DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vha100-5 and Vha100-1

DIOPT Version :9

Sequence 1:	NP_001260388.1	Gene:	Vha100-5 / 34587	FlyBaseID:	FBgn0032373	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_651672.1	Gene:	Vha100-1 / 43442	FlyBaseID:	FBgn0028671	Length:	855	Species:	Drosophila melanogaster

Alignment Length:	852	Identity:	486/852 - (57%)
Similarity:	605/852 - (71%)	Gaps:	48/852 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGDMFRSEKMALCQLFIQPEAAYASIAELGEKGCVQFRDLNEEVSAFQRKYVNEVRRCDDMERRL 65
            ||.:||||:|||||||:|.|||||.::||||.|.|||||||.:|:|||||:||||||||:|||:|
  Fly     1 MGSLFRSEEMALCQLFLQSEAAYACVSELGELGLVQFRDLNPDVNAFQRKFVNEVRRCDEMERKL 65

  Fly    66 RYVESEMKKDEVKLPVLRPEEEPIAPNPREIVDLEAQLEKTDNELREMSANGASLDANFRHMQEL 130
            ||:|.|:|||.:  |:|...|.|.||.|||::||||..||.:|||||::.|..:|..||..:.||
  Fly    66 RYLEKEIKKDGI--PMLDTGESPEAPQPREMIDLEATFEKLENELREVNQNAEALKRNFLELTEL 128

  Fly   131 KYVLENTEGFFSDQEVINL----------------DVNRKLDPEDPANLPG-----AAQRGQ--- 171
            |::|..|:.|| |:.|..:                .:....:.::.|.|.|     |:|.||
  Fly   129 KHILRKTQVFF-DESVPTVYKSSGAYSSSKYRRYPQMADNQNEDEQAQLLGEEGVRASQPGQNLK 192

  Fly   172 LAFVAGVIKLERFFSFERMLWRISRGNIFLRRADIDGLVADEETGRPVLKTVFVAFFQGEQLKQR 236
            |.||||||..||..:|||||||..|||:|||:|.|:..:.|...|..|.|:||:.||||:|||.|
  Fly   193 LGFVAGVILRERLPAFERMLWRACRGNVFLRQAMIETPLEDPTNGDQVHKSVFIIFFQGDQLKTR 257

  Fly   237 IKKVCTGYHAAVYPCPSSHAERKEMIKDVNVRLEDLKLVLSQSADHRSRVLNSASKHLPRWSIMV 301
            :||:|.|:.|.:||||.:.|:|:||...|..|:|||..||.|:.|||.|||.:|:|:|..|.:.|
  Fly   258 VKKICEGFRATLYPCPEAPADRREMAMGVMTRIEDLNTVLGQTQDHRHRVLVAAAKNLKNWFVKV 322

  Fly   302 RKMKAIYHILNFFNPDVTGKCLIGEGWVPTNDISTVQDALARASKISESSIPAFMNVIETNEMPP 366
            ||:|||||.||.||.|||.||||.|.|||..||.|:|.||.|.::.|.||:|..:|.::|.|.||
  Fly   323 RKIKAIYHTLNLFNLDVTQKCLIAECWVPLLDIETIQLALRRGTERSGSSVPPILNRMQTFENPP 387

  Fly   367 TYTRTNKFTNGFQNLVDSYGMASYREVNPALYACITFPFLFAVMFGDLGHGLILLLFASWLIIKE 431
            ||.||||||..||.|:|:||:|||||:|||.|..|||||||||||||||||.|:.||..|:|.||
  Fly   388 TYNRTNKFTKAFQALIDAYGVASYREMNPAPYTIITFPFLFAVMFGDLGHGAIMALFGLWMIRKE 452

  Fly   432 KQLSSIK--EEIFNIFFGGRYIIFLMGIFSIYTGFIYNDVFSKSMNIFGSAWHMNYTRDVVEDEN 494
            |.|::.|  .||:||||||||||||||:||:|||.||||:||||:|||||.||::|.:..|.:.
  Fly   453 KGLAAQKTDNEIWNIFFGGRYIIFLMGVFSMYTGLIYNDIFSKSLNIFGSHWHLSYNKSTVMEN- 516

  Fly   495 LKYITLRP-NDTVYKTYPFGMDPIWQLAD-NKIIFLNTFKMKLSIIVGVIHMIFGVSMSVVNFAY 557
             |::.|.| .|.....||||||||||:|. |||||.|.:|||:|||.|||||||||.||..|..|
  Fly   517 -KFLQLSPKGDYEGAPYPFGMDPIWQVAGANKIIFHNAYKMKISIIFGVIHMIFGVVMSWHNHTY 580

  Fly   558 YKKYASIFLEFLPQVLFLLLLFGYMVFMMFFKWVVYNDTVEGPLSPACAPSILILFINMILQGS- 621
            ::...|:..||:||::||||||.|||.:||.||:.:..|.:.|.|.||||||||.||:|:|..:
  Fly   581 FRNRISLLYEFIPQLVFLLLLFFYMVLLMFIKWIKFAATNDKPYSEACAPSILITFIDMVLFNTP 645

  Fly   622 QDTPEPCKEFMFDGQKSIQQVFVVVAIICIPWMLLGKPLYIMIKRKTNGAPP------------- 673
            :..||.|:.:||.||..||.:||:||:.|||.|||.|||.||..||.....|
  Fly   646 KPPPENCETYMFMGQHFIQVLFVLVAVGCIPVMLLAKPLLIMQARKQANVQPIAGATSDAEAGGV 710

  Fly   674 -PKPQSGGGEGHGEDDEMGEIFIHQAIHTIEYVLSTVSHTASYLRLWALSLAHAQLSEVLWNMVF 737
             .....|||.||.|::|:.||||||:||||||||.:||||||||||||||||||||:||||.||.
  Fly   711 SNSGSHGGGGGHEEEEELSEIFIHQSIHTIEYVLGSVSHTASYLRLWALSLAHAQLAEVLWTMVL 775

  Fly   738 SMGFKYDSYIGGILIYVFFGAWALLTVGILVLIEGLSAFLHTLRLHWVEFMSKFYEGAGYAFEPF 802
            |:|.|.:..:|||::...|..||:||||||||:|||||||||||||||||.||||:|.||||:||
  Fly   776 SIGLKQEGPVGGIVLTCVFAFWAILTVGILVLMEGLSAFLHTLRLHWVEFQSKFYKGQGYAFQPF 840

  Fly   803 AFKTILD 809
            :|..|::
  Fly   841 SFDAIIE 847

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-5	NP_001260388.1	NtpI	5..805	CDD:224188	482/842 (57%)
Vha100-5	NP_001260388.1	V_ATPase_I	28..804	CDD:279793	465/818 (57%)
Vha100-1	NP_651672.1	NtpI	27..842	CDD:224188	465/819 (57%)
Vha100-1	NP_651672.1	V_ATPase_I	28..842	CDD:279793	465/818 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451291
Domainoid	1	1.000	601	1.000	Domainoid score	I37
eggNOG	1	0.900	-	-		E1_COG1269
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	618	1.000	Inparanoid score	I211
Isobase	1	0.950	-	0	Normalized mean entropy	S598
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	1	1.000	-	-		mtm1001
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	P	PTHR11629
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X226
	12	11.750