DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vha100-5 and vph1

DIOPT Version :9

Sequence 1:	NP_001260388.1	Gene:	Vha100-5 / 34587	FlyBaseID:	FBgn0032373	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_594219.2	Gene:	vph1 / 2542310	PomBaseID:	SPAC16E8.07c	Length:	831	Species:	Schizosaccharomyces pombe

Alignment Length:	855	Identity:	339/855 - (39%)
Similarity:	489/855 - (57%)	Gaps:	85/855 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 MFRSEKMALCQLFIQPEAAYASIAELGEKGCVQFRDLNEEVSAFQRKYVNEVRRCDDMERRLRYV 68
            :||||:::|.||::..|:|...::.|||...:.|:|||.:|.||||.:|.|:||..|.||.|||:
pombe     5 LFRSEEVSLVQLYLPTESARPIMSALGELSTIHFKDLNPDVVAFQRSFVREIRRLTDTERLLRYL 69

  Fly    69 ESEMKKDEVKLP--VLRPEEEPIAPNPREIVDLEAQLEKTDNELREMSANGASLDANFRHMQELK 131
            .||:..:.:.:|  .|.|..|.:..: ..|.|:..::.:.:..:|::..:...|:|  |::|:|:
pombe    70 HSEIDLNGIHVPDHNLPPSYESVLES-STIEDIIERITRLEARVRQLVESSQLLEA--RYLQQLE 131

  Fly   132 Y--VLENTEGFFS------DQEVINLDVNRKLDPEDPANLP---GAAQRG--------------- 170
            :  ||...:.|||      |....|.:.:.....||....|   .|.:.|
pombe   132 FANVLTKADAFFSKSGNTVDPLRNNYETSSIFSGEDDTTAPLIENALELGTTGTFDSEETSPQMN 196

  Fly   171 -QLAFVAGVIKLERFFSFERMLWRISRGNIFLR--RAD---IDGLVADEETGRPVLKTVFVAFFQ 229
             .|.||:|:|...:|...||:|||..|||:|:.  |||   |.|...:||      ||:|:....
pombe   197 TTLDFVSGIIPTVKFQFLERILWRTLRGNLFIHQVRADDSLIHGAEKNEE------KTIFLVIAH 255

  Fly   230 GEQLKQRIKKVCTGYHAAVYPCPSSHAERKEMIKDVNVRLEDLKLVLSQSADHRSRVLNSASKHL 294
            |.|:..||:|:.....|.::|.......|...|:..||.:.||..||..:.......|...::|:
pombe   256 GTQILLRIRKISESLGATLFPVEEDAPGRTSQIQQANVSISDLNAVLENTRSALYTELTFIAEHI 320

  Fly   295 PRWSIMVRKMKAIYHILNFFNPDVTGKCLIGEGWVPTNDISTVQDALARASKISESSIPAFMNVI 359
            ..|..::.|.|.::.::|.||.|...||||.|||.||.::..||..|...|.:::|..|..:||:
pombe   321 SAWEAVLHKDKTVFQVMNLFNYDQNHKCLIAEGWCPTANLPMVQKTLRNISDLTDSQAPTILNVV 385

  Fly   360 ETNEMPPTYTRTNKFTNGFQNLVDSYGMASYREVNPALYACITFPFLFAVMFGDLGHGLILLLFA 424
            .|:|.||||.|.||||.|||:::||||:|:|||||..:.|.:|||||||:||||||||.|:...|
pombe   386 HTSEQPPTYFRVNKFTEGFQSIIDSYGIATYREVNHGIVAIVTFPFLFAIMFGDLGHGAIMASVA 450

  Fly   425 SWLIIKEKQLSSIK--EEIFNIFFGGRYIIFLMGIFSIYTGFIYNDVFSKSMNIFGSAWHMNYTR 487
            ...::.||.|.:.|  :||..:.|.||||:.|||:||:|.||:|||:|||.|:||.|.|    ..
pombe   451 LMFVLYEKTLGAKKDLDEIVGMVFYGRYIVLLMGLFSMYVGFVYNDLFSKPMSIFSSRW----VW 511

  Fly   488 DVVEDENLKYITLRPNDTVYKTYPFGMDPIWQLADNKIIFLNTFKMKLSIIVGVIHMIFGVSMSV 552
            .|..:|.:      .......|||.|:||.|..|||.::|:|::|||||||:|||||.|.:.:|:
pombe   512 PVKSEEAI------ARAVQVGTYPIGIDPTWHSADNNLLFMNSYKMKLSIILGVIHMTFCLFLSL 570

  Fly   553 VNFAYYKKYASIFLEFLPQVLFLLLLFGYMVFMMFFKWVVYNDTVEGPLSPACAPSILILFINMI 617
            .|:.::|:...|:..|:|.::||..:|||:|..:.:||.:  |.....|.|   ||:|.:.|.|.
pombe   571 SNYRFFKRKLDIYAVFVPSLIFLEAIFGYLVITIVYKWCI--DWKAKDLQP---PSLLNMLILMF 630

  Fly   618 LQGSQDTPEPCKEFMFDGQKSIQQVFVVVAIICIPWMLLGKPLYIMIKRKTNGAPPPKPQS---- 678
            |     :|...::.::.|||.:|...|:.|:||:||:|:.|| :::.:|.:|  ...|.||
pombe   631 L-----SPGTLEDQLYPGQKYLQVGLVIAALICVPWLLIVKP-FVLWRRHSN--EENKYQSLNSD 687

  Fly   679 -------------GGGEGHGEDDEMGEIFIHQAIHTIEYVLSTVSHTASYLRLWALSLAHAQLSE 730
                         ...|...|..|:||:.|||.|||||:.|..|||||||||||||||||.|||.
pombe   688 LPNVDEADALMAVDSQEKQAEPFELGEVVIHQVIHTIEFCLGCVSHTASYLRLWALSLAHNQLSS 752

  Fly   731 VLWNMVFSMGFKYDSYIGGILIYVFFGAWALLTVGILVLIEGLSAFLHTLRLHWVEFMSKFYEGA 795
            |||||..:.||:....:|.|.:.:.||.|.:.|..:||.:||.||.||:|||||||.|||.:||.
pombe   753 VLWNMTLANGFRMTGIVGSIFVVILFGFWFIATCVVLVAMEGTSAMLHSLRLHWVEGMSKHFEGE 817

  Fly   796 GYAFEPFAFK 805
            ||||.||.||
pombe   818 GYAFTPFTFK 827

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-5	NP_001260388.1	NtpI	5..805	CDD:224188	337/852 (40%)
Vha100-5	NP_001260388.1	V_ATPase_I	28..804	CDD:279793	328/828 (40%)
vph1	NP_594219.2	NtpI	27..828	CDD:224188	330/833 (40%)
vph1	NP_594219.2	V_ATPase_I	29..826	CDD:279793	328/828 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	572	1.000	Domainoid score	I34
eggNOG	1	0.900	-	-		E1_COG1269
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	599	1.000	Inparanoid score	I160
OMA	1	1.010	-	-		QHG53812
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	1	1.000	-	-		otm47222
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	O	PTHR11629
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X226
TreeFam	1	0.960	-	-
	12	11.830