DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vha100-5 and ATP6V0A4

DIOPT Version :9

Sequence 1:	NP_001260388.1	Gene:	Vha100-5 / 34587	FlyBaseID:	FBgn0032373	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_065683.2	Gene:	ATP6V0A4 / 50617	HGNCID:	866	Length:	840	Species:	Homo sapiens

Alignment Length:	860	Identity:	418/860 - (48%)
Similarity:	575/860 - (66%)	Gaps:	66/860 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGDMFRSEKMALCQLFIQPEAAYASIAELGEKGCVQFRDLNEEVSAFQRKYVNEVRRCDDMERRL 65
            |..:||||:|.|.|||:|.||||..:|||||.|.|||:|||..|::||||:|||||||:.:||.|
Human     1 MVSVFRSEEMCLSQLFLQVEAAYCCVAELGELGLVQFKDLNMNVNSFQRKFVNEVRRCESLERIL 65

  Fly    66 RYVESEMKKDEVKLPVLRPEEEPIAPNPREIVDLEAQLEKTDNELREMSANGASLDANFRHMQEL 130
            |::|.|| ::|:.:.:|  |:.|:.|.|||::.||..|||.:.||:|.:.|..:|..:|..:.||
Human    66 RFLEDEM-QNEIVVQLL--EKSPLTPLPREMITLETVLEKLEGELQEANQNQQALKQSFLELTEL 127

  Fly   131 KYVLENTEGFFSDQEVINLDVNRKLDPEDPANL------PGAAQRGQLAFVAGVIKLERFFSFER 189
            ||:|:.|:.||..:..:..|    ...||.:.|      | |...|:|.|:||||..||..||||
Human   128 KYLLKKTQDFFETETNLADD----FFTEDTSGLLELKAVP-AYMTGKLGFIAGVINRERMASFER 187

  Fly   190 MLWRISRGNIFLRRADIDGLVADEETGRPVLKTVFVAFFQGEQLKQRIKKVCTGYHAAVYPCPSS 254
            :||||.|||::|:.:::|..:.|..|...:.|.:|:.|:|||||:|:|||:|.|:.|.|||||..
Human   188 LLWRICRGNVYLKFSEMDAPLEDPVTKEEIQKNIFIIFYQGEQLRQKIKKICDGFRATVYPCPEP 252

  Fly   255 HAERKEMIKDVNVRLEDLKLVLSQSADHRSRVLNSASKHLPRWSIMVRKMKAIYHILNFFNPDVT 319
            ..||:||::.||||||||..|::|:..||.|:|..|:.:...|.|.|:||||:|||||..|.|||
Human   253 AVERREMLESVNVRLEDLITVITQTESHRQRLLQEAAANWHSWLIKVQKMKAVYHILNMCNIDVT 317

  Fly   320 GKCLIGEGWVPTNDISTVQDALARASKISESSIPAFMNVIETNEMPPTYTRTNKFTNGFQNLVDS 384
            .:|:|.|.|.|..|.:.::.||.:..::|.||:...|..:::...|||:.||||||.||||:||:
Human   318 QQCVIAEIWFPVADATRIKRALEQGMELSGSSMAPIMTTVQSKTAPPTFNRTNKFTAGFQNIVDA 382

  Fly   385 YGMASYREVNPALYACITFPFLFAVMFGDLGHGLILLLFASWLIIKEKQLSSIK--EEIFNIFFG 447
            ||:.||||:|||.|..|||||||||||||.|||.::||.|.|:|:.|::|.|.|  .||:|.||.
Human   383 YGVGSYREINPAPYTIITFPFLFAVMFGDCGHGTVMLLAALWMILNERRLLSQKTDNEIWNTFFH 447

  Fly   448 GRYIIFLMGIFSIYTGFIYNDVFSKSMNIFGSAWHM-----NYTRDV-VEDENLKYITLRPN-DT 505
            |||:|.||||||||||.||||.||||:|||||:|.:     |.|.:. |.:|:| |:.|.|. ..
Human   448 GRYLILLMGIFSIYTGLIYNDCFSKSLNIFGSSWSVQPMFRNGTWNTHVMEESL-YLQLDPAIPG 511

  Fly   506 VY--KTYPFGMDPIWQLADNKIIFLNTFKMKLSIIVGVIHMIFGVSMSVVNFAYYKKYASIFLEF 568
            ||  ..||||:||||.||.||:.|||::|||:|:|:|::.|:|||.:|:.|..|:::..:|.|:|
Human   512 VYFGNPYPFGIDPIWNLASNKLTFLNSYKMKMSVILGIVQMVFGVILSLFNHIYFRRTLNIILQF 576

  Fly   569 LPQVLFLLLLFGYMVFMMFFKWVVYNDTVEGPLSPACAPSILILFINMIL---QGSQDTPEPCKE 630
            :|:::|:|.||||:|||:.|||..::..|.     ..||||||.||||.|   ..|.:.|
Human   577 IPEMIFILCLFGYLVFMIIFKWCCFDVHVS-----QHAPSILIHFINMFLFNYSDSSNAP----- 631

  Fly   631 FMFDGQKSIQQVFVVVAIICIPWMLLGKPLYIMIKRKTN-----------------GAPPPKPQS 678
             ::..|:.:|..|||:|:|.:|||||.||..:....:.:                 .:..|..:|
Human   632 -LYKHQQEVQSFFVVMALISVPWMLLIKPFILRASHRKSQLQASRIQEDATENIEGDSSSPSSRS 695

  Fly   679 G--------GG-EGHGEDDEMGEIFIHQAIHTIEYVLSTVSHTASYLRLWALSLAHAQLSEVLWN 734
            |        |. :.|||:...|::|:|||||||||.|..:|:||||||||||||||||||||||.
Human   696 GQRTSADTHGALDDHGEEFNFGDVFVHQAIHTIEYCLGCISNTASYLRLWALSLAHAQLSEVLWT 760

  Fly   735 MVFSMGFKYDSYIGGILIYVFFGAWALLTVGILVLIEGLSAFLHTLRLHWVEFMSKFYEGAGYAF 799
            ||.:.|.:...:.|.:.:::.|..:|:|||.||:::||||||||.||||||||.:|||.|.||.|
Human   761 MVMNSGLQTRGWGGIVGVFIIFAVFAVLTVAILLIMEGLSAFLHALRLHWVEFQNKFYVGDGYKF 825

  Fly   800 EPFAFKTILDVSEDD 814
            .||:||.|||.:.::
Human   826 SPFSFKHILDGTAEE 840

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-5	NP_001260388.1	NtpI	5..805	CDD:224188	412/845 (49%)
Vha100-5	NP_001260388.1	V_ATPase_I	28..804	CDD:279793	397/821 (48%)
ATP6V0A4	NP_065683.2	NtpI	28..831	CDD:224188	397/822 (48%)
		V_ATPase_I	28..830	CDD:279793	397/821 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	675..704		3/28 (11%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1269
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53812
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	O	PTHR11629
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X226
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.790