Protein Alignment Tsp33B and Tspan14

DIOPT Version :10

• Sequence 1: NP_523552.1
• Gene: Tsp33B / 34590
• FlyBaseID: FBgn0032376
• Length: 326
• Species: Drosophila melanogaster
• Sequence 2: NP_666040.1
• Gene: Tspan14 / 52588
• MGIID: 1196325
• Length: 270
• Species: Mus musculus
• Alignment Length: 271
• Identity: 54/271 - (19%)
• Similarity: 88/271 - (32%)
• Gaps: 89/271 - (32%)

  Fly    32 YYHTVLTGYLSDIECRLVYGYLFGIYVFGAQVV-----VTFLCSIAMW-----------RRIWRR 80
            ||.      .|:.|....|.||    :|...:|     |.|| .:.:|           .::.|.
Mouse     3 YYR------YSNAEVSCWYKYL----LFSYNIVFWLAGVVFL-GVGLWAWSEKGVLSDLTKVTRL 56

  Fly    81 RCTPNIRLLLSVWAFYSCVIIASGF-GCVWNLYRGV----------------------------D 116
            .....:.|:|.|    ..|:...|| |||..|...:                            |
Mouse    57 HGIDPVVLVLMV----GVVMFTLGFAGCVGALRENICLLKFFCGAIVLIFFLELAVAVLAFLFQD 117

  Fly   117 VLENAADTSLTRGIDMYYSCPEWKLLWDGLQWHKECCGVHGYKDW-MNAEWMPRRENNCTSMVLA 180
            .:.:.........|..|....:.:.|.|.||...:|||.:|.:|| :|..:      ||:....:
Mouse   118 WVRDRFREFFESNIKSYRDDIDLQNLIDSLQKANQCCGAYGPEDWDLNVYF------NCSGASYS 176

  Fly   181 ------PFACCKRSCDSCFNNFLPSEGQSI-----GGNSRQPFPALTVDSINANGCLPAFVSAVW 234
                  ||:||           :|...|.:     |.:.|....:...:.|...||:.|....:.
Mouse   177 REKCGVPFSCC-----------VPDPAQKVVNTQCGYDVRIQLKSKWDEFIFTKGCIQALEGWLP 230

  Fly   235 NCFYILMALWV 245
            ...||:..:::
Mouse   231 RNIYIVAGVFI 241

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tsp33B	NP_523552.1	CD151_like_LEL	112..237	CDD:239408	28/164 (17%)
Tspan14	NP_666040.1	Tetraspanin	16..258	CDD:459767	49/252 (19%)
		TM4SF9_like_LEL	113..233	CDD:239412	28/136 (21%)
		Necessary and sufficient for interaction with ADAM10. /evidence=ECO:0000250|UniProtKB:Q8NG11	114..232		28/134 (21%)