (47%)
		C2H2 Zn finger	409..429	CDD:275368	7/19 (37%)
		C2H2 Zn finger	437..457	CDD:275368	9/19 (47%)
		C2H2 Zn finger	465..485	CDD:275368	9/19 (47%)
		C2H2 Zn finger	493..513	CDD:275368	8/19 (42%)
		C2H2 Zn finger	521..541	CDD:275368	9/20 (45%)
		C2H2 Zn finger	549..569	CDD:275368	8/19 (42%)
		C2H2 Zn finger	577..597	CDD:275368	7/19 (37%)
		C2H2 Zn finger	605..625	CDD:275368	7/19 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	499	1.000	Inparanoid score	I1378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.860