Protein Alignment Vha100-5 and STV1

DIOPT Version :10

• Sequence 1: NP_609515.1
• Gene: Vha100-5 / 34587
• FlyBaseID: FBgn0032373
• Length: 814
• Species: Drosophila melanogaster
• Sequence 2: NP_013770.1
• Gene: STV1 / 855076
• SGDID: S000004658
• Length: 890
• Species: Saccharomyces cerevisiae
• Alignment Length: 926
• Identity: 311/926 - (33%)
• Similarity: 470/926 - (50%)
• Gaps: 162/926 - (17%)

  Fly     4 MFRSEKMALCQLFIQPEAAYASIAELGEKGCVQFRDLNEEVSAFQRKYVNEVRRCDDMERRLRYV 68
            :|||..|...||:|..|........||:.......|||::::||||.|||::||.|::||.:.::
Yeast     7 IFRSADMTYVQLYIPLEVIREVTFLLGKMSVFMVMDLNKDLTAFQRGYVNQLRRFDEVERMVGFL 71

  Fly    69 ESEMKK------------DEVKLPVLRPE-------EEPIA-----PNPREIVDLEAQLEKTD-- 107
            ...::|            |:....:.:|:       .||::     ...:||.|.|::..:.|
Yeast    72 NEVVEKHAAETWKYILHIDDEGNDIAQPDMADLINTMEPLSLENVNDMVKEITDCESRARQLDES 136

  Fly   108 --------NELREM-------------------SANGASLDANFRHMQELKY----VLENTEGFF 141
                    |:|.|.                   .|....::...|.:.|.:.    :.|.....|
Yeast   137 LDSLRSKLNDLLEQRQVIFECSKFIEVNPGIAGRATNPEIEQEERDVDEFRMTPDDISETLSDAF 201

  Fly   142 S-------DQEVINLDVNRKLDPEDPANLPGAAQRGQLAFVAGVIKLERFFSFERMLWRISRGNI 199
            |       |:..:..|:.|....||.:.|....|...:  :.|.|:..:.....|:|||:.|||:
Yeast   202 SFDDETPQDRGALGNDLTRNQSVEDLSFLEQGYQHRYM--ITGSIRRTKVDILNRILWRLLRGNL 264

  Fly   200 FLRRADI-DGLVADEETGRPVLKTVFVAFFQGEQLKQRIKKVCTGYHAAVYPCPSSHAERKEMIK 263
            ..:...| :.|:..:|   .|.|..|:.|..||.|.:::|:|....:..:.   |.:....|::.
Yeast   265 IFQNFPIEEPLLEGKE---KVEKDCFIIFTHGETLLKKVKRVIDSLNGKIV---SLNTRSSELVD 323

  Fly   264 DVNVRLEDLKLVLSQSADHRSRVLNSASKHLPRWSIMVRKMKAIYHILNFFNPDVTGKCLIGEGW 328
            .:|.:::||:.:|..:.......|......||.||.|.::.|.:|..||.|..:..|  ||.|||
Yeast   324 TLNRQIDDLQRILDTTEQTLHTELLVIHDQLPVWSAMTKREKYVYTTLNKFQQESQG--LIAEGW 386

  Fly   329 VPTNDISTVQDALARASKISESSIPAFMNVIETNEMPPTYTRTNKFTNGFQNLVDSYGMASYREV 393
            ||:.::..:||:|....:...|......|||.||::||||.||||||..||::||:||:|:|:|:
Yeast   387 VPSTELIHLQDSLKDYIETLGSEYSTVFNVILTNKLPPTYHRTNKFTQAFQSIVDAYGIATYKEI 451

  Fly   394 NPALYACITFPFLFAVMFGDLGHGLILLLFASWLIIKEKQLSSI-KEEIFNIFFGGRYIIFLMGI 457
            |..|...:||||:||:||||:|||.||.|.|.:|::.|::..:: ::|||::.|.|||::.|||.
Yeast   452 NAGLATVVTFPFMFAIMFGDMGHGFILFLMALFLVLNERKFGAMHRDEIFDMAFTGRYVLLLMGA 516

  Fly   458 FSIYTGFIYNDVFSKSMNIFGSAWHMNYTRDVVEDENLKYITLRPNDTV--YKT--YPFGMDPIW 518
            ||:|||.:|||:|||||.||.|.|...             .|.|..:::  .||  ||||:|..|
Yeast   517 FSVYTGLLYNDIFSKSMTIFKSGWQWP-------------STFRKGESIEAKKTGVYPFGLDFAW 568

  Fly   519 QLADNKIIFLNTFKMKLSIIVGVIHMIFGVSMSVVNFAYYKKYASIFLEFLPQVLFLLLLFGYMV 583
            ...||.::|.|::||||||::|..||.:....|.:|:........|...|:|.::|:..:|||:.
Yeast   569 HGTDNGLLFSNSYKMKLSILMGYAHMTYSFMFSYINYRAKNSKVDIIGNFIPGLVFMQSIFGYLS 633

  Fly   584 FMMFFKWVVYNDTVEGPLSPACAPSILILFINMILQGSQDTPEPCKEFMFDGQKSIQQVFVVVAI 648
            :.:.:||  ..|.::.. .|  ||.:|.:.|||.|     .|....:.::.||..:|.|.::.|:
Yeast   634 WAIVYKW--SKDWIKDD-KP--APGLLNMLINMFL-----APGTIDDQLYSGQAKLQVVLLLAAL 688

  Fly   649 ICIPWMLLGKPLYIMIKRKTNGAPPPKPQSGGGEGHG-------EDDE----------------- 689
            :|:||:||.|||.:   |:.|      ...|||..||       |.:|
Yeast   689 VCVPWLLLYKPLTL---RRLN------KNGGGGRPHGYQSVGNIEHEEQIAQQRHSAEGFQGMII 744

  Fly   690 -----------------------MGEIFIHQAIHTIEYVLSTVSHTASYLRLWALSLAHAQLSEV 731
                                   .|::.|||.|||||:.|:.:||||||||||||||||||||.|
Yeast   745 SDVASVADSINESVGGGEQGPFNFGDVMIHQVIHTIEFCLNCISHTASYLRLWALSLAHAQLSSV 809

  Fly   732 LWNMVFSMGF---KYDSYIGGILIYVFFGAWALLTVGILVLIEGLSAFLHTLRLHWVEFMSKFYE 793
            ||:|..|..|   ...|.:..:.:...|..|.:|||.|||.:||.||.||.|||||||.||||:|
Yeast   810 LWDMTISNAFSSKNSGSPLAVMKVVFLFAMWFVLTVCILVFMEGTSAMLHALRLHWVEAMSKFFE 874

  Fly   794 GAGYAFEPFAFKTILD 809
            |.|||:|||:|:.|::
Yeast   875 GEGYAYEPFSFRAIIE 890

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-5	NP_609515.1	V_ATPase_I	27..804	CDD:460232	301/896 (34%)
STV1	NP_013770.1	V_ATPase_I	32..885	CDD:460232	301/894 (34%)