DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and Zfp729b

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_001156718.1	Gene:	Zfp729b / 100416706	MGIID:	2145180	Length:	1045	Species:	Mus musculus

Alignment Length:	498	Identity:	180/498 - (36%)
Similarity:	262/498 - (52%)	Gaps:	5/498 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   223 CDICGKMFQFRYQLIVHRRYHSERKPFMCQVCGQGFTTSQDLTRHGKIHIGGPMFTCIVCFNVFA 287
            |::|||.|.:..:|..|.:.|:..||:.|:||.:.|.:...|::|.:||:|...:...:|.|.|.
Mouse   330 CEVCGKAFDYPSRLSTHAKMHTGEKPYKCEVCEKAFRSLSSLSKHRRIHMGDNYYNSELCSNAFV 394

  Fly   288 NNTSLERHMKRHSTDKPFACTICQKTFARKEHLDNHFRSHTGETPFRCQYCAKTFTRKEHMVNHV 352
            ..:.|.:|.|....:||:.|.:|.|.|.....|..|...||||..::|:.|.|.|.....:..|.
Mouse   395 YPSRLSKHKKICRGEKPYKCEVCGKAFHVSSLLSKHRTIHTGEKLYKCEVCGKAFYYPSRLSTHK 459

  Fly   353 RKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYTRKEHLANHMRSHTNETPF 417
            |.||||.|::|::|.|:|........|...|||:.|::|..|||.:.....|:.|.:.||.|.|:
Mouse   460 RIHTGEKPYKCEVCGKAFCFPPSLSKHKRIHTGEKPYKCKECGKAFRFPSSLSAHKKIHTGEKPY 524

  Fly   418 RCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRCSYCMKTF 482
            :||:|||:|......:.|.:.||||.|::||.|.:.|.....|.:|...||||.|::|..|.|.|
Mouse   525 KCEVCGKAFHYPSLLSKHKIIHTGEKPYKCDICDQAFHVPSKLSHHKIIHTGEKPYKCEVCGKAF 589

  Fly   483 TRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTGESPHKCTYCTKTFTRKEHLTNH 547
            .....|..|...|||:.|:||..|.|||.....:.:|.:.||||.|:||..|.|.|.....|:.|
Mouse   590 HYSSLLSKHKIIHTGKKPYKCEVCDKAFHYPSRLFSHTKMHTGEKPYKCEVCGKAFCSPSSLSKH 654

  Fly   548 VRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTFTRKEHLNNHMRQHSSDNP 612
            .|.|..:..:.|..|.|||.....|:.|..:|||::.:..|.|.|.|.....|..|.:.:..:.|
Mouse   655 KRIHKVEKAYSCEICGKTFCIPLLLSKHKIIHTGENHYNSEVCSKFFVYPSRLPKHKKIYKREKP 719

  Fly   613 HCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGKSFPLKGNLLFHQRSHTKGQEMERPFACE 677
            :.|:||.|.|.....|..| .:.||.::|:.|:.|||:|.:...||.|:..||.    |:|:.||
Mouse   720 YNCDVCGKAFDYPSRLSKH-KKIHTREKPYKCDVCGKAFHIASLLLVHKGIHTG----EKPYKCE 779

  Fly   678 KCPKNFICKGHLVSHMRSHSGEKPHACTLCSKAFVERGNLKRH 720
            .|.|.|.....|..|.|.|:||||:.|.:|.|||....:|.:|
Mouse   780 DCGKAFYYPSFLSKHKRIHTGEKPYQCEVCGKAFHVSSSLSKH 822

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	7/19 (37%)
		C2H2 Zn finger	251..271	CDD:275368	6/19 (32%)
		C2H2 Zn finger	279..299	CDD:275368	6/19 (32%)
		COG5048	300..723	CDD:227381	155/421 (37%)
		C2H2 Zn finger	307..327	CDD:275368	6/19 (32%)
		C2H2 Zn finger	335..355	CDD:275368	6/19 (32%)
		C2H2 Zn finger	363..383	CDD:275368	5/19 (26%)
		C2H2 Zn finger	391..411	CDD:275368	6/19 (32%)
		C2H2 Zn finger	419..439	CDD:275368	7/19 (37%)
		C2H2 Zn finger	447..467	CDD:275368	6/19 (32%)
		C2H2 Zn finger	475..495	CDD:275368	6/19 (32%)
		C2H2 Zn finger	503..523	CDD:275368	6/19 (32%)
		C2H2 Zn finger	531..551	CDD:275368	7/19 (37%)
		C2H2 Zn finger	559..579	CDD:275368	7/19 (37%)
		C2H2 Zn finger	587..607	CDD:275368	6/19 (32%)
		C2H2 Zn finger	615..636	CDD:275368	7/20 (35%)
		C2H2 Zn finger	644..664	CDD:275368	8/19 (42%)
		C2H2 Zn finger	676..696	CDD:275368	8/19 (42%)
		C2H2 Zn finger	704..722	CDD:275368	7/17 (41%)
Zfp729b	NP_001156718.1	KRAB	5..63	CDD:214630
		KRAB	5..44	CDD:279668
		C2H2 Zn finger	78..126	CDD:275368
		C2H2 Zn finger	134..154	CDD:275368
		C2H2 Zn finger	162..182	CDD:275368
		C2H2 Zn finger	190..210	CDD:275368
		zf-H2C2_2	203..227	CDD:290200
		COG5048	214..643	CDD:227381	115/312 (37%)
		C2H2 Zn finger	218..238	CDD:275368
		zf-H2C2_2	231..254	CDD:290200
		C2H2 Zn finger	246..266	CDD:275368
		C2H2 Zn finger	274..294	CDD:275368
		C2H2 Zn finger	302..322	CDD:275368
		C2H2 Zn finger	330..350	CDD:275368	7/19 (37%)
		C2H2 Zn finger	358..378	CDD:275368	6/19 (32%)
		C2H2 Zn finger	414..434	CDD:275368	6/19 (32%)
		C2H2 Zn finger	442..462	CDD:275368	6/19 (32%)
		zf-H2C2_2	455..477	CDD:290200	10/21 (48%)
		COG5048	466..879	CDD:227381	133/362 (37%)
		C2H2 Zn finger	470..490	CDD:275368	5/19 (26%)
		zf-H2C2_2	482..505	CDD:290200	9/22 (41%)
		C2H2 Zn finger	498..518	CDD:275368	6/19 (32%)
		zf-H2C2_2	510..535	CDD:290200	12/24 (50%)
		C2H2 Zn finger	526..546	CDD:275368	7/19 (37%)
		C2H2 Zn finger	554..574	CDD:275368	6/19 (32%)
		C2H2 Zn finger	582..602	CDD:275368	6/19 (32%)
		C2H2 Zn finger	610..630	CDD:275368	6/19 (32%)
		C2H2 Zn finger	638..658	CDD:275368	7/19 (37%)
		C2H2 Zn finger	666..686	CDD:275368	7/19 (37%)
		C2H2 Zn finger	695..714	CDD:275368	6/18 (33%)
		C2H2 Zn finger	722..742	CDD:275368	7/20 (35%)
		zf-H2C2_2	735..758	CDD:290200	9/23 (39%)
		C2H2 Zn finger	750..770	CDD:275368	8/19 (42%)
		C2H2 Zn finger	778..798	CDD:275368	8/19 (42%)
		zf-H2C2_2	791..814	CDD:290200	12/22 (55%)
		C2H2 Zn finger	806..826	CDD:275368	7/17 (41%)
		C2H2 Zn finger	834..854	CDD:275368
		zf-H2C2_2	846..870	CDD:290200
		C2H2 Zn finger	862..882	CDD:275368
		C2H2 Zn finger	890..910	CDD:275368
		C2H2 Zn finger	918..938	CDD:275368
		C2H2 Zn finger	946..966	CDD:275368
		zf-H2C2_2	958..981	CDD:290200
		C2H2 Zn finger	974..994	CDD:275368
		C2H2 Zn finger	1002..1022	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	505	1.000	Inparanoid score	I1328
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.860