DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and Gm10778

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_001136435.1	Gene:	Gm10778 / 100233208	MGIID:	3809656	Length:	499	Species:	Mus musculus

Alignment Length:	419	Identity:	160/419 - (38%)
Similarity:	226/419 - (53%)	Gaps:	5/419 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   286 FANNTSLERHMKRHSTDKPFACTICQKTFARKEHLDNHFRSHTGETPFRCQYCAKTFTRKEHMVN 350
            ||....|:.:.:..|.:||:.|..|.|.||....|..|.::||.|.|:.|.:|.|.|..:..:..
Mouse    85 FAQKRFLQTYERICSEEKPYECNQCSKAFANFRSLQKHEKNHTREKPYECNHCGKAFPSRSALQI 149

  Fly   351 HVRKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYTRKEHLANHMRSHTNET 415
            |.|.||||.|..|..|.|:|.|..:...|...|||:.|:.|:.|||.::.:.||..|...||.|.
Mouse   150 HQRTHTGEKPFDCSECGKAFARHSNLDIHKRTHTGEKPYDCNECGKAFSTRSHLQIHEIIHTGEK 214

  Fly   416 PFRCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRCSYCMK 480
            |:.|..|||:|:.:.:...|...||||.|:.|:.|...:..:..|.||.:.||||..:.|:.|.|
Mouse   215 PYVCNQCGKAFAYRSNLEAHEKTHTGEKPYECNQCGNVYASRSSLRNHEKHHTGEKLYGCNQCGK 279

  Fly   481 TFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTGESPHKCTYCTKTFTRKEHLT 545
            .|.|:..|..|.|.||||.|:.|..|.|||.|:..:..|.|.||||.|::|..|.|.|..:..|.
Mouse   280 AFARRSSLEIHERTHTGEKPYVCNQCCKAFARRSSLQIHERSHTGEKPYECNQCGKAFASRTSLQ 344

  Fly   546 NHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTFTRKEHLNNHMRQHSSD 610
            ||.:.|||:.|:.|:.|.|.|..|..|..|.|:|||:.|:.|..|.|.|..:.:|.||.:.|:.:
Mouse   345 NHEKHHTGEKPYGCNQCDKAFELKCDLQIHERIHTGEKPYVCNQCGKAFVSRRYLRNHEKHHTLE 409

  Fly   611 NPHCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGKSFPLKGNLLFHQRSHTKGQEMERPFA 675
            ..:.|:.|.|.|....:|..| .:.|||::|:.|..|||:|..:.||..|:||||.    |:.:.
Mouse   410 KLYDCSQCGKSFAIFRYLQKH-KKTHTGEKPYKCTHCGKAFAYRSNLYRHERSHTG----EKLYE 469

  Fly   676 CEKCPKNFICKGHLVSHMRSHSGEKPHAC 704
            |.:|.|.|.....|.:|.:.|.||.|:.|
Mouse   470 CNECGKAFAYHTSLHNHKKCHIGENPYEC 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368
		C2H2 Zn finger	251..271	CDD:275368
		C2H2 Zn finger	279..299	CDD:275368	3/12 (25%)
		COG5048	300..723	CDD:227381	157/405 (39%)
		C2H2 Zn finger	307..327	CDD:275368	7/19 (37%)
		C2H2 Zn finger	335..355	CDD:275368	6/19 (32%)
		C2H2 Zn finger	363..383	CDD:275368	6/19 (32%)
		C2H2 Zn finger	391..411	CDD:275368	7/19 (37%)
		C2H2 Zn finger	419..439	CDD:275368	6/19 (32%)
		C2H2 Zn finger	447..467	CDD:275368	5/19 (26%)
		C2H2 Zn finger	475..495	CDD:275368	8/19 (42%)
		C2H2 Zn finger	503..523	CDD:275368	8/19 (42%)
		C2H2 Zn finger	531..551	CDD:275368	7/19 (37%)
		C2H2 Zn finger	559..579	CDD:275368	8/19 (42%)
		C2H2 Zn finger	587..607	CDD:275368	7/19 (37%)
		C2H2 Zn finger	615..636	CDD:275368	6/20 (30%)
		C2H2 Zn finger	644..664	CDD:275368	9/19 (47%)
		C2H2 Zn finger	676..696	CDD:275368	6/19 (32%)
		C2H2 Zn finger	704..722	CDD:275368	1/1 (100%)
Gm10778	NP_001136435.1	KRAB	4..>48	CDD:214630
		KRAB	4..43	CDD:279668
		COG5048	102..458	CDD:227381	139/356 (39%)
		C2H2 Zn finger	106..126	CDD:275368	7/19 (37%)
		zf-H2C2_2	118..141	CDD:290200	9/22 (41%)
		C2H2 Zn finger	134..154	CDD:275368	6/19 (32%)
		zf-H2C2_2	146..171	CDD:290200	11/24 (46%)
		C2H2 Zn finger	162..182	CDD:275368	6/19 (32%)
		zf-H2C2_2	174..199	CDD:290200	9/24 (38%)
		C2H2 Zn finger	190..210	CDD:275368	7/19 (37%)
		zf-H2C2_2	202..227	CDD:290200	12/24 (50%)
		C2H2 Zn finger	218..238	CDD:275368	6/19 (32%)
		C2H2 Zn finger	246..266	CDD:275368	5/19 (26%)
		C2H2 Zn finger	274..294	CDD:275368	8/19 (42%)
		zf-H2C2_2	286..311	CDD:290200	13/24 (54%)
		C2H2 Zn finger	302..322	CDD:275368	8/19 (42%)
		zf-H2C2_2	314..339	CDD:290200	11/24 (46%)
		C2H2 Zn finger	330..350	CDD:275368	7/19 (37%)
		C2H2 Zn finger	358..378	CDD:275368	8/19 (42%)
		zf-H2C2_2	370..395	CDD:290200	11/24 (46%)
		C2H2 Zn finger	386..406	CDD:275368	7/19 (37%)
		C2H2 Zn finger	414..434	CDD:275368	6/20 (30%)
		zf-H2C2_2	426..451	CDD:290200	11/25 (44%)
		C2H2 Zn finger	442..462	CDD:275368	9/19 (47%)
		zf-H2C2_2	454..479	CDD:290200	12/28 (43%)
		C2H2 Zn finger	470..490	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.900