DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vha100-5 and atp6v0a2a

DIOPT Version :9

Sequence 1:	NP_001260388.1	Gene:	Vha100-5 / 34587	FlyBaseID:	FBgn0032373	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	XP_009303407.1	Gene:	atp6v0a2a / 561469	ZFINID:	ZDB-GENE-091113-4	Length:	848	Species:	Danio rerio

Alignment Length:	858	Identity:	378/858 - (44%)
Similarity:	546/858 - (63%)	Gaps:	57/858 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGDMFRSEKMALCQLFIQPEAAYASIAELGEKGCVQFRDLNEEVSAFQRKYVNEVRRCDDMERRL 65
            ||..||||:|.|.|||:|..:|||.|:||||.|.|:|||||..||:|||::|:|::||::|||.|
Zfish     1 MGSGFRSEEMCLAQLFLQSGSAYACISELGEMGLVEFRDLNPSVSSFQRRFVSEIKRCEEMERIL 65

  Fly    66 RYVESEMKKDEVKLPVLRPEEEPIAPNPREIVDLEAQLEKTDNELREMSANGASLDANFRHMQEL 130
            .|:..|::|..:.:|  ..|..|:||.|:.::::..||::.:.||.|::.|...|..|...:.|.
Zfish    66 GYLLREIRKANIAVP--EAEVPPVAPAPKNVLEIMEQLQRLEVELSEVAKNKEKLQRNLLELMEY 128

  Fly   131 KYVLENTEGFF---SDQEVINLDVNR--KLDPEDPANLPGAAQRG-QLAFVAGVIKLERFFSFER 189
            .::|..|..|.   |..|.:......  .|:.|.........:.| :|.||:|:|:..:..:|||
Zfish   129 THMLRITRSFVHSRSRHEALGPQYEEFPSLETESVTGCTSMQRLGAKLGFVSGLIQRVKVEAFER 193

  Fly   190 MLWRISRGNIFLRRADIDGLVADEETGRPVLKTVFVAFFQGEQLKQRIKKVCTGYHAAVYPCPSS 254
            ||||:.:|...|..|::|..:||.:||......||:..|.|:|:.|:::|:|..||..:||.|.:
Zfish   194 MLWRVCKGYTILSYAEVDESLADLDTGEIRKNVVFLISFWGDQIGQKVQKICDCYHCHIYPHPET 258

  Fly   255 HAERKEMIKDVNVRLEDLKLVLSQSADHRSRVLNSASKHLPRWSIMVRKMKAIYHILNFFNPDVT 319
            ..||.:::..:..|::||..||.::.|:..:||:.||:....|.:.|:||||||||||..:.|||
Zfish   259 DEERADVMDSLRTRIQDLHNVLHRTEDYLKQVLHKASESAQSWVLQVKKMKAIYHILNLCSFDVT 323

  Fly   320 GKCLIGEGWVPTNDISTVQDALARASKISESSIPAFMNVIETNEMPPTYTRTNKFTNGFQNLVDS 384
            .||||.|.|.|.:|::.::.||...|:..::::|:|:|.|.:::.|||..|:||||:|||::|::
Zfish   324 NKCLIAEVWCPVSDLANLRRALEEGSRKGDATVPSFVNRIPSSDTPPTLLRSNKFTSGFQSIVEA 388

  Fly   385 YGMASYREVNPALYACITFPFLFAVMFGDLGHGLILLLFASWLIIKEKQLSSIK--EEIFNIFFG 447
            ||:..||||:||.:..|||||||||||||||||.:|.|||.|:::.||..:..:  .||....|.
Zfish   389 YGVGDYREVSPAPFTIITFPFLFAVMFGDLGHGSVLTLFALWMVLTEKDHTRRRPGNEIRMTLFD 453

  Fly   448 GRYIIFLMGIFSIYTGFIYNDVFSKSMNIFGSAWHMN--YTRDVVEDENLK---YITLRPN-DTV 506
            |||||.:||:||||||.||||.||||:|||||||.:.  :|.....:|.|:   .:||.|| ..|
Zfish   454 GRYIILMMGLFSIYTGLIYNDCFSKSLNIFGSAWSVKAMFTEQEWTNETLRSNMLLTLNPNVSGV 518

  Fly   507 YK-TYPFGMDPIWQLADNKIIFLNTFKMKLSIIVGVIHMIFGVSMSVVNFAYYKKYASIFLEFLP 570
            :. .||.|:||||.:|.|::.|||::|||:|:|:||:||.|||.:||.|..::::...|:|.|||
Zfish   519 FSGPYPLGIDPIWNMAVNRLTFLNSYKMKMSVIIGVVHMSFGVVLSVFNHLHFRQKYKIYLLFLP 583

  Fly   571 QVLFLLLLFGYMVFMMFFKWVVYNDTVEGPLSPACAPSILILFINM-ILQGSQDTPEPCKEFMFD 634
            ::||||.||||:.||:|:||:.|.     ......||||||.|||| ::|.:..:|      ::.
Zfish   584 ELLFLLCLFGYLAFMIFYKWLAYT-----ARDSQLAPSILIHFINMFLMQANATSP------LYP 637

  Fly   635 GQKSIQQVFVVVAIICIPWMLLGKPLYI-----------------------MIKRKTNGAPPPK- 675
            ||..:|...||||::.:|.:|||||||:                       .::|.:.....|.
Zfish   638 GQMGLQVFLVVVALLSVPVLLLGKPLYLYWLHHGGKSLGIHRVCLCSCGYERVRRVSEEDLSPSV 702

  Fly   676 ---PQSGGGEGHG-EDDEMGEIFIHQAIHTIEYVLSTVSHTASYLRLWALSLAHAQLSEVLWNMV 736
               .:.|..|..| ::.:.|::|:|||||||||.|..:|:||||||||||||||||||||||.||
Zfish   703 VHDEEEGLSESGGPQEFDFGDVFLHQAIHTIEYSLGCISNTASYLRLWALSLAHAQLSEVLWAMV 767

  Fly   737 FSMGFKYDSYIGGILIYVFFGAWALLTVGILVLIEGLSAFLHTLRLHWVEFMSKFYEGAGYAFEP 801
            ..:|.:..|.:|.|.:...|..:|:||:.||:::||||||||.||||||||.:|||.|||..|.|
Zfish   768 MRLGLRISSRLGVIFLVPVFSVFAVLTISILLVMEGLSAFLHALRLHWVEFQNKFYSGAGVKFAP 832

  Fly   802 FAFKTILDVSEDD 814
            |.|..:..|.|.|
Zfish   833 FDFSLLPSVFEQD 845

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-5	NP_001260388.1	NtpI	5..805	CDD:224188	372/843 (44%)
Vha100-5	NP_001260388.1	V_ATPase_I	28..804	CDD:279793	358/819 (44%)
atp6v0a2a	XP_009303407.1	NtpI	26..833	CDD:224188	357/819 (44%)
atp6v0a2a	XP_009303407.1	V_ATPase_I	28..835	CDD:279793	358/819 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1269
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53812
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	O	PTHR11629
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X226
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.830