DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and ZNF605

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_001158187.1	Gene:	ZNF605 / 100289635	HGNCID:	28068	Length:	672	Species:	Homo sapiens

Alignment Length:	479	Identity:	195/479 - (40%)
Similarity:	272/479 - (56%)	Gaps:	5/479 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   218 TGTHVCDICGKMFQFRYQLIVHRRYHSERKPFMCQVCGQGFTTSQDLTRHGKIHIGGPMFTCIVC 282
            ||.::|..||:.|..:.||::|:|.|:..||:.|..||:.|:....||.|.:.|.|.....|..|
Human   197 TGVYLCMECGRFFNKKSQLVIHQRTHTGEKPYQCSECGKAFSQKSLLTVHQRTHSGEKPHGCSEC 261

  Fly   283 FNVFANNTSLERHMKRHSTDKPFACTICQKTFARKEHLDNHFRSHTGETPFRCQYCAKTFTRKEH 347
            ...|:..:.|..|.:.|:.:||:.|:.|.|.|:||..|..|..:||.|.|:.|..|.|.|::|..
Human   262 QKAFSRKSLLILHQRIHTGEKPYGCSECGKAFSRKSQLKRHQITHTIEKPYSCSECGKAFSQKLK 326

  Fly   348 MVNHVRKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYTRKEHLANHMRSHT 412
            ::.|.|.||||.|:.|..|.|:|..|...:.|...|||:.|:.|..|.|.::|...|..|.|.||
Human   327 LITHQRAHTGEKPYPCSHCGKAFFWKSQLITHQRTHTGKKPYGCGECQKAFSRNSLLIRHQRIHT 391

  Fly   413 NETPFRCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRCSY 477
            .|.|:.|..||::|.||.....|.:.||||..:||..|.:.|.:|..|:.|.:.|.||.|:.|..
Human   392 GEKPYECNECGEAFIRKPQLIKHQITHTGEKNYRCSDCEEAFFKKSELIRHQKIHLGEKPYGCIQ 456

  Fly   478 CMKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTGESPHKCTYCTKTFTRKE 542
            |.|||..|..|:.|.|.||||.|::|:.|.||||:|..:::|.|.||||.|::|:.|.|||:.|.
Human   457 CGKTFFGKSQLLTHHRTHTGEKPYECSECGKAFTQKSSLISHQRTHTGEKPYECSECRKTFSEKS 521

  Fly   543 HLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTFTRKEHLNNHMRQH 607
            .|.:|.|.|||:.|..||.|:|.|..|..|..|.|:|||:.|::|..|.|.|.:|..|..|.|.|
Human   522 SLIHHQRTHTGEKPFECSECRKAFAWKPQLLRHQRIHTGEKPYECSECGKAFVQKVQLIKHQRNH 586

  Fly   608 SSDNPHCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGKSFPLKGNLLFHQRSHTKGQEMER 672
            :.:..:.|:.|.|.|..|..||.| .|.|||:||:.|..|||||..|.:|:.|||.||.    ::
Human   587 TGEKTYGCSDCAKAFFEKAQLIIH-QRIHTGERPYKCGECGKSFTRKSHLMRHQRIHTG----DK 646

  Fly   673 PFACEKCPKNFICKGHLVSHMRSH 696
            .:.|.:|...|..|..|:.|.|:|
Human   647 YYGCNECGTTFNRKSQLMIHQRNH 670

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	8/19 (42%)
		C2H2 Zn finger	251..271	CDD:275368	7/19 (37%)
		C2H2 Zn finger	279..299	CDD:275368	5/19 (26%)
		COG5048	300..723	CDD:227381	167/397 (42%)
		C2H2 Zn finger	307..327	CDD:275368	8/19 (42%)
		C2H2 Zn finger	335..355	CDD:275368	7/19 (37%)
		C2H2 Zn finger	363..383	CDD:275368	6/19 (32%)
		C2H2 Zn finger	391..411	CDD:275368	7/19 (37%)
		C2H2 Zn finger	419..439	CDD:275368	7/19 (37%)
		C2H2 Zn finger	447..467	CDD:275368	6/19 (32%)
		C2H2 Zn finger	475..495	CDD:275368	9/19 (47%)
		C2H2 Zn finger	503..523	CDD:275368	9/19 (47%)
		C2H2 Zn finger	531..551	CDD:275368	9/19 (47%)
		C2H2 Zn finger	559..579	CDD:275368	9/19 (47%)
		C2H2 Zn finger	587..607	CDD:275368	8/19 (42%)
		C2H2 Zn finger	615..636	CDD:275368	9/20 (45%)
		C2H2 Zn finger	644..664	CDD:275368	11/19 (58%)
		C2H2 Zn finger	676..696	CDD:275368	7/19 (37%)
		C2H2 Zn finger	704..722	CDD:275368
ZNF605	NP_001158187.1	C2H2 Zn finger	566..586	CDD:275368	8/19 (42%)
		C2H2 Zn finger	594..614	CDD:275368	9/20 (45%)
		zf-H2C2_2	607..631	CDD:290200	15/24 (63%)
		zf-C2H2	620..642	CDD:278523	11/21 (52%)
		C2H2 Zn finger	622..642	CDD:275368	11/19 (58%)
		C2H2 Zn finger	650..670	CDD:275368	7/19 (37%)
		KRAB	7..65	CDD:214630
		KRAB	7..45	CDD:279668
		C2H2 Zn finger	176..196	CDD:275368
		COG5048	199..603	CDD:227381	162/403 (40%)
		C2H2 Zn finger	202..222	CDD:275368	8/19 (42%)
		zf-H2C2_2	215..239	CDD:290200	10/23 (43%)
		C2H2 Zn finger	230..250	CDD:275368	7/19 (37%)
		C2H2 Zn finger	258..278	CDD:275368	5/19 (26%)
		C2H2 Zn finger	286..306	CDD:275368	8/19 (42%)
		zf-H2C2_2	299..323	CDD:290200	10/23 (43%)
		C2H2 Zn finger	314..334	CDD:275368	7/19 (37%)
		C2H2 Zn finger	342..362	CDD:275368	6/19 (32%)
		C2H2 Zn finger	370..390	CDD:275368	7/19 (37%)
		zf-H2C2_2	383..407	CDD:290200	11/23 (48%)
		C2H2 Zn finger	398..418	CDD:275368	7/19 (37%)
		C2H2 Zn finger	426..446	CDD:275368	6/19 (32%)
		C2H2 Zn finger	454..474	CDD:275368	9/19 (47%)
		zf-H2C2_2	467..491	CDD:290200	13/23 (57%)
		C2H2 Zn finger	482..502	CDD:275368	9/19 (47%)
		zf-H2C2_2	494..518	CDD:290200	11/23 (48%)
		C2H2 Zn finger	510..530	CDD:275368	9/19 (47%)
		zf-H2C2_2	522..546	CDD:290200	11/23 (48%)
		C2H2 Zn finger	538..558	CDD:275368	9/19 (47%)
		zf-H2C2_2	551..575	CDD:290200	11/23 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	499	1.000	Inparanoid score	I1378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.860