DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vha100-5 and Vha100-3

DIOPT Version :9

Sequence 1:	NP_001260388.1	Gene:	Vha100-5 / 34587	FlyBaseID:	FBgn0032373	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_725837.1	Gene:	Vha100-3 / 246543	FlyBaseID:	FBgn0028669	Length:	904	Species:	Drosophila melanogaster

Alignment Length:	917	Identity:	325/917 - (35%)
Similarity:	495/917 - (53%)	Gaps:	147/917 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 FRSEKMALCQLFIQPEAAYASIAELGEKGCVQFRDLNEEVSAFQRKYVNEVRRCDDMERRLRYVE 69
            ||||.|.||||.:..|.|:..:.|:|..|.|||.::.:|.......|..:|.:|.::   ||.|:
  Fly    15 FRSEDMDLCQLLLHTENAFDCLIEVGHHGAVQFNNVYDEDRLLNNLYSKKVTQCYEL---LRIVD 76

  Fly    70 S------EMKKDEVKLPVLRPEEEPIAPNPREIVDLEAQLEKTD-----NELREMSANGAS---- 119
            |      ::..:|:..|               .||.|.:|::.|     :.|:.:....::
  Fly    77 SLHTYIVQLHVNEIFYP---------------DVDRENRLKEKDLAKYSDSLKRIHVEASAVTEH 126

  Fly   120 ---LDANFRHMQELKYVLE----------NTEGFFSDQEVINLDVNRKLDPEDPANLPGAAQRGQ 171
               ||:....|.|..:.|.          .:|..:|:..||.|       .:|.....| |....
  Fly   127 YYRLDSRRNRMMEHSFALNKANKYMVSDMGSELLYSESTVIGL-------VQDATTTSG-AYPAH 183

  Fly   172 LAFVAGVIKLERFFSFERMLWRISRGNIFLRRADIDGLVADEETG-RP--VLKTVFVAFFQGEQL 233
            |.::.|.|:.::|:|||.:|:|:...|:.:|.:::...|.:...| :|  |.|...:.......:
  Fly   184 LNYMIGCIRADKFYSFELLLYRLCSFNLIIRFSEMPSPVYEYHYGYKPERVRKFAILMMASSTMI 248

  Fly   234 KQRIKKVCTGYHAAVYPCPSSHAERKEMIKDVNVRLEDLKLVLSQSADHRSRVLNSASKHLPRWS 298
            ..::.|:|..||..:|.||||.::|::.:|:::..:.:::.||.::...|.::|..|.:.|....
  Fly   249 WPKVLKICAHYHVNIYDCPSSASQREDKVKELSQEIVNVEKVLKEAELMRRQILEVAGRDLFIIR 313

  Fly   299 IMVRKMKAIYHILNFFNPDVTG-----KCLIGEGWVPTNDISTVQDALARASKIS------ESSI 352
            :.:||...:|.::|...  :.|     :.|:.|.::|::|:..|:..|..||:||      :||.
  Fly   314 VNLRKALKVYDLMNRLR--LVGGVEVPRYLLAEVYIPSSDVPEVEVILRNASRISGGADNIDSSD 376

  Fly   353 PAFMNVIET--------------------------------NEMPPTYTRTNKFTNGFQNLVDSY 385
            ...||.::|                                |.|||||.|.||||.|||||:|:|
  Fly   377 EDEMNDMKTMPNTTPYPIEADFQPLEDMSAGAILLKKNRLVNHMPPTYFRLNKFTRGFQNLIDAY 441

  Fly   386 GMASYREVNPALYACITFPFLFAVMFGDLGHGLILLLFASWLIIKEKQL------SSIKEEIFNI 444
            |||.|:|:|||.|..|||||||||||||||||::|:||:|.:|.|.:::      ::.:.||.||
  Fly   442 GMADYKELNPAPYTIITFPFLFAVMFGDLGHGILLILFSSLMIWKHREIEKYQINATSENEILNI 506

  Fly   445 FFGGRYIIFLMGIFSIYTGFIYNDVFSKSMNIFGSAWHMNYTRDVVEDENLKYITL---RPNDTV 506
            .:.|||||.|||:||:|.|.:||.|.:|..|:|||:|...|....|.|... ::||   .|:...
  Fly   507 LYAGRYIILLMGVFSVYMGLVYNIVMAKGFNLFGSSWSCRYNETTVYDPAF-HVTLDSSHPHFYS 570

  Fly   507 YKTYPFGMDPIWQL-ADNKIIFLNTFKMKLSIIVGVIHMIFGVSMSVVNFAYYKKYASIFLEFLP 570
            ...||.||||:|.: ..:.|...|:.|||::|::|:..|:||:.::..|.....:.|.:.|..:|
  Fly   571 GHPYPLGMDPVWAVCGQDSITTTNSLKMKMAIVLGISQMMFGLGLAAANCVLMNRKADLILVVIP 635

  Fly   571 QVLFLLLLFGYMVFMMFFKWVVYNDTVEGPLSPACAPSILILFINMILQGSQDTPEPCKEFMFDG 635
            |::|:|.||||:||::|:||:.|......|.:.|||||:||.||||:|...:|..|.|.::|:..
  Fly   636 QMIFMLCLFGYLVFLIFYKWMSYGGHKPAPYNAACAPSVLITFINMMLMKKEDPVENCLDYMYPN 700

  Fly   636 QKSIQQVFVVVAIICIPWMLLGKPLYIMIKRK-----------------------------TNGA 671
            ::.|:...|.:|...||.:|.|||:|:|.:|:                             .:.:
  Fly   701 ERMIEFALVGIAFCTIPILLAGKPIYLMRRRRKMQQERERDFKRMRRQTIAEMRSTMRYTDDDNS 765

  Fly   672 PPPKPQSGGGEGHGEDDEMGEIFIHQAIHTIEYVLSTVSHTASYLRLWALSLAHAQLSEVLWNMV 736
            ...:.:|...|   |:.||.||:||..|||||.||.:|||||||||||||||||.|||:|||:||
  Fly   766 ETSRQKSVDNE---EEHEMSEIWIHSGIHTIETVLGSVSHTASYLRLWALSLAHDQLSDVLWHMV 827

  Fly   737 FSMGF--KYDSYIGGILIYVFFGAWALLTVGILVLIEGLSAFLHTLRLHWVEFMSKFYEGAGYAF 799
            .:.||  ....|.|..::...|.|||:|||.|||::|||||||||||||||||.|||:.|||.:|
  Fly   828 LTKGFANTLPLYYGVPVLMATFFAWAILTVAILVMMEGLSAFLHTLRLHWVEFQSKFFGGAGESF 892

  Fly   800 EPFAFKT 806
            :.|.|.|
  Fly   893 KAFNFPT 899

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-5	NP_001260388.1	NtpI	5..805	CDD:224188	323/914 (35%)
Vha100-5	NP_001260388.1	V_ATPase_I	28..804	CDD:279793	312/890 (35%)
Vha100-3	NP_725837.1	V_ATPase_I	38..897	CDD:279793	312/890 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451295
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1269
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S598
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	P	PTHR11629
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.700