DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vha100-5 and atp6v0a2

DIOPT Version :9

Sequence 1:	NP_001260388.1	Gene:	Vha100-5 / 34587	FlyBaseID:	FBgn0032373	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_001016223.1	Gene:	atp6v0a2 / 548977	XenbaseID:	XB-GENE-960957	Length:	845	Species:	Xenopus tropicalis

Alignment Length:	881	Identity:	390/881 - (44%)
Similarity:	545/881 - (61%)	Gaps:	106/881 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGDMFRSEKMALCQLFIQPEAAYASIAELGEKGCVQFRDLNEEVSAFQRKYVNEVRRCDDMERRL 65
            ||..||||.|.|.|||:|..:||..::||||.|..:|||||.:|||||||:|.||::|::|||.|
Frog     1 MGSFFRSEAMCLAQLFLQSGSAYDCVSELGEMGLAEFRDLNPQVSAFQRKFVGEVKKCEEMERIL 65

  Fly    66 RYVESEMKKDEVKLPVLRPEEE--PIAPNPREIVDLEAQLEKTDNELREMSANGASLDANFRHMQ 128
            .|:..|::|  ..:||  |||.  |.||.|:.::|::.||:|.:.||||::.|...|..|...|.
Frog    66 GYLMQEIQK--ANIPV--PEESLTPEAPLPKHVLDIQEQLQKLEVELREVNKNKEKLQKNLLEMI 126

  Fly   129 ELKYVLENTEGFFSDQEVINLDVNRKLDPEDPAN-----LPG----------AAQR--GQLAFVA 176
            |..|:|          .|.|..|:|..:.|..|:     .|.          ..||  .:|.||:
Frog   127 EYTYML----------RVTNYLVHRSNEHETSAHSTYEEFPALEKESLIDYTCMQRLGAKLGFVS 181

  Fly   177 GVIKLERFFSFERMLWRISRGNIFLRRADIDGLVADEETGRPVLKTVFVAFFQGEQLKQRIKKVC 241
            |::...:..|||:||||:.:|...|...::|..:...:|..|....|||..:.|:|:.|::||:|
Frog   182 GLVHRAKLESFEKMLWRVCKGYTVLTYQELDEYLLHPDTEEPTRWFVFVVSYWGDQIGQKVKKIC 246

  Fly   242 TGYHAAVYPCPSSHAERKEMIKDVNVRLEDLKLVLSQSADHRSRVLNSASKHLPRWSIMVRKMKA 306
            ..|...:||..:|..||:.::.::|.|::||..|:||:.|:..:||..||:.:.:|.|.::||||
Frog   247 ECYDCHLYPYTNSAEERRNLLSELNTRIQDLHKVISQTDDYLKQVLFKASESVYKWVIQIKKMKA 311

  Fly   307 IYHILNFFNPDVTGKCLIGEGWVPTNDISTVQDALARASKISESSIPAFMNVIETNEMPPTYTRT 371
            |||:|||...|||.||||.|.|.|..|:..|:.||...|:.|..|:|:|:|.|.:|:.|||..||
Frog   312 IYHVLNFCRFDVTNKCLIAEVWCPVADLPNVRRALEEGSRKSGVSVPSFINRIPSNDTPPTLIRT 376

  Fly   372 NKFTNGFQNLVDSYGMASYREVNPALYACITFPFLFAVMFGDLGHGLILLLFASWLIIKEK--QL 434
            ||||:||||:||:||:.:|||:|||.|..|||||||||||||.|||:::.|||..:::.||  :|
Frog   377 NKFTSGFQNIVDAYGVGNYREMNPAPYTIITFPFLFAVMFGDFGHGILMSLFALCMVVFEKSPKL 441

  Fly   435 SSIKEEIFNIFFGGRYIIFLMGIFSIYTGFIYNDVFSKSMNIFGSAWHMN--YTRDV--VEDENL 495
            :..::||...||.|||||.|||:||||||.||||.||||||||||:|:::  ::.:|  .:|.:.
Frog   442 ARSQDEIMKTFFEGRYIILLMGLFSIYTGLIYNDCFSKSMNIFGSSWNVSAMFSSNVWRTQDLSN 506

  Fly   496 KYITLRPNDTVYKT--YPFGMDPIWQLADNKIIFLNTFKMKLSIIVGVIHMIFGVSMSVVNFAYY 558
            |::||.||.|...|  ||.|:||||.|:.|::.|||:||||:|:|:|||||.|||.:|..|:.::
Frog   507 KFLTLNPNVTGVLTGVYPVGIDPIWSLSTNRLSFLNSFKMKMSVILGVIHMTFGVVLSAFNYMHF 571

  Fly   559 KKYASIFLEFLPQVLFLLLLFGYMVFMMFFKWVVYNDTVEGPLSPACAPSILILFINMILQGSQD 623
            ||...|||.|:|::||::.:|||:|||:.:||:.|:     ......|||||:.||||.:....|
Frog   572 KKRFCIFLVFIPELLFMICIFGYLVFMILYKWLAYS-----AADSRNAPSILLHFINMFMFSKND 631

  Fly   624 -TPEPCKEFMFDGQKSIQQVFVVVAIICIPWMLLGKPLYIMIKRKTNGAPPPKPQSGGGE----- 682
             .|.     :|.||..||...:|:..:|:|.:|.|||||:..            |..||:
Frog   632 QIPA-----LFTGQVGIQIFLIVLVTLCVPVLLFGKPLYLYW------------QHHGGQTLRNY 679

  Fly   683 --GH-----GEDDEM----------GEI--------------------FIHQAIHTIEYVLSTVS 710
              |:     |.::|:          |||                    |:.||||||||.|..:|
Frog   680 RKGYTLVRRGSEEEISLVRSHDLEEGEINSSHEVQRDRDKEKFDFADVFMSQAIHTIEYCLGCIS 744

  Fly   711 HTASYLRLWALSLAHAQLSEVLWNMVFSMGFKYDSYIGGILIYVFFGAWALLTVGILVLIEGLSA 775
            :||.|||||||||||||||||||.|:...|...:..:|..::...|..:|.||:.||:::|||||
Frog   745 NTALYLRLWALSLAHAQLSEVLWGMIMRKGLNVEPSVGVFVLIPLFAVFAFLTIAILLVMEGLSA 809

  Fly   776 FLHTLRLHWVEFMSKFYEGAGYAFEPFAFKTILDVS 811
            |||.||||||||.:|||.||||.|.||:||.|..::
Frog   810 FLHALRLHWVEFQNKFYTGAGYKFNPFSFKHISHIN 845

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-5	NP_001260388.1	NtpI	5..805	CDD:224188	385/869 (44%)
Vha100-5	NP_001260388.1	V_ATPase_I	28..804	CDD:279793	373/845 (44%)
atp6v0a2	NP_001016223.1	NtpI	27..839	CDD:224188	373/847 (44%)
atp6v0a2	NP_001016223.1	V_ATPase_I	28..838	CDD:279793	373/845 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11629
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X226
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.110