DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vha100-5 and tcirg1

DIOPT Version :9

Sequence 1:	NP_001260388.1	Gene:	Vha100-5 / 34587	FlyBaseID:	FBgn0032373	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	XP_012809053.3	Gene:	tcirg1 / 549603	XenbaseID:	XB-GENE-5721917	Length:	865	Species:	Xenopus tropicalis

Alignment Length:	846	Identity:	380/846 - (44%)
Similarity:	530/846 - (62%)	Gaps:	63/846 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGDMFRSEKMALCQLFIQPEAAYASIAELGEKGCVQFRDLNEEVSAFQRKYVNEVRRCDDMERRL 65
            ||.:||.|:|.|.|||:|..:.|..::.|||.|.|:|||||:.|::|||:||:|:||||:||...
Frog    43 MGSLFRGEEMCLAQLFLQSGSEYQCVSALGELGLVEFRDLNQNVNSFQRRYVSEIRRCDEMETTF 107

  Fly    66 RYVESEMKKDEVKLPVLRPEEEPIAPNPREIVDLEAQLEKTDNELREMSANGASLDANFRHMQEL 130
            .|:|.|::|..|::|  ..|..|.||.||:.:.::.:.|:...||||:|.|..:|....|.:.|.
Frog   108 SYLERELRKAGVQVP--ESEMSPPAPLPRDAIRMQEESEQLAKELREVSQNRQTLQERLRELLEY 170

  Fly   131 KYVLENTEGFFSDQEVINLDVNRKLDPEDPANLPGAAQRGQ---LAFVAGVIKLERFFSFERMLW 192
            ..:|..::.|..  .::..:...|...||...|..|....|   ::|:||||...|..||||:||
Frog   171 ANILRESQRFTG--PLLESEAQWKDRSEDDPLLDPAVVNKQDLRVSFMAGVIHPWRMNSFERLLW 233

  Fly   193 RISRGNIFLRRADIDGLVADEETGRPVLKTVFVAFFQGEQLKQRIKKVCTGYHAAVYPCPSSHAE 257
            |..||.:.:...::...:.|..||..|.:.:|:..:.||::.::|||:...:|..:||.......
Frog   234 RACRGYLIVNFVEMSEPMEDLVTGESVTQIIFLISYWGEKIGEKIKKIANCFHCHIYPYADDETS 298

  Fly   258 RKEMIKDVNVRLEDLKLVLSQSADHRSRVLNSASKHLPRWSIMVRKMKAIYHILNFFNPDVTGKC 322
            |.|.::::.|:::|::.||.|:..:.|:||:.|:..|..|.:.|||||.||.|||..:  |..:|
Frog   299 RLETLRNLLVQIQDMQKVLLQTEGYLSQVLSRAASALHHWRVSVRKMKHIYLILNLCS--VRERC 361

  Fly   323 LIGEGWVPTNDISTVQDALARASKISESSIPAFMNVIETNEMPPTYTRTNKFTNGFQNLVDSYGM 387
            ||||.|.|..|:..:|.||.|||:.|.....:|.:.|.....|||..||||||:|||.:||:||:
Frog   362 LIGEVWCPVVDLPLLQSALTRASESSGGGGESFCHRIPCAFSPPTLIRTNKFTSGFQGIVDAYGV 426

  Fly   388 ASYREVNPALYACITFPFLFAVMFGDLGHGLILLLFASWLIIKEK--QLSSIKEEIFNIFFGGRY 450
            |:|:|||||:::.|||||||||||||:|||.|:.|||.||::.|.  :|...::|||::.|||||
Frog   427 ATYQEVNPAIFSIITFPFLFAVMFGDVGHGAIMFLFALWLVLGENDPKLRRSEDEIFSMCFGGRY 491

  Fly   451 IIFLMGIFSIYTGFIYNDVFSKSMNIFGSAWHM-------NYTRDVVEDENLKYITLRPNDTVYK 508
            :|.|||..|:||||:||:.||:...||.|.|.:       |:|.|.:  ..|..|.|.||.|...
Frog   492 LILLMGALSVYTGFVYNECFSRPAVIFNSGWSVASMARANNWTSDSI--NKLPPIPLNPNITGVF 554

  Fly   509 T--YPFGMDPIWQLADNKIIFLNTFKMKLSIIVGVIHMIFGVSMSVVNFAYYKKYASIFLEFLPQ 571
            |  ||||:||||.||.|::.|||:||||:|:|:||.||.|||.:||.||.::::...|||..||:
Frog   555 TAPYPFGIDPIWSLAVNRLTFLNSFKMKMSVILGVCHMAFGVCLSVFNFVHFRQIYRIFLITLPE 619

  Fly   572 VLFLLLLFGYMVFMMFFKWVVYNDTVEGPLSPACAPSILILFINMILQGSQDTPEPCKEFMFDGQ 636
            :||||.||||:|||:.:||:|.  |.|   ....||||||.||:|.|    .|..|....::.||
Frog   620 LLFLLCLFGYLVFMVVYKWIVL--TAE---DAEWAPSILIHFIDMFL----FTQNPGNRDLYQGQ 675

  Fly   637 KSIQQVFVVVAIICIPWMLLGKPLYIMIKRKT-------------NG-----------APPPKPQ 677
            :.:|.|.|:|||:|||.:|||.|:.::|:.::             ||           .|.
Frog   676 QVVQTVLVIVAILCIPVLLLGDPICLLIQHRSKKDSSHQNRCSLNNGDREALLEDEITVPT---- 736

  Fly   678 SGGGEGHG-EDDEMGEIFIHQAIHTIEYVLSTVSHTASYLRLWALSLAHAQLSEVLWNMVFSMGF 741
               |.||| |..:..|:|:||.||||||.|..:|:|||||||||||||||||||||||||..:||
Frog   737 ---GHGHGSEKFDTAEVFMHQMIHTIEYCLGCISNTASYLRLWALSLAHAQLSEVLWNMVIRIGF 798

  Fly   742 KYDSYIGGILIYVFFGAWALLTVGILVLIEGLSAFLHTLRLHWVEFMSKFYEGAGYAFEPFAFKT 806
            ...|...||::...|..:|:|||.||:::||||||||.||||||||.:|||.|.||.|.||.|:|
Frog   799 SKLSLTWGIVLVPIFAFFAVLTVAILLIMEGLSAFLHALRLHWVEFQNKFYSGEGYKFFPFCFET 863

  Fly   807 I 807
            :
Frog   864 M 864

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-5	NP_001260388.1	NtpI	5..805	CDD:224188	376/838 (45%)
Vha100-5	NP_001260388.1	V_ATPase_I	28..804	CDD:279793	366/814 (45%)
tcirg1	XP_012809053.3	V_ATPase_I	69..861	CDD:396194	366/815 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53812
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11629
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X226
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.030