DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tsp33B and CD63

DIOPT Version :9

Sequence 1:	NP_523552.1	Gene:	Tsp33B / 34590	FlyBaseID:	FBgn0032376	Length:	326	Species:	Drosophila melanogaster
Sequence 2:	NP_001244318.1	Gene:	CD63 / 967	HGNCID:	1692	Length:	238	Species:	Homo sapiens

Alignment Length:	271	Identity:	58/271 - (21%)
Similarity:	100/271 - (36%)	Gaps:	72/271 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VYLHLLLITEAVIGLLILVVTAYY---HTVLTGYLSDIECRLVYGYLFGIYVFGAQVVVTFL-CS 70
            :|:.||......:||:.:.|.|..   .|::.|........:|. ...|:::|    :|.|: |.
Human    14 LYVLLLAFCACAVGLIAVGVGAQLVLSQTIIQGATPGSLLPVVI-IAVGVFLF----LVAFVGCC 73

  Fly    71 IAMWRRIWRRRCTPNIRLLLSVWAFYSCVII----ASGFGCVWNLYRGVDVLENAADTSLTRGID 131
            .|         |..|..|:::...|.|.:::    |:..|.|:.     |.:.:..:.:..:.::
Human    74 GA---------CKENYCLMITFAIFLSLIMLVEVAAAIAGYVFR-----DKVMSEFNNNFRQQME 124

  Fly   132 MYYSCPEWKLLWDGLQWHKECCGVHGYKDWMNAEWMPRRENNCTSMVLAPFACCKRSCDSCFNNF 196
            .|........:.|.:|...:|||...|.||   |.:|....|     ..|.:||......|..||
Human   125 NYPKNNHTASILDRMQADFKCCGAANYTDW---EKIPSMSKN-----RVPDSCCINVTVGCGINF 181

  Fly   197 ----LPSEG--QSIGGNSRQPFPALTVDSINANGCLPAFVSAVWNCFYILMALWVLALKFLIVL- 254
                :..||  :.|||..|:.                          .:::|...|.:.|:.||
Human   182 NEKAIHKEGCVEKIGGWLRKN--------------------------VLVVAAAALGIAFVEVLG 220

  Fly   255 ----CCMTKFI 261
                ||:.|.|
Human   221 IVFACCLVKSI 231

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tsp33B	NP_523552.1	Tetraspannin	20..256	CDD:278750	51/254 (20%)
Tsp33B	NP_523552.1	CD151_like_LEL	112..237	CDD:239408	25/130 (19%)
CD63	NP_001244318.1	Tetraspannin	10..227	CDD:395265	55/265 (21%)
		CD63_LEL	105..203	CDD:239419	26/136 (19%)
		Lysosomal targeting motif. /evidence=ECO:0000250\|UniProtKB:P41731	234..238
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3882
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	3	2.770