DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vha100-5 and ATP6V0A2

DIOPT Version :9

Sequence 1:	NP_001260388.1	Gene:	Vha100-5 / 34587	FlyBaseID:	FBgn0032373	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_036595.2	Gene:	ATP6V0A2 / 23545	HGNCID:	18481	Length:	856	Species:	Homo sapiens

Alignment Length:	872	Identity:	373/872 - (42%)
Similarity:	546/872 - (62%)	Gaps:	78/872 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGDMFRSEKMALCQLFIQPEAAYASIAELGEKGCVQFRDLNEEVSAFQRKYVNEVRRCDDMERRL 65
            ||.:||||.|.|.|||:|...||..::.|||||.|||||||:.||:||||:|.||:||:::||.|
Human     1 MGSLFRSETMCLAQLFLQSGTAYECLSALGEKGLVQFRDLNQNVSSFQRKFVGEVKRCEELERIL 65

  Fly    66 RYVESEMKKDEVKLPVLRPEEEPIAPNPREIVDLEAQLEKTDNELREMSANGASLDANFRHMQEL 130
            .|:..|:.:.::.||  ..|..|.||..:::::::.||:|.:.||||::.|...|..|...:.|.
Human    66 VYLVQEINRADIPLP--EGEASPPAPPLKQVLEMQEQLQKLEVELREVTKNKEKLRKNLLELIEY 128

  Fly   131 KYVLENTEGFF--------SDQEVINLDVNRKLDPEDPANLPGAAQRGQLAFVAGVIKLERFFSF 187
            .::|..|:.|.        :.:|..:|:.:..||......| ||    :|.||:|:|...:..:|
Human   129 THMLRVTKTFVKRNVEFEPTYEEFPSLESDSLLDYSCMQRL-GA----KLGFVSGLINQGKVEAF 188

  Fly   188 ERMLWRISRGNIFLRRADIDGLVADEETGRPVLKTVFVAFFQGEQLKQRIKKVCTGYHAAVYPCP 252
            |:||||:.:|...:..|::|..:.|.|||..:...||:..|.|||:..::||:|..||..|||.|
Human   189 EKMLWRVCKGYTIVSYAELDESLEDPETGEVIKWYVFLISFWGEQIGHKVKKICDCYHCHVYPYP 253

  Fly   253 SSHAERKEMIKDVNVRLEDLKLVLSQSADHRSRVLNSASKHLPRWSIMVRKMKAIYHILNFFNPD 317
            ::..||:|:.:.:|.|::||..||.::.|:..:||..|::.:....|.|:|||||||:||..:.|
Human   254 NTAEERREIQEGLNTRIQDLYTVLHKTEDYLRQVLCKAAESVYSRVIQVKKMKAIYHMLNMCSFD 318

  Fly   318 VTGKCLIGEGWVPTNDISTVQDALARASKISESSIPAFMNVIETNEMPPTYTRTNKFTNGFQNLV 382
            ||.||||.|.|.|..|:..::.||...|:.|.::||:|||:|.|.|.|||..||||||.||||:|
Human   319 VTNKCLIAEVWCPEADLQDLRRALEEGSRESGATIPSFMNIIPTKETPPTRIRTNKFTEGFQNIV 383

  Fly   383 DSYGMASYREVNPALYACITFPFLFAVMFGDLGHGLILLLFASWLIIKEK--QLSSIKEEIFNIF 445
            |:||:.|||||||||:..|||||||||||||.|||.::.|||..|::.|.  :|:. .:||..:|
Human   384 DAYGVGSYREVNPALFTIITFPFLFAVMFGDFGHGFVMFLFALLLVLNENHPRLNQ-SQEIMRMF 447

  Fly   446 FGGRYIIFLMGIFSIYTGFIYNDVFSKSMNIFGSAWHMN--YTRDVVEDENLKYITLRPNDTVYK 508
            |.||||:.|||:||:|||.||||.||||:|:|||.|:::  |:......|:.|.:..  ||:|.:
Human   448 FNGRYILLLMGLFSVYTGLIYNDCFSKSVNLFGSGWNVSAMYSSSHPPAEHKKMVLW--NDSVVR 510

  Fly   509 -----------------TYPFGMDPIWQLADNKIIFLNTFKMKLSIIVGVIHMIFGVSMSVVNFA 556
                             .||.|:||||.||.|::.|||:||||:|:|:|:|||.|||.:.:.|..
Human   511 HNSILQLDPSIPGVFRGPYPLGIDPIWNLATNRLTFLNSFKMKMSVILGIIHMTFGVILGIFNHL 575

  Fly   557 YYKKYASIFLEFLPQVLFLLLLFGYMVFMMFFKWVVYNDTVEGPLSPACAPSILILFINMILQGS 621
            :::|..:|:|..:|::||:|.:|||::||:|:||:|::..     :...||||||.||||.|..:
Human   576 HFRKKFNIYLVSIPELLFMLCIFGYLIFMIFYKWLVFSAE-----TSRVAPSILIEFINMFLFPA 635

  Fly   622 QDTPEPCKEFMFDGQKSIQQVFVVVAIICIPWMLLGKPL------------------YIMIKRKT 668
            ..|     ..::.||:.:|:|.:||..:.:|.:.|||||                  |.:|::.:
Human   636 SKT-----SGLYTGQEYVQRVLLVVTALSVPVLFLGKPLFLLWLHNGRSCFGVNRSGYTLIRKDS 695

  Fly   669 N------GAPP-----PKPQSGGGEGHGEDDEMGEIFIHQAIHTIEYVLSTVSHTASYLRLWALS 722
            .      |:..     .:.:.|..|...|:...|||.:.|.||:|||.|..:|:|||||||||||
Human   696 EEEVSLLGSQDIEEGNHQVEDGCREMACEEFNFGEILMTQVIHSIEYCLGCISNTASYLRLWALS 760

  Fly   723 LAHAQLSEVLWNMVFSMGFKYDSYIGGILIYVFFGAWALLTVGILVLIEGLSAFLHTLRLHWVEF 787
            |||||||:|||.|:..:|.:.|:..|.:|:......:|:||:.||:::||||||||.:|||||||
Human   761 LAHAQLSDVLWAMLMRVGLRVDTTYGVLLLLPVIALFAVLTIFILLIMEGLSAFLHAIRLHWVEF 825

  Fly   788 MSKFYEGAGYAFEPFAFKTILDVSEDD 814
            .:|||.|||..|.||:|..:.....:|
Human   826 QNKFYVGAGTKFVPFSFSLLSSKFNND 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vha100-5	NP_001260388.1	NtpI	5..805	CDD:224188	369/857 (43%)
Vha100-5	NP_001260388.1	V_ATPase_I	28..804	CDD:279793	357/833 (43%)
ATP6V0A2	NP_036595.2	V_ATPase_I	27..842	CDD:307581	357/834 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1269
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53812
OrthoDB	1	1.010	-	-		D164762at33208
OrthoFinder	1	1.000	-	-		FOG0000328
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100301
Panther	1	1.100	-	-	O	PTHR11629
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X226
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.830