DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vha100-5 and atp6v0a1b

DIOPT Version :9

Sequence 1:	NP_001260388.1	Gene:	Vha100-5 / 34587	FlyBaseID:	FBgn0032373	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	XP_009295518.1	Gene:	atp6v0a1b / 553691	ZFINID:	ZDB-GENE-050522-215	Length:	868	Species:	Danio rerio

Alignment Length:	885	Identity:	416/885 - (47%)
Similarity:	582/885 - (65%)	Gaps:	88/885 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGDMFRSEKMALCQLFIQPEAAYASIAELGEKGCVQFRDLNEEVSAFQRKYVNEVRRCDDMERRL 65
            ||::||||:|.|.|||:|.||||..::||||.|.|||||||.:|:.||||:|||||||::|:|:|
Zfish     1 MGELFRSEEMTLAQLFLQSEAAYCCVSELGELGMVQFRDLNPDVNVFQRKFVNEVRRCEEMDRKL 65

  Fly    66 RYVESEMKKDEVKLPVLRPEEEPIAPNPREIVDLEAQLEKTDNELREMSANGASLDANFRHMQEL 130
            |:||.|:||  ..:|.:...|.|..|.||:::||||..||.:|||:|::.|..:|..||..:.||
Zfish    66 RFVEKEIKK--ANIPTMDTGENPEVPFPRDMIDLEATFEKLENELKEINTNQEALKKNFLELTEL 128

  Fly   131 KYVLENTEGFFSDQEVINL--DVNRKLDPEDPANLPGAAQRG---QLAFVAGVIKLERFFSFERM 190
            |::|..|:.||.:.|..||  :.:..|||.:       |.||   :|.||||||..||..:||||
Zfish   129 KHILRRTQQFFDEMEDPNLLEESSSLLDPSE-------AGRGAPLRLGFVAGVINRERIPTFERM 186

  Fly   191 LWRISRGNIFLRRADIDGLVADEETGRPVLKTVFVAFFQGEQLKQRIKKVCTGYHAAVYPCPSSH 255
            |||:.|||:|||:.:|:..:.|..||..|.|:||:.||||:|||.|:||:|.|:.|::||||.:.
Zfish   187 LWRVCRGNVFLRQTEIEDPLEDPTTGDQVHKSVFIIFFQGDQLKNRVKKICEGFRASLYPCPETP 251

  Fly   256 AERKEMIKDVNVRLEDLKLVLSQSADHRSRVLNSASKHLPRWSIMVRKMKAIYHILNFFNPDVTG 320
            .|||||...||.|::||::||:|:.|||.|||.:|:|.:..|.|.|||||||||.||..|.|||.
Zfish   252 QERKEMASGVNTRIDDLQMVLNQTEDHRQRVLQAAAKTMRVWFIKVRKMKAIYHTLNLCNIDVTQ 316

  Fly   321 KCLIGEGWVPTNDISTVQDALARASKISESSIPAFMNVIETNEMPPTYTRTNKFTNGFQNLVDSY 385
            ||||.|.|.|.:|:.::|.||.|.::.|.|::|:.:|.::|.:.||||.:|||||:||||:||:|
Zfish   317 KCLIAEVWCPVSDLDSIQFALRRGTERSGSTVPSILNRMQTKQTPPTYNKTNKFTSGFQNIVDAY 381

  Fly   386 GMASYREVNPALYACITFPFLFAVMFGDLGHGLILLLFASWLIIKEKQLSSIK--EEIFNIFFGG 448
            |:.:|||:|||.|..|||||||||||||:|||:::...|.:|:::|.:|.:.|  .|:||:.|.|
Zfish   382 GIGTYREINPAPYTIITFPFLFAVMFGDMGHGVLMTSAALYLVLRETRLLAQKSDNEMFNMIFAG 446

  Fly   449 RYIIFLMGIFSIYTGFIYNDVFSKSMNIFGSAWHM--------NYTRDVVEDENLKYITLRPNDT 505
            ||||.|||:||:|||.||||.||||:|:|.|.|.:        |:|...:|..::..:....:..
Zfish   447 RYIILLMGMFSVYTGLIYNDCFSKSLNMFSSGWSVRPMFAPNGNWTDQTLESNSVLQLNPSVSGV 511

  Fly   506 VYKTYPFGMDPIWQLADNKIIFLNTFKMKLSIIVGVIHMIFGVSMSVVNFAYYKKYASIFLEFLP 570
            ....||.|:||||.:|.||:.|||:||||:|:|:|||||:|||::|:.|..|:||..:|||.|:|
Zfish   512 FGGPYPLGIDPIWNIAANKLTFLNSFKMKMSVILGVIHMLFGVTLSLFNHLYFKKPLNIFLNFIP 576

  Fly   571 QVLFLLLLFGYMVFMMFFKWVVYNDTVEGPLSPACAPSILILFINMILQGSQDTPEPCKEFMFDG 635
            :::|:..||||::.::|:||:.|:     .::...|||:||.||||.|....|   |..:.::.|
Zfish   577 EIVFMSSLFGYLILLIFYKWIAYD-----AVTSKDAPSLLIAFINMCLFNYND---PTNKPLYRG 633

  Fly   636 QKSIQQVFVVVAIICIPWMLLGKPLYI-----------------------MIKRKTNGAPPPKPQ 677
            |..||.:.||:|:.|:|.||:.|.:.:                       .:::....:||...|
Zfish   634 QAGIQSLLVVIALACVPVMLVVKTMILRRQHLWKKHLSQMRDARPAENLETLEQTGTSSPPGLTQ 698

  Fly   678 SG-------------------------------GGEGHGEDD--EMGEIFIHQAIHTIEYVLSTV 709
            .|                               .|:.|.|::  ..|::.:|||||||||.|..:
Zfish   699 QGTQKFGGVRVGNGPTEDEAEIIDHDQLSQHSEEGDEHSEEEPFNFGDMAVHQAIHTIEYCLGCI 763

  Fly   710 SHTASYLRLWALSLAHAQLSEVLWNMVFSMGFKYDSYIGGILIYVFFGAWALLTVGILVLIEGLS 774
            |:||||||||||||||||||||||.||..:|....|..|...:.:.|.|:|.|||.||:::||||
Zfish   764 SNTASYLRLWALSLAHAQLSEVLWGMVMRLGLSSRSGGGFFGLSIIFSAFATLTVCILLIMEGLS 828

  Fly   775 AFLHTLRLHWVEFMSKFYEGAGYAFEPFAFKTILDVSEDD 814
            ||||.||||||||.:|||.|.|:.|.||:|::||:...|:
Zfish   829 AFLHALRLHWVEFQNKFYTGQGFKFVPFSFESILEGRFDE 868

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-5	NP_001260388.1	NtpI	5..805	CDD:224188	410/870 (47%)
Vha100-5	NP_001260388.1	V_ATPase_I	28..804	CDD:279793	396/846 (47%)
atp6v0a1b	XP_009295518.1	NtpI	27..860	CDD:224188	397/849 (47%)
atp6v0a1b	XP_009295518.1	V_ATPase_I	28..858	CDD:279793	396/846 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582321
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1269
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53812
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	O	PTHR11629
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X226
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.720