DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vha100-5 and Atp6v0a4

DIOPT Version :9

Sequence 1:	NP_001260388.1	Gene:	Vha100-5 / 34587	FlyBaseID:	FBgn0032373	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	XP_006236358.1	Gene:	Atp6v0a4 / 296981	RGDID:	1305055	Length:	829	Species:	Rattus norvegicus

Alignment Length:	856	Identity:	413/856 - (48%)
Similarity:	570/856 - (66%)	Gaps:	69/856 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGDMFRSEKMALCQLFIQPEAAYASIAELGEKGCVQFRDLNEEVSAFQRKYVNEVRRCDDMERRL 65
            |..:||||:|.|.|:|:|.||||..:|||||.|.|||:|||..|::||||:|||||||:.:||.|
  Rat     1 MASVFRSEEMCLSQVFLQVEAAYCCVAELGELGLVQFKDLNANVNSFQRKFVNEVRRCESLERIL 65

  Fly    66 RYVESEMKKDEVKLPVLRPEEEPIAPNPREIVDLEAQLEKTDNELREMSANGASLDANFRHMQEL 130
            |::|.|| ::|:.:.|  |:::|..|.|||::.||..|||.:.||:|.:.:..:|..:|..:.||
  Rat    66 RFLEDEM-QNEIIIQV--PDKDPGTPLPREMITLETTLEKLEGELQEANQSHQALKKSFLELTEL 127

  Fly   131 KYVLENTEGFFSDQEVINLDVNRKLDPEDPANL------PGAAQRGQLAFVAGVIKLERFFSFER 189
            ||:|:.|:.||..:..:..|    ...||.:.|      | |...|:|.|.||||..||..||||
  Rat   128 KYLLKKTQDFFETETNLGED----FFVEDTSGLLELRAMP-AFMTGKLGFTAGVINRERMASFER 187

  Fly   190 MLWRISRGNIFLRRADIDGLVADEETGRPVLKTVFVAFFQGEQLKQRIKKVCTGYHAAVYPCPSS 254
            :|||:.|||::|:.:::|.|:.|..|...:.|.:|:.|:|||||:.:|||:|.|:.|.:||||..
  Rat   188 LLWRVCRGNVYLKFSEMDTLLEDPVTKEEIKKNIFIIFYQGEQLRLKIKKICDGFRATIYPCPEH 252

  Fly   255 HAERKEMIKDVNVRLEDLKLVLSQSADHRSRVLNSASKHLPRWSIMVRKMKAIYHILNFFNPDVT 319
            .|||:||:..||||||||..|::|:..||.|:|..|:.:...|.|.|:||||:||:||..|.|||
  Rat   253 AAERREMLASVNVRLEDLITVITQTESHRQRLLQEAASNWHSWVIKVQKMKAVYHVLNMCNIDVT 317

  Fly   320 GKCLIGEGWVPTNDISTVQDALARASKISESSIPAFMNVIETNEMPPTYTRTNKFTNGFQNLVDS 384
            .:|:|.|.|.|..|...::.||.:..::|.||:...|..:||...|||:.||||||.||||:||:
  Rat   318 QQCIIAEIWFPVADTRHIKKALEQGMELSGSSMVPIMTEVETKTDPPTFNRTNKFTAGFQNIVDA 382

  Fly   385 YGMASYREVNPALYACITFPFLFAVMFGDLGHGLILLLFASWLIIKEKQLSSIK--EEIFNIFFG 447
            ||:.||||:|||.|..|||||||||||||.|||:::|:.|.|:::.|:.|.:.|  .|::||||.
  Rat   383 YGVGSYREINPAPYTIITFPFLFAVMFGDCGHGMVMLMAALWMVLNERHLLAQKSTNEMWNIFFN 447

  Fly   448 GRYIIFLMGIFSIYTGFIYNDVFSKSMNIFGSAWHM-------NYTRDVVEDENLKYITLRPN-D 504
            |||:|.||||||||||.||||.||||.|||||:|.:       .:...|||..  .|:.|.|. .
  Rat   448 GRYLILLMGIFSIYTGLIYNDCFSKSFNIFGSSWSVQPMFRNGTWNAHVVEQN--PYLQLDPAIP 510

  Fly   505 TVY--KTYPFGMDPIWQLADNKIIFLNTFKMKLSIIVGVIHMIFGVSMSVVNFAYYKKYASIFLE 567
            .||  ..||||:||||.||.||:.|||::|||:|:|:|::||||||.:|:.|..|:::..:|.|:
  Rat   511 GVYSGNPYPFGIDPIWNLASNKLTFLNSYKMKMSVILGIVHMIFGVILSLFNHIYFRRTLNIILQ 575

  Fly   568 FLPQVLFLLLLFGYMVFMMFFKWVVYNDTVEGPLSPACAPSILILFINMIL---QGSQDTPEPCK 629
            |:|:::|:|.||||:|||:.|||..|:......     ||||||.||.|.|   ..|.:.|
  Rat   576 FIPEMIFMLSLFGYLVFMIIFKWCQYDAHTSQK-----APSILIHFIGMFLFDYDDSSNAP---- 631

  Fly   630 EFMFDGQKSIQQVFVVVAIICIPWMLLGKPLYIMIK---------------------RKTNGAPP 673
              ::..|:.:|..||::|::.:|||||.||..:..|                     :||.||
  Rat   632 --LYGHQQEVQTFFVIIALVSVPWMLLIKPFILRAKHQKSQLQSFTIHEDAMEGPSVKKTAGA-- 692

  Fly   674 PKPQSGGGEGHGEDDEMGEIFIHQAIHTIEYVLSTVSHTASYLRLWALSLAHAQLSEVLWNMVFS 738
                .|..|||.|:...|:||:|||||||||.|..:|:|||||||||||||||:||||||.||.|
  Rat   693 ----HGTKEGHEEEFNFGDIFVHQAIHTIEYCLGCISNTASYLRLWALSLAHAELSEVLWTMVMS 753

  Fly   739 MGFKYDSYIGGILIYVFFGAWALLTVGILVLIEGLSAFLHTLRLHWVEFMSKFYEGAGYAFEPFA 803
            :|.:...:.|.:.:::.|..:|:|||.||:::||||||||.||||||||.:|||||||:.|.||:
  Rat   754 IGLRLRGWGGLVGVFIIFAVFAVLTVAILLVMEGLSAFLHALRLHWVEFQNKFYEGAGFKFSPFS 818

  Fly   804 FKTILDVSEDD 814
            ||.:|:.:.::
  Rat   819 FKHVLEGAAEE 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-5	NP_001260388.1	NtpI	5..805	CDD:224188	409/841 (49%)
Vha100-5	NP_001260388.1	V_ATPase_I	28..804	CDD:279793	395/817 (48%)
Atp6v0a4	XP_006236358.1	NtpI	28..820	CDD:224188	395/818 (48%)
Atp6v0a4	XP_006236358.1	V_ATPase_I	28..819	CDD:279793	395/817 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1269
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53812
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	O	PTHR11629
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X226
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.830