DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment crol and Rex2

DIOPT Version :9

Sequence 1:	NP_001245993.1	Gene:	crol / 34592	FlyBaseID:	FBgn0020309	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_001171238.1	Gene:	Rex2 / 100043034	MGIID:	1328322	Length:	685	Species:	Mus musculus

Alignment Length:	491	Identity:	201/491 - (40%)
Similarity:	275/491 - (56%)	Gaps:	7/491 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   235 QLIVHRRYHSERKPFMCQVCGQGFTTSQDLTRHGKIHIGGPMFTCIVCFNVFANNTSLERHMKRH 299
            :::|.|:.:||...:.|....:.||.|.:|....:|:.|...:........|...:.|..|...|
Mouse   181 EVLVSRQNNSEMNTYTCGEFDKCFTQSDNLQSQQRIYPGKKSYKYSESDKCFTQTSHLSIHHTIH 245

  Fly   300 STDKPFACTICQKTFARKEHLDNHFRSHTGETPFRCQYCAKTFTRKEHMVNHVRKHTGETPHRCD 364
            |.:||:.|:.|.|.|..|..|..|.|.||||.|::|..|.|.||.|..:..|.|.||||.|::|:
Mouse   246 SGEKPYKCSECDKCFTDKCTLRKHQRIHTGEKPYKCSECDKCFTDKCTLRKHQRIHTGEKPYKCN 310

  Fly   365 ICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYTRKEHLANHMRSHTNETPFRCEICGKSFSRK 429
            .|.|.||.|.....|...|||:.|::|..|.|.:|:..||:.|.|.|:.|.|::|..|.|.|:.|
Mouse   311 ECDKCFTDKGSLRVHQRIHTGEKPYKCSECDKCFTQPSHLSIHRRIHSGEKPYKCSECDKCFTDK 375

  Fly   430 EHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRCSYCMKTFTRKEHLVNHIRQ 494
            .....|...||||.|::|..|.|.||.|..|..|.|.||||.|::|:.|.|.||.|..|..|.|.
Mouse   376 CTLRKHQRIHTGEKPYKCSECDKCFTEKFTLRKHQRIHTGEKPYKCNECDKCFTDKGSLRVHQRI 440

  Fly   495 HTGETPFKCTYCTKAFTRKDHMVNHVRQHTGESPHKCTYCTKTFTRKEHLTNHVRQHTGDSPHRC 559
            ||||.|:||:.|.|.||:..|:..|.|.|:||.|:||:.|.|.||:...|:.|.|.|:|:.|::|
Mouse   441 HTGEKPYKCSECDKCFTKPSHLSIHRRIHSGEKPYKCSECDKCFTQPSPLSIHRRIHSGEKPYKC 505

  Fly   560 SYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTFTRKEHLNNHMRQHSSDNPHCCNVCNKPFTR 624
            |.|.|.||.|..|..|.|:|.|:.|:||..|.|.||:..||:.|.|.||.:.|:.|:.|:|.||.
Mouse   506 SECDKCFTDKGSLRVHQRIHIGEKPYKCSECDKCFTQPSHLSIHCRIHSGEKPYKCSECDKCFTH 570

  Fly   625 KEHL-INHMSRCHTGDRPFTCETCGKSFPLKGNLLFHQRSHTKGQEMERPFACEKCPKNFICKGH 688
            |..| ::|  |.|.|::|:.|..|.|.|..|..|..|||.||.    |:|:.|.:|.|.|..|.|
Mouse   571 KGSLRVHH--RIHAGEKPYKCSECDKCFTEKNGLRRHQRIHTG----EKPYKCSECDKCFTRKSH 629

  Fly   689 LVSHMRSHSGEKPHACTLCSKAFVERGNLKRHMKMN 724
            |..|.|.|:|||.:.|:.|.|.|.::.:|..|.|::
Mouse   630 LSIHQRIHTGEKLYKCSECDKCFTQQCHLSIHQKIH 665

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
crol	NP_001245993.1	C2H2 Zn finger	223..243	CDD:275368	2/7 (29%)
		C2H2 Zn finger	251..271	CDD:275368	5/19 (26%)
		C2H2 Zn finger	279..299	CDD:275368	3/19 (16%)
		COG5048	300..723	CDD:227381	185/423 (44%)
		C2H2 Zn finger	307..327	CDD:275368	8/19 (42%)
		C2H2 Zn finger	335..355	CDD:275368	8/19 (42%)
		C2H2 Zn finger	363..383	CDD:275368	7/19 (37%)
		C2H2 Zn finger	391..411	CDD:275368	8/19 (42%)
		C2H2 Zn finger	419..439	CDD:275368	6/19 (32%)
		C2H2 Zn finger	447..467	CDD:275368	9/19 (47%)
		C2H2 Zn finger	475..495	CDD:275368	9/19 (47%)
		C2H2 Zn finger	503..523	CDD:275368	8/19 (42%)
		C2H2 Zn finger	531..551	CDD:275368	8/19 (42%)
		C2H2 Zn finger	559..579	CDD:275368	10/19 (53%)
		C2H2 Zn finger	587..607	CDD:275368	9/19 (47%)
		C2H2 Zn finger	615..636	CDD:275368	9/21 (43%)
		C2H2 Zn finger	644..664	CDD:275368	9/19 (47%)
		C2H2 Zn finger	676..696	CDD:275368	9/19 (47%)
		C2H2 Zn finger	704..722	CDD:275368	6/17 (35%)
Rex2	NP_001171238.1	KRAB	27..67	CDD:366587
		C2H2 Zn finger	197..217	CDD:275368	5/19 (26%)
		C2H2 Zn finger	229..245	CDD:275368	3/15 (20%)
		C2H2 Zn finger	253..273	CDD:275368	8/19 (42%)
		COG5048	277..666	CDD:227381	171/395 (43%)
		C2H2 Zn finger	281..301	CDD:275368	8/19 (42%)
		C2H2 Zn finger	309..329	CDD:275368	7/19 (37%)
		C2H2 Zn finger	337..357	CDD:275368	8/19 (42%)
		C2H2 Zn finger	365..385	CDD:275368	6/19 (32%)
		C2H2 Zn finger	393..413	CDD:275368	9/19 (47%)
		C2H2 Zn finger	421..441	CDD:275368	9/19 (47%)
		C2H2 Zn finger	449..469	CDD:275368	8/19 (42%)
		C2H2 Zn finger	477..497	CDD:275368	8/19 (42%)
		C2H2 Zn finger	505..525	CDD:275368	10/19 (53%)
		C2H2 Zn finger	533..553	CDD:275368	9/19 (47%)
		C2H2 Zn finger	561..581	CDD:275368	9/21 (43%)
		C2H2 Zn finger	589..609	CDD:275368	9/19 (47%)
		C2H2 Zn finger	617..637	CDD:275368	9/19 (47%)
		C2H2 Zn finger	645..665	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	505	1.000	Inparanoid score	I1328
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100020
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.950