DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vha100-5 and tcirg1b

DIOPT Version :9

Sequence 1:	NP_001260388.1	Gene:	Vha100-5 / 34587	FlyBaseID:	FBgn0032373	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_998234.1	Gene:	tcirg1b / 406342	ZFINID:	ZDB-GENE-040426-2022	Length:	822	Species:	Danio rerio

Alignment Length:	834	Identity:	368/834 - (44%)
Similarity:	532/834 - (63%)	Gaps:	50/834 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGDMFRSEKMALCQLFIQPEAAYASIAELGEKGCVQFRDLNEEVSAFQRKYVNEVRRCDDMERRL 65
            ||.:||||::.|.|||:|..:||..::||||.|.|:|||||..|:|||||:|||||||:::|:..
Zfish     1 MGSLFRSEEVCLIQLFLQSGSAYNCVSELGELGIVEFRDLNPNVNAFQRKFVNEVRRCEELEKTF 65

  Fly    66 RYVESEMKKDEVKLPVLRPEEEPIAPNPREIVDLEAQLEKTDNELREMSANGASLDANFRHMQEL 130
            .::|.|:.: .:...:..|...|.||.|||::.:|.:.|:...||||:|.|..||.:.:..:.:.
Zfish    66 AFLEQEINR-SLSQKLQPPIPMPPAPQPRELLTIEEESERLARELREVSRNRDSLRSQYTQLCQY 129

  Fly   131 KYVLENTEGFFSDQEVINLDVNRKLDPEDPANLPGAAQRGQLAFVAGVIKLERFFSFERMLWRIS 195
            :.||:.|....:.|        ..|...:|..|....|..:|:|||||:...:..:|||:|||..
Zfish   130 RGVLKQTHSLTASQ--------APLVSFEPMGLAENRQDVRLSFVAGVVHPWKVPAFERLLWRAC 186

  Fly   196 RGNIFLRRADIDGLVADEETGRPVLKTVFVAFFQGEQLKQRIKKVCTGYHAAVYPCPSSHAERKE 260
            ||.|.:...:::..:....|...:..|||:..|.|:|:.|::||:|..:|...:|.|.:.|||:|
Zfish   187 RGYIIVDFHEMEEKLEHPHTDEQLQWTVFLISFWGDQIGQKVKKICDCFHTQTFPYPENQAEREE 251

  Fly   261 MIKDVNVRLEDLKLVLSQSADHRSRVLNSASKHLPRWSIMVRKMKAIYHILNFFNPDVTGKCLIG 325
            .:..:..|:||:|.|:.::..:..::|..|...||.|.:.|:|.||:..:||..:|.||.||||.
Zfish   252 TLNGLRGRIEDIKSVMGETEQYMQQLLVRALARLPEWVVQVQKCKAVQTVLNLCSPSVTDKCLIA 316

  Fly   326 EGWVPTNDISTVQDALARASKISESSIPAFMNVIETNEMPPTYTRTNKFTNGFQNLVDSYGMASY 390
            |.|.|.:.:..:|.||....:.|.|::.:|.|.:.....|||...||.||.|||::||:||:|||
Zfish   317 EAWCPVSQLPALQSALREGGRKSGSNVDSFYNRLPATTSPPTLFPTNSFTAGFQSIVDAYGVASY 381

  Fly   391 REVNPALYACITFPFLFAVMFGDLGHGLILLLFASWLIIKEK--QLSSIKEEIFNIFFGGRYIIF 453
            ||||||:|..|||||||||||||:||||::.|.|.|:|::|.  :|.....||:.:.|||||:|.
Zfish   382 REVNPAVYTIITFPFLFAVMFGDVGHGLLMTLAALWMILEENDPKLRKNTNEIWRMMFGGRYLIL 446

  Fly   454 LMGIFSIYTGFIYNDVFSKSMNIFGSAWHM-------NYTRDVVEDENLKYITLRPNDTVYKT-- 509
            |||:||||||.|||:.|||.::.|.|.||:       |:|.:..: :|: |::|.||.|...|
Zfish   447 LMGLFSIYTGAIYNECFSKGLSTFSSGWHVRPNAEFYNWTEETFK-KNM-YLSLDPNVTGVFTGP 509

  Fly   510 YPFGMDPIWQLADNKIIFLNTFKMKLSIIVGVIHMIFGVSMSVVNFAYYKKYASIFLEFLPQVLF 574
            ||||:||||.||:|.:.|||::|||:|:|:|||||.|||.:|..|:.::::.:|:||..:|::.|
Zfish   510 YPFGIDPIWGLANNHLTFLNSYKMKMSVIIGVIHMTFGVCLSFFNYIHFREVSSVFLVLIPELCF 574

  Fly   575 LLLLFGYMVFMMFFKWVVYNDTVEGPLSPACAPSILILFINMILQGSQDTPEPCKEFMFDGQKSI 639
            :|.||||::||:.:||:||     ||::...||||||.||:|.|.......:|    ::.||.::
Zfish   575 MLCLFGYLIFMVIYKWLVY-----GPVNSDSAPSILIHFIDMFLFTENKDNKP----LYTGQMTV 630

  Fly   640 QQVFVVVAIICIPWMLLGKPL--YIMIKRK-TNGAPPPKP----------------QSGGGEGHG 685
            |:|.|:||::.:|.:|||||:  |:..||| .|.....:|                ..|||.|..
Zfish   631 QKVLVIVAVLSVPVLLLGKPIQEYLSHKRKRRNPTGDRRPLLAENGSINSQQGDVDARGGGGGEE 695

  Fly   686 EDDEMGEIFIHQAIHTIEYVLSTVSHTASYLRLWALSLAHAQLSEVLWNMVFSMGFKYDSYIGGI 750
            |:.:...:|:|||||||||.|..:|:||||||||||||||||||||||.||....|...||:|.:
Zfish   696 EEFDTANVFMHQAIHTIEYCLGCISNTASYLRLWALSLAHAQLSEVLWTMVMRQSFGQLSYVGSV 760

  Fly   751 LIYVFFGAWALLTVGILVLIEGLSAFLHTLRLHWVEFMSKFYEGAGYAFEPFAF 804
            :..:.|..:|:|||.||:::||||||||.||||||||.:|||.|.||...||.|
Zfish   761 MAALVFVGFAVLTVSILLVMEGLSAFLHALRLHWVEFQNKFYSGTGYKLTPFDF 814

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-5	NP_001260388.1	NtpI	5..805	CDD:224188	366/830 (44%)
Vha100-5	NP_001260388.1	V_ATPase_I	28..804	CDD:279793	354/805 (44%)
tcirg1b	NP_998234.1	NtpI	27..812	CDD:224188	352/804 (44%)
tcirg1b	NP_998234.1	V_ATPase_I	28..814	CDD:279793	354/805 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53812
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	O	PTHR11629
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X226
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.930